Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism

Laboratory Investigation

Volumn 95, Issue 5, 2015, Pages 515-524

  Teranishi, Yuga ^a   Matsubara, Tsutomu ^a   Krausz, Kristopher W ^b   Le, Thi T T ^a   Gonzalez, Frank J ^b   Yoshizato, Katsutoshi ^a,c   Ikeda, Kazuo ^a   Kawada, Norifumi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

^c PhoenixBio USA Corporation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CYTOCHROME P450 2E1; CYTOGLOBIN; DRUG METABOLITE; GALACTOSAMINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; OXYGEN; PARACETAMOL; PIMONIDAZOLE; TUMOR NECROSIS FACTOR ALPHA; XENOBIOTIC AGENT; GLOBIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBON TETRACHLORIDE-INDUCED LIVER FIBROSIS; CELL DEATH; CELL FRACTIONATION; CELL PROTECTION; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; DRUG METABOLISM; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CULTURE; LIVER CELL DAMAGE; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MEASUREMENT; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; STELLATE CELL; WESTERN BLOTTING; XENOBIOTIC METABOLISM; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; GENETICS; LIVER; METABOLISM; TOXIC HEPATITIS; TRANSGENIC MOUSE;

ACETAMINOPHEN; ANIMALS; CARBON TETRACHLORIDE; CYTOCHROME P-450 CYP2E1; DRUG-INDUCED LIVER INJURY; GLOBINS; HEPATIC STELLATE CELLS; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXYGEN; XENOBIOTICS;

EID: 84929081387     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2015.29     Document Type: Article

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