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Volumn 6, Issue , 2015, Pages

Absence of surrogate light chain results in spontaneous autoreactive germinal centres expanding VH81X-expressing B cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; SURROGATE IMMUNOGLOBULIN LIGHT CHAIN; ANTIINFECTIVE AGENT; IMMUNOGLOBULIN HEAVY CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84929208541     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8077     Document Type: Article
Times cited : (14)

References (68)
  • 1
    • 56349161598 scopus 로고    scopus 로고
    • B-cell tolerance checkpoints in health and autoimmunity
    • Meffre, E. & Wardemann, H. B-cell tolerance checkpoints in health and autoimmunity. Curr. Opin. Immunol. 20, 632-638 (2008).
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 632-638
    • Meffre, E.1    Wardemann, H.2
  • 3
    • 59649105484 scopus 로고    scopus 로고
    • RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes
    • Panigrahi, A. K. et al. RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes. J. Exp. Med. 205, 2985-2994 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2985-2994
    • Panigrahi, A.K.1
  • 4
    • 0029994333 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Kotzin, B. L. Systemic lupus erythematosus. Cell 85, 303-306 (1996).
    • (1996) Cell , vol.85 , pp. 303-306
    • Kotzin, B.L.1
  • 5
    • 0015872420 scopus 로고
    • The immunopathology of joint inflammation in rheumatoid arthritis
    • Zvaifler, N. J. The immunopathology of joint inflammation in rheumatoid arthritis. Adv. Immunol. 16, 265-336 (1973).
    • (1973) Adv. Immunol. , vol.16 , pp. 265-336
    • Zvaifler, N.J.1
  • 6
    • 0142009533 scopus 로고    scopus 로고
    • Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    • Arbuckle, M. R. et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N. Engl. J. Med. 349, 1526-1533 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1526-1533
    • Arbuckle, M.R.1
  • 7
    • 67650104060 scopus 로고    scopus 로고
    • What happens before the onset of rheumatoid arthritis?
    • Rantapaa-Dahlqvist, S. What happens before the onset of rheumatoid arthritis? Curr. Opin. Rheumatol. 21, 272-278 (2009).
    • (2009) Curr. Opin. Rheumatol. , vol.21 , pp. 272-278
    • Rantapaa-Dahlqvist, S.1
  • 8
    • 20444485767 scopus 로고    scopus 로고
    • Cellular and genetic mechanisms of self tolerance and autoimmunity
    • Goodnow, C. C., Sprent, J., Fazekas de St Groth, B. & Vinuesa, C. G. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 435, 590-597 (2005).
    • (2005) Nature , vol.435 , pp. 590-597
    • Goodnow, C.C.1    Sprent, J.2    Fazekas De-St-Groth, B.3    Vinuesa, C.G.4
  • 9
    • 84883801440 scopus 로고    scopus 로고
    • Diversity among memory B cells: Origin, consequences, and utility
    • Tarlinton, D. & Good-Jacobson, K. Diversity among memory B cells: origin, consequences, and utility. Science 341, 1205-1211 (2013).
    • (2013) Science , vol.341 , pp. 1205-1211
    • Tarlinton, D.1    Good-Jacobson, K.2
  • 10
    • 84897051685 scopus 로고    scopus 로고
    • The imperfect control of self-reactive germinal center B cells
    • Brink, R. The imperfect control of self-reactive germinal center B cells. Curr. Opin. Immunol. 28, 97-101 (2014).
    • (2014) Curr. Opin. Immunol. , vol.28 , pp. 97-101
    • Brink, R.1
  • 11
    • 37849035658 scopus 로고    scopus 로고
    • Sites and stages of autoreactive B cell activation and regulation
    • Shlomchik, M. J. Sites and stages of autoreactive B cell activation and regulation. Immunity 28, 18-28 (2008).
    • (2008) Immunity , vol.28 , pp. 18-28
    • Shlomchik, M.J.1
  • 14
    • 0034798017 scopus 로고    scopus 로고
    • Spontaneous formation of germinal centers in autoimmune mice
    • Luzina, I. G. et al. Spontaneous formation of germinal centers in autoimmune mice. J. Leukoc. Biol. 70, 578-584 (2001).
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 578-584
    • Luzina, I.G.1
  • 15
    • 84873666705 scopus 로고    scopus 로고
    • The role of somatic hypermutation in the generation of pathogenic antibodies in SLE
    • Schroeder, K., Herrmann, M. & Winkler, T. H. The role of somatic hypermutation in the generation of pathogenic antibodies in SLE. Autoimmunity 46, 121-127 (2013).
