Intestinal epithelial TLR-4 activation is required for the development of acute lung injury after trauma/hemorrhagic shock via the release of HMGB1 from the gut

Journal of Immunology

Volumn 194, Issue 10, 2015, Pages 4931-4939

  Sodhi, Chhinder P ^a   Jia, Hongpeng ^a   Yamaguchi, Yukihiro ^a   Lu, Peng ^a   Good, Misty ^b,c   Egan, Charlotte ^a   Ozolek, John ^b,c   Zhu, Xiaorong ^d   Billiar, Timothy R ^c   Hackam, David J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; PROTEIN KINASE C ZETA; TOLL LIKE RECEPTOR 4; HMGB1 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOPLASMIC RETICULUM STRESS; HEMORRHAGIC SHOCK; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTERNALIZATION; INTESTINE CELL; INTESTINE EPITHELIUM; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; TIGHT JUNCTION; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL LINE; COMPLICATION; DISEASE MODEL; IMMUNOLOGY; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM;

ACUTE LUNG INJURY; ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; HMGB1 PROTEIN; HUMANS; INTESTINAL MUCOSA; MICE; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; SHOCK, HEMORRHAGIC; TOLL-LIKE RECEPTOR 4;

EID: 84929121038     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402490     Document Type: Article

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