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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 18, 2014, Pages 4490-4495

Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease

(12) Neudorfer, Catharina a,b Shanab, Karem a,b Jurik, Andreas b Schreiber, Veronika b Neudorfer, Carolina b Vraka, Chrysoula a,b Schirmer, Eva b Holzer, Wolfgang b Ecker, Gerhard b Mitterhauser, Markus a Wadsak, Wolfgang a Spreitzer, Helmut b

a MEDICAL UNIVERSITY OF VIENNA (Austria)

b UNIVERSITY OF VIENNA (Austria)

Author keywords

Alzheimer's disease; MAO B; Molecular imaging; PET; Pyrazoline derivatives

Indexed keywords

5 (ANTHRACEN 9 YL) 3 PHENYL 4,5 DIHYDRO 1H PYRAZOLE DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; BIOLOGICAL MARKER; MONOAMINE OXIDASE B INHIBITOR; PYRAZOLINE DERIVATIVE; TRACER; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); MONOAMINE OXIDASE INHIBITOR; PYRAZOLE DERIVATIVE;

ALDOL REACTION; ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; CATALYST; CRYSTAL STRUCTURE; CYCLIZATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; ISOTOPE LABELING; LIPOPHILICITY; MOLECULAR DOCKING; MOLECULAR IMAGING; POSITRON EMISSION TOMOGRAPHY; TRANSESTERIFICATION; CHEMICAL STRUCTURE; CHEMISTRY; DIAGNOSTIC USE; DOSE RESPONSE; EARLY DIAGNOSIS; ENZYMOLOGY; HUMAN; METABOLISM; STANDARD; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; EARLY DIAGNOSIS; HUMANS; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; REFERENCE STANDARDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906964183 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.07.085 Document Type: Article

Times cited : (11)

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