    • (2013) Autoimmunity , vol.46 , pp. 121-127
    • Schroeder, K.1    Herrmann, M.2    Winkler, T.H.3
  • 16
    • 77949312474 scopus 로고    scopus 로고
    • Plugging the leaky pre-B cell receptor
    • Conley, M. E. & Burrows, P. D. Plugging the leaky pre-B cell receptor. J. Immunol. 184, 1127-1129 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 1127-1129
    • Conley, M.E.1    Burrows, P.D.2
  • 17
    • 21844445331 scopus 로고    scopus 로고
    • The pre-B-cell receptor: Selector of fitting immunoglobulin heavy chains for the B-cell repertoire
    • Melchers, F. The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire. Nat. Rev. Immunol. 5, 578-584 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 578-584
    • Melchers, F.1
  • 18
    • 0033711628 scopus 로고    scopus 로고
    • Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities
    • Xu, J. L. & Davis, M. M. Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities. Immunity 13, 37-45 (2000).
    • (2000) Immunity , vol.13 , pp. 37-45
    • Xu, J.L.1    Davis, M.M.2
  • 19
    • 84879558580 scopus 로고    scopus 로고
    • The link between antibodies to OxLDL and natural protection against pneumococci depends on DH gene conservation
    • Vale, A. M. et al. The link between antibodies to OxLDL and natural protection against pneumococci depends on DH gene conservation. J. Exp. Med. 210, 875-890 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 875-890
    • Vale, A.M.1
  • 20
    • 0026740330 scopus 로고
    • Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas
    • Winkler, T. H., Fehr, H. & Kalden, J. R. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur. J. Immunol. 22, 1719-1728 (1992).
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1719-1728
    • Winkler, T.H.1    Fehr, H.2    Kalden, J.R.3
  • 21
    • 0028292951 scopus 로고
    • Genetic and structural evidence for antigen selection of anti-DNA antibodies
    • Radic, M. Z. & Weigert, M. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu. Rev. Immunol. 12, 487-520 (1994).
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 487-520
    • Radic, M.Z.1    Weigert, M.2
  • 22
    • 0033178269 scopus 로고    scopus 로고
    • Anti-DNA autoantibodies: A puzzle of autoimmune phenomena
    • Eilat, D. & Naparstek, Y. Anti-DNA autoantibodies: a puzzle of autoimmune phenomena. Immunol. Today 20, 339-342 (1999).
    • (1999) Immunol. Today , vol.20 , pp. 339-342
    • Eilat, D.1    Naparstek, Y.2
  • 23
    • 0026612988 scopus 로고
    • Selection of immunoglobulin variable regions in autoimmunity to DNA
    • Marion, T. N., Tillman, D. M., Jou, N. T. & Hill, R. J. Selection of immunoglobulin variable regions in autoimmunity to DNA. Immunol. Rev. 128, 123-149 (1992).
    • (1992) Immunol. Rev. , vol.128 , pp. 123-149
    • Marion, T.N.1    Tillman, D.M.2    Jou, N.T.3    Hill, R.J.4
  • 24
    • 84859155555 scopus 로고    scopus 로고
    • Self-recognition and clonal selection: Autoreactivity drives the generation of B cells
    • Herzog, S. & Jumaa, H. Self-recognition and clonal selection: autoreactivity drives the generation of B cells. Curr. Opin. Immunol. 24, 166-172 (2012).
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 166-172
    • Herzog, S.1    Jumaa, H.2
  • 25
    • 70349246999 scopus 로고    scopus 로고
    • Tolerance checkpoints in B-cell development: Johnny B good
    • Tussiwand, R., Bosco, N., Ceredig, R. & Rolink, A. G. Tolerance checkpoints in B-cell development: Johnny B good. Eur. J. Immunol. 39, 2317-2324 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2317-2324
    • Tussiwand, R.1    Bosco, N.2    Ceredig, R.3    Rolink, A.G.4
  • 26
    • 77951621604 scopus 로고    scopus 로고
    • The pre-B cell receptor: Turning autoreactivity into self-defense
    • Vettermann, C. & Jack, H. M. The pre-B cell receptor: turning autoreactivity into self-defense. Trends Immunol. 31, 176-183 (2010).
