Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis

Circulation

Volumn 131, Issue 13, 2015, Pages 1160-1170

  Zhang, Si ^a   Zhang, Shenghui ^a   Hu, Liang ^a   Zhai, Lili ^a   Xue, Ruyi ^b   Ye, Jianqin ^a   Chen, Leilei ^a   Cheng, Guanjun ^c   Mruk, Jozef ^d   Kunapuli, Satya P ^e   Ding, Zhongren ^a  

^a FUDAN UNIVERSITY   (China)

^b ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF KANSAS SCHOOL OF MEDICINE WICHITA   (United States)

^e TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood platelets; Mitogen activated protein kinases; Nucleotide binding oligomerization domain 2; Receptor interacting protein serine threonine kinase 2; Thrombosis

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; COLLAGEN; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYTOKINE; FERROUS CHLORIDE; GUANYLATE CYCLASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MURAMYL DIPEPTIDE; NITRIC OXIDE; PATTERN RECOGNITION RECEPTOR; THROMBIN; CARD15 PROTEIN, MOUSE; IL1B PROTEIN, MOUSE; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; NOD2 PROTEIN, HUMAN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE 2; RIPK2 PROTEIN, HUMAN; RIPK2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY THROMBOSIS; ARTICLE; BACTERIAL INFECTION; BLOOD CLOT RETRACTION; BLOOD CLOTTING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; MESENTERIC ARTERY; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); SEPSIS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE TRANSFUSION; WESTERN BLOTTING; AGONISTS; ANIMAL; BACTEREMIA; BIOSYNTHESIS; BLOOD; DRUG EFFECTS; HEMOSTASIS; INFLAMMATION; METABOLISM; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOSIS;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ANIMALS; BACTEREMIA; BLOOD PLATELETS; CLOT RETRACTION; CYCLIC GMP; DIMERIZATION; HEMOSTASIS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED NOD; NITRIC OXIDE; NOD2 SIGNALING ADAPTOR PROTEIN; PLATELET ACTIVATION; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASE 2; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; THROMBOSIS;

EID: 84929298352     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.013743     Document Type: Article

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