Interventricular differences in β-adrenergic responses in the canine heart: Role of phosphodiesterases

Journal of the American Heart Association

Volumn 3, Issue 3, 2014, Pages

  Molina, Cristina E ^a,b   Johnson, Daniel M ^a,c   Mehel, Hind ^a,b   Spätjens, Roel L H M G ^c   Mika, Delphine ^a,b   Algalarrondo, Vincent ^a,b   Slimane, Zeineb Haj ^a,b   Lechêne, Patrick ^a,b   Abi Gerges, Najah ^d   van der Linde, Henk J ^e   Leroy, Jérôme ^a,b   Volders, Paul G A ^c   Fischmeister, Rodolphe ^a,b   Vandecasteele, Grégoire ^a,b  

^a Universite Paris Sud   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d ASTRAZENECA   (United Kingdom)

^e JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

B adrenergic stimulation; cAMP; Dog; Heart ventricles; Phosphodiesterases

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV; BETA ADRENERGIC RECEPTOR; CALCIUM; CYCLIC AMP;

ADRENERGIC SYSTEM; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEAGLE; BETA ADRENERGIC STIMULATION; CELL ISOLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; FEMALE; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART RIGHT VENTRICLE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SARCOMERE LENGTH; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; ANIMAL; CARDIAC MUSCLE CELL; DOG; DRUG EFFECTS; ENZYMOLOGY; HEART; HEART VENTRICLE; HEART VENTRICLE FUNCTION; METABOLISM; PHYSIOLOGY; SARCOMERE;

ANIMALS; CALCIUM; CYCLIC AMP; DOGS; FEMALE; HEART; HEART VENTRICLES; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PHOSPHORIC DIESTER HYDROLASES; RECEPTORS, ADRENERGIC, BETA; SARCOMERES; VENTRICULAR FUNCTION;

EID: 84929142384     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.114.000858     Document Type: Article

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