    • (2010) Trends Immunol. , vol.31 , pp. 176-183
    • Vettermann, C.1    Jack, H.M.2
  • 27
    • 74049110516 scopus 로고    scopus 로고
    • Checkpoints in lymphocyte development and autoimmune disease
    • von Boehmer, H. & Melchers, F. Checkpoints in lymphocyte development and autoimmune disease. Nat. Immunol. 11, 14-20 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 14-20
    • Von Boehmer, H.1    Melchers, F.2
  • 28
    • 48749111345 scopus 로고    scopus 로고
    • Censoring of autoreactive B cell development by the pre-B cell receptor
    • Keenan, R. A. et al. Censoring of autoreactive B cell development by the pre-B cell receptor. Science 321, 696-699 (2008).
    • (2008) Science , vol.321 , pp. 696-699
    • Keenan, R.A.1
  • 29
    • 0035017470 scopus 로고    scopus 로고
    • Negative selection at the pre-BCR checkpoint elicited by human mu heavy chains with unusual CDR3 regions
    • Minegishi, Y. & Conley, M. E. Negative selection at the pre-BCR checkpoint elicited by human mu heavy chains with unusual CDR3 regions. Immunity 14, 631-641 (2001).
    • (2001) Immunity , vol.14 , pp. 631-641
    • Minegishi, Y.1    Conley, M.E.2
  • 30
    • 84927013252 scopus 로고    scopus 로고
    • Surrogate light chain is required for central and peripheral B-cell tolerance and inhibits anti-DNA antibody production by marginal zone B cells
    • Ren, W. et al. Surrogate light chain is required for central and peripheral B-cell tolerance and inhibits anti-DNA antibody production by marginal zone B cells. Eur. J. Immunol. 45, 1228-1237 (2015).
    • (2015) Eur. J. Immunol. , vol.45 , pp. 1228-1237
    • Ren, W.1
  • 31
    • 70450265288 scopus 로고    scopus 로고
    • Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12
    • Ma, C. S. et al. Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. Immunol. Cell Biol. 87, 590-600 (2009).
    • (2009) Immunol. Cell Biol. , vol.87 , pp. 590-600
    • Ma, C.S.1
  • 32
    • 77953275701 scopus 로고    scopus 로고
    • Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides
    • Avalos, A. M. et al. Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. J. Immunol. 183, 6262-6268 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 6262-6268
    • Avalos, A.M.1
  • 33
    • 0041743207 scopus 로고    scopus 로고
    • The toll-like receptor repertoire of human B lymphocytes: Inducible and selective expression of TLR9 and TLR10 in normal and transformed cells
    • Bourke, E., Bosisio, D., Golay, J., Polentarutti, N. & Mantovani, A. The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood 102, 956-963 (2003).
    • (2003) Blood , vol.102 , pp. 956-963
    • Bourke, E.1    Bosisio, D.2    Golay, J.3    Polentarutti, N.4    Mantovani, A.5
  • 34
    • 84860363209 scopus 로고    scopus 로고
    • A germinal center-independent pathway generates unswitched memory B cells early in the primary response
    • Taylor, J. J., Pape, K. A. & Jenkins, M. K. A germinal center-independent pathway generates unswitched memory B cells early in the primary response. J. Exp. Med. 209, 597-606 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 597-606
    • Taylor, J.J.1    Pape, K.A.2    Jenkins, M.K.3
  • 35
    • 74049161267 scopus 로고    scopus 로고
    • Influence of microbial environment on autoimmunity
    • Chervonsky, A. V. Influence of microbial environment on autoimmunity. Nat. Immunol. 11, 28-35 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 28-35
    • Chervonsky, A.V.1
  • 36
    • 0037112050 scopus 로고    scopus 로고
    • Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora
    • Fagarasan, S. et al. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298, 1424-1427 (2002).
    • (2002) Science , vol.298 , pp. 1424-1427
    • Fagarasan, S.1
  • 37
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty, S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29, 621-663 (2011).
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 621-663
    • Crotty, S.1
  • 38
    • 70350492504 scopus 로고    scopus 로고
    • New insights into the differentiation and function of T follicular helper cells
    • King, C. New insights into the differentiation and function of T follicular helper cells. Nat. Rev. Immunol. 9, 757-766 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 757-766
    • King, C.1
  • 40
  • 41
    • 84862908273 scopus 로고    scopus 로고
    • Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers
    • Wang, X. et al. Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers. J. Exp. Med. 208, 2497-2510 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 2497-2510
    • Wang, X.1
  • 42
    • 84922936572 scopus 로고    scopus 로고
    • Pathophysiology of T follicular helper cells in humans and mice
    • Ueno, H., Banchereau, J. & Vinuesa, C. G. Pathophysiology of T follicular helper cells in humans and mice. Nat. Immunol. 16, 142-152 (2015).
