Autoactivation of human ADAM8: A novel preprocessing step is required for catalytic activity

Bioscience Reports

Volumn 29, Issue 4, 2009, Pages 217-228

  Hall, Troii ^a   Leone, Joseph W ^a   Wiese, Joseph F ^a   Griggs, David W ^a   Pegg, Lyle E ^a   Pauley, Adele M ^a   Tomasselli, Alfredo G ^a   Zack, Marc D ^a  

^a PFIZER INC   (United States)

Author keywords

A disintegrin and metalloproteinase 8 (ADAM8); Autoactivation; Catalytic activity; Disintegrin; Pro protein convertase (PC)

Indexed keywords

A DISINTEGRIN AND METALLOPROTEINASE 8; ADAM PROTEIN; CYSTEINE; DISINTEGRIN; ENTEROPEPTIDASE; EPIDERMAL GROWTH FACTOR; GLUTAMIC ACID; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; ADAM8 PROTEIN, HUMAN; MEMBRANE PROTEIN; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DISULFIDE BOND; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; INCUBATION TIME; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PURIFICATION; SEQUENCE ANALYSIS; STABLE EXPRESSION; STRUCTURE ACTIVITY RELATION; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ADAM PROTEINS; CATALYSIS; CATALYTIC DOMAIN; ENZYME ACTIVATION; HUMANS; MEMBRANE PROTEINS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, PROTEIN;

EID: 70349780860     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSR20080145     Document Type: Article

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