메뉴 건너뛰기




Volumn 187, Issue 1, 2013, Pages 14-19

Neurohormonal axis in patients with pulmonary arterial hypertension: Friend or foe?

Author keywords

Pulmonary hypertension; Renin angiotensin system; Sympathetic nervous system

Indexed keywords

[1 [(2 DIMETHYLAMINO)ETHYLAMINO] 4 (HYDROXYMETHYL) 7 [(4 METHYLPHENYL)SULFONYLOXY] 9H XANTHENE 9 ONE]; ALDOSTERONE ANTAGONIST; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; ATRIAL NATRIURETIC FACTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; BRAIN NATRIURETIC PEPTIDE; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; NEUROHORMONE; NORADRENALIN; UNCLASSIFIED DRUG;

EID: 84872001689     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201209-1663PP     Document Type: Review
Times cited : (77)

References (50)
  • 1
    • 77649228421 scopus 로고    scopus 로고
    • Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: Lessons from the left heart
    • Handoko ML, de Man FS, Allaart CP, Paulus WJ, Westerhof N, Vonk-Noordegraaf A. Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: lessons from the left heart. Eur Respir Rev 2010;19:72-82.
    • (2010) Eur Respir Rev , vol.19 , pp. 72-82
    • Handoko, M.L.1    De Man, F.S.2    Allaart, C.P.3    Paulus, W.J.4    Westerhof, N.5    Vonk-Noordegraaf, A.6
  • 4
    • 38649137299 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system
    • DOI 10.1016/j.bcp.2007.08.012, PII S0006295207005540
    • Lambert DW, Hooper NM, Turner AJ. Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system. Biochem Pharmacol 2008;75:781-786. (Pubitemid 351174108)
    • (2008) Biochemical Pharmacology , vol.75 , Issue.4 , pp. 781-786
    • Lambert, D.W.1    Hooper, N.M.2    Turner, A.J.3
  • 5
    • 0022980843 scopus 로고
    • 1-receptor down-regulation in heart failure
    • Bristow MR, Ginsburg R, Umans V, Fowler M, Minobe W, Rasmussen R, Zera P, Menlove R, Shah P, Jamiezon S. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contr.action and selective beta 1-receptor down-regulation in heart failure. Circ Res 1986;59:297-309. (Pubitemid 17178124)
    • (1986) Circulation Research , vol.59 , Issue.3 , pp. 297-309
    • Bristow, M.R.1    Ginsburg, R.2    Umans, V.3
  • 6
    • 0026440047 scopus 로고
    • Short- And long-term hemodynamic effects of captopril in patients with pulmonary hypertension and selected connective tissue disease
    • Alpert MA, Pressly TA, Mukerji V, Lambert CR, Mukerji B. Short- and long-term hemodynamic effects of captopril in patients with pulmonary hypertension and selected connective tissue disease. Chest 1992;102:1407-1412.
    • (1992) Chest , vol.102 , pp. 1407-1412
    • Alpert, M.A.1    Pressly, T.A.2    Mukerji, V.3    Lambert, C.R.4    Mukerji, B.5
  • 7
    • 0020684116 scopus 로고
    • Captopril in primary pulmonary hypertension
    • Leier CV, Bambach D, Nelson S, Hermiller JB, Huss P, Magorien RD, Unverferth DV. Captopril in primary pulmonary hypertension. Circulation 1983;67:155-161. (Pubitemid 13222085)
    • (1983) Circulation , vol.67 , Issue.1 , pp. 155-161
    • Leier, C.V.1    Bambach, D.2    Nelson, S.3
  • 8
    • 0020459780 scopus 로고
    • Haemodynamic and hormonal effects of captopril in primary pulmonary hypertension
    • Ikram H, Maslowski AH, Nicholls MG, Espiner EA, Hull FT. Haemodynamic and hormonal effects of captopril in primary pulmonary hypertension. Br Heart J 1982;48:541-545. (Pubitemid 13217289)
    • (1982) British Heart Journal , vol.48 , Issue.6 , pp. 541-545
    • Ikram, H.1    Maslowski, A.H.2    Nicholls, M.G.3
  • 11
    • 4444288196 scopus 로고    scopus 로고
    • Increased sympathetic nerve activity in pulmonary artery hypertension
    • DOI 10.1161/01.CIR.0000140724.90898.D3
    • Velez-Roa S, Ciarka A, Najem B, Vachiery J-L, Naeije R, van de Borne P. Increased sympathetic nerve activity in pulmonary artery hypertension. Circulation 2004;110:1308-1312. (Pubitemid 39202350)
    • (2004) Circulation , vol.110 , Issue.10 , pp. 1308-1312
    • Velez-Roa, S.1    Ciarka, A.2    Najem, B.3    Vachiery, J.-L.4    Naeije, R.5    Van De, B.P.6
  • 12
    • 65549141178 scopus 로고    scopus 로고
    • Discordance between microneurographic and heart-rate spectral indices of sympathetic activity in pulmonary arterial hypertension