    • (2015) Nat. Immunol. , vol.16 , pp. 142-152
    • Ueno, H.1    Banchereau, J.2    Vinuesa, C.G.3
  • 43
    • 84881252552 scopus 로고    scopus 로고
    • T follicular helper cell dynamics in germinal centers
    • Shulman, Z. et al. T follicular helper cell dynamics in germinal centers. Science 341, 673-677 (2013).
    • (2013) Science , vol.341 , pp. 673-677
    • Shulman, Z.1
  • 45
    • 77955898582 scopus 로고    scopus 로고
    • T cells and follicular dendritic cells in germinal center B-cell formation and selection
    • Vinuesa, C. G., Linterman, M. A., Goodnow, C. C. & Randall, K. L. T cells and follicular dendritic cells in germinal center B-cell formation and selection. Immunol. Rev. 237, 72-89 (2010).
    • (2010) Immunol. Rev. , vol.237 , pp. 72-89
    • Vinuesa, C.G.1    Linterman, M.A.2    Goodnow, C.C.3    Randall, K.L.4
  • 46
    • 78650647005 scopus 로고    scopus 로고
    • Cutting edge: Hierarchy of maturity of murine memory B cell subsets
    • Tomayko, M. M., Steinel, N. C., Anderson, S. M. & Shlomchik, M. J. Cutting edge: hierarchy of maturity of murine memory B cell subsets. J. Immunol. 185, 7146-7150 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 7146-7150
    • Tomayko, M.M.1    Steinel, N.C.2    Anderson, S.M.3    Shlomchik, M.J.4
  • 47
    • 0023279238 scopus 로고
    • High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains
    • Bellon, B. et al. High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains. J. Clin. Invest. 79, 1044-1053 (1987).
    • (1987) J. Clin. Invest. , vol.79 , pp. 1044-1053
    • Bellon, B.1
  • 48
    • 0029913818 scopus 로고    scopus 로고
    • Generation and function of natural self-reactive B lymphocytes
    • Chen, X. & Kearney, J. F. Generation and function of natural self-reactive B lymphocytes. Semin. Immunol. 8, 19-27 (1996).
    • (1996) Semin. Immunol. , vol.8 , pp. 19-27
    • Chen, X.1    Kearney, J.F.2
  • 49
    • 0026580511 scopus 로고
    • Developmentally controlled selection of antibody genes: Characterization of individual VH7183 genes and evidence for stage-specific somatic diversification
    • Carlsson, L., Overmo, C. & Holmberg, D. Developmentally controlled selection of antibody genes: characterization of individual VH7183 genes and evidence for stage-specific somatic diversification. Eur. J. Immunol. 22, 71-78 (1992).
    • (1992) Eur. J. Immunol. , vol.22 , pp. 71-78
    • Carlsson, L.1    Overmo, C.2    Holmberg, D.3
  • 50
    • 0027263407 scopus 로고
    • V-region directed selection in differentiating B lymphocytes
    • Huetz, F., Carlsson, L., Tornberg, U. C. & Holmberg, D. V-region directed selection in differentiating B lymphocytes. EMBO J. 12, 1819-1826 (1993).
    • (1993) EMBO J. , vol.12 , pp. 1819-1826
    • Huetz, F.1    Carlsson, L.2    Tornberg, U.C.3    Holmberg, D.4
  • 52
    • 67651102911 scopus 로고    scopus 로고
    • Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions
    • Espeli, M., Mancini, S. J., Breton, C., Poirier, F. & Schiff, C. Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. Blood 113, 5878-5886 (2009).
    • (2009) Blood , vol.113 , pp. 5878-5886
    • Espeli, M.1    Mancini, S.J.2    Breton, C.3    Poirier, F.4    Schiff, C.5
  • 53
    • 77954957121 scopus 로고    scopus 로고
    • N-linked glycosylation selectively regulates autonomous precursor BCR function
    • Ubelhart, R. et al. N-linked glycosylation selectively regulates autonomous precursor BCR function. Nat. Immunol. 11, 759-765 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 759-765
    • Ubelhart, R.1
  • 54
    • 79960707615 scopus 로고    scopus 로고
    • Efficient generation of B lymphocytes by recognition of selfantigens
    • Eschbach, C. et al. Efficient generation of B lymphocytes by recognition of selfantigens. Eur. J. Immunol. 41, 2397-2403 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , pp. 2397-2403
    • Eschbach, C.1
  • 55
    • 27644452293 scopus 로고    scopus 로고
    • Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus
    • Cappione, 3rd A. et al. Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus. J. Clin. Invest. 115, 3205-3216 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 3205-3216
    • Cappione, A.1
  • 56
    • 84887480836 scopus 로고    scopus 로고
    • Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus
    • Richardson, C. et al. Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus. J. Immunol. 191, 4926-4939 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 4926-4939
    • Richardson, C.1
  • 57
    • 0030765923 scopus 로고    scopus 로고
    • Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor
    • ten Boekel, E., Melchers, F. & Rolink, A. G. Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 7, 357-368 (1997).
