Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice

Journal of Experimental Medicine

Volumn 193, Issue 4, 2001, Pages 459-469

  Nieswandt, Bernhard ^a   Schulte, Valerie ^a   Bergmeier, Wolfgang ^a   Mokhtari Nejad, Rabée ^a   Rackebrandt, Kirsten ^a   Cazenave, Jean Pierre ^b   Ohlmann, Philippe ^b   Gachet, Christian ^b   Zirngibl, Hubert ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b INSERM   (France)

Author keywords

Collagen; Immunotherapy; Mouse; Receptor; Thrombosis

Indexed keywords

ADENOSINE DIPHOSPHATE; ADRENALIN; COLLAGEN; COLLAGEN RECEPTOR; GLYCOPROTEIN; GLYCOPROTEIN VI; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY JAQ1; PHORBOL MYRISTATE; THROMBOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING TIME; CONTROLLED STUDY; IMMUNOTHERAPY; ISCHEMIC HEART DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN DEPLETION; THROMBOCYTE ACTIVATION; THROMBOEMBOLISM; THROMBOSIS; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES, MONOCLONAL; BLEEDING TIME; BLOOD PLATELETS; C-REACTIVE PROTEIN; COLLAGEN; FIBRINOGEN; INTEGRINS; MICE; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, COLLAGEN; THROMBOSIS;

EID: 0035910757     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.4.459     Document Type: Article

References (55)

1. Platelet physiology and abnormalities of platelet function
2. Platelet physiology and abnormalities of platelet function
3. The pathogenesis of coronary artery disease and the acute coronary syndromes
4. The pathogenesis of coronary artery disease and the acute coronary syndromes
5. Acute myocardial ischemia: Role of atherosclerosis, thrombosis, platelet activation, coronary vasospasm, and altered arachidonic acid metabolism
6. Platelet interaction with collagen fibrils in flowing blood. I. Reaction of human platelets with alpha chymotrypsin-digested subendothelium
7. Macromolecules that link platelets following vessel wall injury
8. Plateletreactive sites in collagens type I and type III. Evidence for separate adhesion and aggregatory sites
9. Distinct determinants on collagen support alpha 2 beta 1 integrin-mediated platelet adhesion and platelet activation
10. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow
11. The alpha 2 beta 1 integrin: A collagen receptor on platelets and other cells
12. A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion
13. Glycoprotein VI is a major collagen receptor for platelet activation: It recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not
14. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain
15. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain
16. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors
17. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: A platelet-specific collagen receptor from the immunoglobulin superfamily
18. A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets
19. The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
20. Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets
21. Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets
22. Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency
23. Structural and functional characterization of the mouse von Willebrand factor receptor GPIbI-X with novel monoclonal antibodies
24. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice
25. Detecting proteins separated by 2-D gel electrophoresis
26. New zwitterionic detergents improve the analysis of membrane proteins by two-dimensional electrophoresis
27. Mouse antithrombotic assay: A simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol
28. Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis
29. Evidence for two distinct epitopes within collagen for activation of murine platelets
30. Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice
31. A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta 1
32. Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor
33. A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1
34. +-dependent binding of collagen by the integrin alpha 2beta 1 in human platelets
35. Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets
36. Atherosclerosis
37. Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia
38. Deficiency of P62, a putative collagen receptor, in platelets from a patient with defective collageninduced platelet aggregation
39. Mechanisms initiating platelet thrombus formation
40. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
41. In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation
42. Characterization of the platelet membrane glycoprotein abnormalities in Bernard-Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis
43. Fc receptor biology
44. Fc receptors
45. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia
46. Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response of single, collagen-adherent platelets
47. Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis"
48. Platelet GPIIb-IIIa blockers
49. Platelet glycoprotein IIb/IIIa antagonists. What are the relevant issues concerning their pharmacology and clinical use?
50. A critical reappraisal of the bleeding time
51. The collagen-platelet interaction
52. Involvement of activated integrin alpha2beta1 in the firm adhesion of platelets onto a surface of immobilized collagen under flow conditions
53. Update on collagen receptor interactions in platelets: Is the two-state model still valid?
54. Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation
55. Convulxin binding to platelet receptor GPVI: Competition with collagen related peptides