    • McGowan CL, Swiston JS, Notarius CF, Mak S, Morris BL, Picton PE, Granton JT, Floras JS. Discordance between microneurographic and heart-rate spectral indices of sympathetic activity in pulmonary arterial hypertension. Heart 2009;95:754-758.
    • (2009) Heart , vol.95 , pp. 754-758
    • McGowan, C.L.1    Swiston, J.S.2    Notarius, C.F.3    Mak, S.4    Morris, B.L.5    Picton, P.E.6    Granton, J.T.7    Floras, J.S.8
  • 14
    • 0028788150 scopus 로고
    • Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: Relation to hemodynamic variables and endothelin levels
    • Nootens M, Kaufmann E, Rector T, Toher C, Judd D, Francis GS, Rich S. Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: relation to hemodynamic variables and endothelin levels. J Am Coll Cardiol 1995;26:1581-1585.
    • (1995) J Am Coll Cardiol , vol.26 , pp. 1581-1585
    • Nootens, M.1    Kaufmann, E.2    Rector, T.3    Toher, C.4    Judd, D.5    Francis, G.S.6    Rich, S.7
  • 16
    • 34250809614 scopus 로고    scopus 로고
    • Atrial septostomy decreases sympathetic overactivity in pulmonary arterial hypertension
    • DOI 10.1378/chest.06-2903
    • Ciarka A, Vachièry J-L, Houssière A, Gujic M, Stoupel E, Velez-Roa S, Naeije R, van de Borne P. Atrial septostomy decreases sympathetic overactivity in pulmonary arterial hypertension. Chest 2007;131:1831-1837. (Pubitemid 46981642)
    • (2007) Chest , vol.131 , Issue.6 , pp. 1831-1837
    • Ciarka, A.1    Vachiery, J.-L.2    Houssiere, A.3    Gujic, M.4    Stoupel, E.5    Velez-Roa, S.6    Naeije, R.7    Van De, B.P.8
  • 17
    • 77954722604 scopus 로고    scopus 로고
    • Prognostic significance of sympathetic nervous system activation in pulmonary arterial hypertension
    • Ciarka A, Doan V, Velez-Roa S, Naeije R, van de Borne P. Prognostic significance of sympathetic nervous system activation in pulmonary arterial hypertension. Am J Respir Crit Care Med 2010;181:1269-1275.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 1269-1275
    • Ciarka, A.1    Doan, V.2    Velez-Roa, S.3    Naeije, R.4    Van De Borne, P.5
  • 19
    • 70349642998 scopus 로고    scopus 로고
    • Clinical relevance of autonomic nervous system disturbances in pulmonary arterial hypertension
    • Naeije R, van de Borne P. Clinical relevance of autonomic nervous system disturbances in pulmonary arterial hypertension. Eur Respir J 2009;34:792-794.
    • (2009) Eur Respir J , vol.34 , pp. 792-794
    • Naeije, R.1    Van De Borne, P.2
  • 20
    • 34248158605 scopus 로고    scopus 로고
    • Prognostic value of blood gas analyses in patients with idiopathic pulmonary arterial hypertension
    • DOI 10.1183/09031936.00134506
    • Hoeper MM, Pletz MW, Golpon H, Welte T. Prognostic value of blood gas analyses in patients with idiopathic pulmonary arterial hypertension. Eur Respir J 2007;29:944-950. (Pubitemid 46711899)
    • (2007) European Respiratory Journal , vol.29 , Issue.5 , pp. 944-950
    • Hoeper, M.M.1    Pletz, M.W.2    Golpon, H.3    Welte, T.4
  • 21
    • 0035943014 scopus 로고    scopus 로고
    • Exercise pathophysiology in patients with primary pulmonary hypertension
    • Sun XG, Hansen JE, Oudiz RJ,Wasserman K. Exercise pathophysiology in patients with primary pulmonary hypertension. Circulation 2001;104:429-435. (Pubitemid 32678273)
    • (2001) Circulation , vol.104 , Issue.4 , pp. 429-435
    • Sun, X.-G.1    Hansen, J.E.2    Oudiz, R.J.3    Wasserman, K.4
  • 25
    • 0033645470 scopus 로고    scopus 로고
    • Expression of pulmonary vascular angiotensin-converting enzyme in primary and secondary plexiform pulmonary hypertension
    • Orte C, Polak JM, Haworth SG, Yacoub MH, Morrell NW. Expression of pulmonary vascular angiotensin-converting enzyme in primary and secondary plexiform pulmonary hypertension. J Pathol 2000;192:379-384.
    • (2000) J Pathol , vol.192 , pp. 379-384
    • Orte, C.1    Polak, J.M.2    Haworth, S.G.3    Yacoub, M.H.4    Morrell, N.W.5
  • 29
    • 0033178254 scopus 로고    scopus 로고
    • Interactions between endothelin-1 and the renin-angiotensin-aldosterone system
    • DOI 10.1016/S0008-6363(99)00110-8, PII S0008636399001108
    • Rossi GP, Sacchetto A, Cesari M, Pessina AC. Interactions between endothelin-1 and the renin-angiotensin-aldosterone system. Cardiovasc Res 1999;43:300-307. (Pubitemid 29356368)
