Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/Calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward ras and rap GTPases

Journal of Biological Chemistry

Volumn 290, Issue 8, 2015, Pages 4908-4927

  Walkup, Ward G ^a   Washburn, Lorraine ^a   Sweredoski, Michael J ^b   Carlisle, Holly J ^a   Graham, Robert L ^b   Hess, Sonja ^b   Kennedy, Mary B ^a  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; PHOSPHORYLATION;

CYCLIN-DEPENDENT KINASE; GTPASE-ACTIVATING PROTEIN; GTPASES; PROTEIN KINASE;

CALCIUM COMPOUNDS;

CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIN DEPENDENT KINASE 5; GLUTAMATE RECEPTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; N METHYL DEXTRO ASPARTIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; RAP1 GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAP2 GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; SERINE; SYNAPTIC GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; UNCLASSIFIED DRUG; CDK5 PROTEIN, HUMAN; CDK5 PROTEIN, RAT; HRAS PROTEIN, HUMAN; HRAS PROTEIN, RAT; KRAS2 PROTEIN, MOUSE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; ONCOPROTEIN; PROTEIN P21; RAP PROTEIN; RAP1 PROTEIN; RAP2A PROTEIN, HUMAN; RAS PROTEIN; SYNGAP1 PROTEIN, HUMAN; SYNGAP1 PROTEIN, MOUSE; SYNGAP1 PROTEIN, RAT;

ADULT; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; MALE; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STOICHIOMETRY; UPREGULATION; ANIMAL; CELL CULTURE; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; NERVE CELL; PHOSPHORYLATION; RAT; SYNAPSE;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; GTPASE-ACTIVATING PROTEINS; HUMANS; NEURONS; ONCOGENE PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS P21(RAS); RAP GTP-BINDING PROTEINS; RAP1 GTP-BINDING PROTEINS; RAS GTPASE-ACTIVATING PROTEINS; RAS PROTEINS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

EID: 84929095311     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.614420     Document Type: Article

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