Pi-pi stacking mediated cooperative mechanism for human cytochrome P450 3A4

Molecules

Volumn 20, Issue 5, 2015, Pages 7558-7573

  Fa, Botao ^a   Cong, Shan ^b   Wang, Jingfang ^a  

^a Shanghai Jiao Tong University   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Cooperative binding; Cytochrome p450; Drug metabolism; Pi pi stacking

Indexed keywords

ANTIFUNGAL AGENT; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; KETOCONAZOLE; PROTEIN BINDING;

BINDING SITE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR DYNAMICS; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

ANTIFUNGAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP3A; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KETOCONAZOLE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING;

EID: 84929193139     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20057558     Document Type: Article

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