    • (1999) Cardiovascular Research , vol.43 , Issue.2 , pp. 300-307
    • Rossi, G.P.1    Sacchetto, A.2    Cesari, M.3    Pessina, A.C.4
  • 31
    • 73349121953 scopus 로고    scopus 로고
    • Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats
    • Ishikawa M, Sato N, Asai K, Takano T, Mizuno K. Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats. Circ J 2009;73:2337-2341.
    • (2009) Circ J , vol.73 , pp. 2337-2341
    • Ishikawa, M.1    Sato, N.2    Asai, K.3    Takano, T.4    Mizuno, K.5
  • 32
    • 33748674457 scopus 로고    scopus 로고
    • Upregulated neurohumoral factors are associated with left ventricular remodeling and poor prognosis in rats with monocrotaline-induced pulmonary arterial hypertension
    • DOI 10.1253/circj.70.1208
    • Usui S, Yao A, Hatano M, Kohmoto O, Takahashi T, Nagai R, Kinugawa K. Upregulated neurohumoral factors are associated with left ventricular remodeling and poor prognosis in rats with monocrotaline-induced pulmonary arterial hypertension. Circ J 2006;70:1208-1215. (Pubitemid 44387006)
    • (2006) Circulation Journal , vol.70 , Issue.9 , pp. 1208-1215
    • Usui, S.-I.1    Yao, A.2    Hatano, M.3    Kohmoto, O.4    Takahashi, T.5    Nagai, R.6    Kinugawa, K.7
  • 36
    • 70350509631 scopus 로고    scopus 로고
    • Effects of telmisartan on right ventricular remodeling induced by monocrotaline in rats
    • Okada M, Harada T, Kikuzuki R, Yamawaki H, Hara Y. Effects of telmisartan on right ventricular remodeling induced by monocrotaline in rats. J Pharmacol Sci 2009;111:193-200.
    • (2009) J Pharmacol Sci , vol.111 , pp. 193-200
    • Okada, M.1    Harada, T.2    Kikuzuki, R.3    Yamawaki, H.4    Hara, Y.5
  • 38
    • 0035928756 scopus 로고    scopus 로고
    • Cardioprotective effects of ramipril and losartan in right ventricular pressure overload in the rabbit: Importance of kinins and influence on angiotensin II type 1 receptor signaling pathway
    • Rouleau JL, Kapuku G, Pelletier S, Gosselin H, Adam A, Gagnon C, Lambert C, Meloche S. Cardioprotective effects of ramipril and losartan in right ventricular pressure overload in the rabbit: importance of kinins and influence on angiotensin II type 1 receptor signaling pathway. Circulation 2001;104:939-944. (Pubitemid 32778047)
    • (2001) Circulation , vol.104 , Issue.8 , pp. 939-944
    • Rouleau, J.L.1    Kapuku, G.2    Pelletier, S.3    Gosselin, H.4    Adam, A.5    Gagnon, C.6    Lambert, C.7    Meloche, S.8
  • 40
    • 84865214267 scopus 로고    scopus 로고
    • Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension
    • Maron BA, Zhang Y-Y, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation 2012;126:963-974.
    • (2012) Circulation , vol.126 , pp. 963-974
    • Maron, B.A.1    Zhang, Y.-Y.2    White, K.3    Chan, S.Y.4    Handy, D.E.5    Mahoney, C.E.6    Loscalzo, J.7    Leopold, J.A.8
  • 42
    • 79958734872 scopus 로고    scopus 로고
    • ACE2 improves right ventricular function in a pressure overload model
    • Johnson JA, West J, Maynard KB, Hemnes AR. ACE2 improves right ventricular function in a pressure overload model. PLoS ONE 2011;6:e20828.
    • (2011) PLoS ONE , vol.6
    • Johnson, J.A.1    West, J.2    Maynard, K.B.3    Hemnes, A.R.4
  • 48
    • 77951983157 scopus 로고    scopus 로고
    • Pulmonary hypertension: A contraindication to the use of β-adrenoceptor blocking agents
    • Peacock A, Ross K. Pulmonary hypertension: a contraindication to the use of β-adrenoceptor blocking agents. Thorax 2010;65:454-455.
    • (2010) Thorax , vol.65 , pp. 454-455
    • Peacock, A.1    Ross, K.2
  • 50
    • 0026786643 scopus 로고
    • Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial
    • The SAVE Investigators
    • Pfeffer MA, Braunwald E, Moyé LA, Basta L, Brown EJ Jr, Cuddy TE, Davis BR, Geltman EM, Goldman S, Glaker GC, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med 1992;327:669-677.
    • (1992) N Engl J Med , vol.327 , pp. 669-677
    • Pfeffer, M.A.1    Braunwald, E.2    Moyé, L.A.3    Basta, L.4    Brown Jr., E.J.5    Cuddy, T.E.6    Davis, B.R.7    Geltman, E.M.8    Goldman, S.9    Glaker, G.C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.