    • (1997) Immunity , vol.7 , pp. 357-368
    • Ten Boekel, E.1    Melchers, F.2    Rolink, A.G.3
  • 58
    • 47749123498 scopus 로고    scopus 로고
    • Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors
    • Mietzner, B. et al. Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors. Proc. Natl Acad. Sci. USA 105, 9727-9732 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 9727-9732
    • Mietzner, B.1
  • 59
    • 0025373873 scopus 로고
    • Virus-induced autoantibody response to a transgenic viral antigen
    • Zinkernagel, R. M. et al. Virus-induced autoantibody response to a transgenic viral antigen. Nature 345, 68-71 (1990).
    • (1990) Nature , vol.345 , pp. 68-71
    • Zinkernagel, R.M.1
  • 60
    • 21144438325 scopus 로고    scopus 로고
    • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • Vinuesa, C. G. et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435, 452-458 (2005).
    • (2005) Nature , vol.435 , pp. 452-458
    • Vinuesa, C.G.1
  • 61
    • 84875549975 scopus 로고    scopus 로고
    • Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype
    • Baumjohann, D. et al. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity 38, 596-605 (2013).
    • (2013) Immunity , vol.38 , pp. 596-605
    • Baumjohann, D.1
  • 62
    • 67349120686 scopus 로고    scopus 로고
    • Genetic susceptibility to SLE: New insights from fine mapping and genomewide association studies
    • Harley, I. T. W., Kaufman, K. M., Langefeld, C. D., Harley, J. B. & Kelly, J. A. Genetic susceptibility to SLE: new insights from fine mapping and genomewide association studies. Nat. Rev. Genet. 10, 285-290 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 285-290
    • Harley, I.T.W.1    Kaufman, K.M.2    Langefeld, C.D.3    Harley, J.B.4    Kelly, J.A.5
  • 63
    • 79956335923 scopus 로고    scopus 로고
    • The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis
    • Yim, S. H. et al. The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis. Mol. Immunol. 48, 1338-1343 (2011).
    • (2011) Mol. Immunol. , vol.48 , pp. 1338-1343
    • Yim, S.H.1
  • 64
    • 0037097681 scopus 로고    scopus 로고
    • VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus
    • Shimizu, T., Mundt, C., Licence, S., Melchers, F. & Martensson, I. L. VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J. Immunol. 168, 6286-6293 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 6286-6293
    • Shimizu, T.1    Mundt, C.2    Licence, S.3    Melchers, F.4    Martensson, I.L.5
  • 65
    • 80055071471 scopus 로고    scopus 로고
    • Requirement for complement in antibody responses is not explained by the classic pathway activator IgM
    • Rutemark, C. et al. Requirement for complement in antibody responses is not explained by the classic pathway activator IgM. Proc. Natl Acad. Sci. USA 108, E934-E942 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. E934-E942
    • Rutemark, C.1
  • 66
    • 70349750487 scopus 로고    scopus 로고
    • Cloning and expression of murine Ig genes from single B cells
    • Tiller, T., Busse, C. E. & Wardemann, H. Cloning and expression of murine Ig genes from single B cells. J. Immunol. Methods 350, 183-193 (2009).
    • (2009) J. Immunol. Methods , vol.350 , pp. 183-193
    • Tiller, T.1    Busse, C.E.2    Wardemann, H.3
  • 67
    • 48449094247 scopus 로고    scopus 로고
    • IMGT/V-QUEST: The highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
    • Brochet, X., Lefranc, M. P. & Giudicelli, V. IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 36, W503-W508 (2008).
    • (2008) Nucleic Acids Res. , vol.36 , pp. W503-W508
    • Brochet, X.1    Lefranc, M.P.2    Giudicelli, V.3
  • 68
    • 84874137715 scopus 로고    scopus 로고
    • Immunoglobulin analysis tool: A novel tool for the analysis of human and mouse heavy and light chain transcripts
    • Rogosch, T. et al. Immunoglobulin analysis tool: a novel tool for the analysis of human and mouse heavy and light chain transcripts. Front. Immunol. doi:10.3389/fimmu.2012.00176 (2012).
    • (2012) Front. Immunol.
    • Rogosch, T.1


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