메뉴 건너뛰기




Volumn 4, Issue 3, 2011, Pages 233-235

Prospects for a hepcidin mimic to treat β-thalassemia and hemochromatosis

Author keywords

thalassemia; anemia; hemochromatosis; hepcidin; ineffective erythropoiesis; iron overload; splenomegaly

Indexed keywords

FERROPORTIN; HEPCIDIN; HEPCIDIN AGONIST; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 79959262524     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/ehm.11.22     Document Type: Review
Times cited : (14)

References (20)
  • 1
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu. Rev. Med. 62, 347-360 (2011)
    • (2011) Annu. Rev. Med. , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 2
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38(5), 531-539 (2006)
    • (2006) Nat. Genet. , vol.38 , Issue.5 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3
  • 3
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through stat3
    • Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood 108(9), 3204-3209 (2006)
    • (2006) Blood , vol.108 , Issue.9 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 4
    • 77953525651 scopus 로고    scopus 로고
    • Oncostatin M is a potent inducer of hepcidin the iron regulatory hormone
    • Chung B, Verdier F, Matak P, Deschemin JC, Maueux P, Vaulont S. Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone. FASEB J. 24(6), 2093-2103 (2010)
    • (2010) FASEB J. , vol.24 , Issue.6 , pp. 2093-2103
    • Chung, B.1    Verdier, F.2    Matak, P.3    Deschemin, J.C.4    Maueux, P.5    Vaulont, S.6
  • 5
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 108(12), 3730-3735 (2006)
    • (2006) Blood , vol.108 , Issue.12 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3    Ganz, T.4    Rivera, S.5
  • 6
    • 34948904750 scopus 로고    scopus 로고
    • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    • Tanno T, Bhanu NV, Oneal PA et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med. 13(9), 1096-1101 (2007)
    • (2007) Nat. Med. , vol.13 , Issue.9 , pp. 1096-1101
    • Tanno, T.1    Bhanu, N.V.2    Oneal, P.A.3
  • 7
    • 77954611973 scopus 로고    scopus 로고
    • Iron loading and overloading due to ineffective erythropoiesis
    • Tanno T, Miller JL. Iron loading and overloading due to ineffective erythropoiesis. Adv. Hematol. 2010, 358283 (2010)
    • (2010) Adv. Hematol. , vol.2010 , pp. 358283
    • Tanno, T.1    Miller, J.L.2
  • 8
    • 67651043722 scopus 로고    scopus 로고
    • Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells
    • Tanno T, Porayette P, Sripichai O et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 114(1), 181-186 (2009)
    • (2009) Blood , vol.114 , Issue.1 , pp. 181-186
    • Tanno, T.1    Porayette, P.2    Sripichai, O.3
  • 9
    • 78649813036 scopus 로고    scopus 로고
    • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
    • Gardenghi S, Ramos P, Marongiu MF et al. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. J. Clin. Invest. 120(12), 4466-4477 (2010)
    • (2010) J. Clin. Invest. , vol.120 , Issue.12 , pp. 4466-4477
    • Gardenghi, S.1    Ramos, P.2    Marongiu, M.F.3
  • 10
    • 77956928344 scopus 로고    scopus 로고
    • Transfusion independence and HMGA2 activation after gene therapy of human βthalassaemia
    • CavazzanαCalvo M, Payen E, Negre O et al. Transfusion independence and HMGA2 activation after gene therapy of human βthalassaemia. Nature 467(7313), 318-322 (2010)
    • (2010) Nature , vol.467 , Issue.7313 , pp. 318-322
    • Cavazzan-Calvo, M.1    Payen, E.2    Negre, O.3
  • 11
    • 77955508573 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Pathogenesis diagnosis and treatment
    • Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 139(2), 393-408 (2010)
    • (2010) Gastroenterology , vol.139 , Issue.2 , pp. 393-408
    • Pietrangelo, A.1
  • 13
    • 76349118307 scopus 로고    scopus 로고
    • Transferrin therapy ameliorates disease in b-thalassemic mice
    • Li H, Rybicki AC, Suzuka SM et al. Transferrin therapy ameliorates disease in b-thalassemic mice. Nat. Med. 16(2), 177-182 (2010)
    • (2010) Nat. Med. , vol.16 , Issue.2 , pp. 177-182
    • Li, H.1    Rybicki, A.C.2    Suzuka, S.M.3
  • 14
    • 77952590062 scopus 로고    scopus 로고
    • Hepcidin treatment in Hfe-/- mice diminishes plasma iron without affecting erythropoiesis
    • Moran-Jimenez MJ, Mendez M, Santiago B et al. Hepcidin treatment in Hfe-/- mice diminishes plasma iron without affecting erythropoiesis. Eur. J. Clin. Invest. 40(6), 511-517 (2010)
    • (2010) Eur. J. Clin. Invest. , vol.40 , Issue.6 , pp. 511-517
    • Moran-Jimenez, M.J.1    Mendez, M.2    Santiago, B.3
  • 15
    • 33645525540 scopus 로고    scopus 로고
    • Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice
    • Viatte L, Nicolas G, Lou DQ et al. Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. Blood 107(7), 2952-2958 (2006)
    • (2006) Blood , vol.107 , Issue.7 , pp. 2952-2958
    • Viatte, L.1    Nicolas, G.2    Lou, D.Q.3
  • 16
    • 0037847496 scopus 로고    scopus 로고
    • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
    • Nicolas G, Viatte L, Lou DQ et al. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat. Genet. 34(1), 97-101 (2003)
    • (2003) Nat. Genet. , vol.34 , Issue.1 , pp. 97-101
    • Nicolas, G.1    Viatte, L.2    Lou, D.Q.3
  • 17
    • 78049463632 scopus 로고    scopus 로고
    • BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice
    • Corradini E, Schmidt PJ, Meynard D et al. BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology 139(5), 1721-1729 (2010)
    • (2010) Gastroenterology , vol.139 , Issue.5 , pp. 1721-1729
    • Corradini, E.1    Schmidt, P.J.2    Meynard, D.3
  • 19
    • 78649634981 scopus 로고    scopus 로고
    • Hepcidin in human iron disorders: Therapeutic implications
    • Pietrangelo A. Hepcidin in human iron disorders: therapeutic implications. J. Hepatol. 54(1), 173-181 (2011)
    • (2011) J. Hepatol. , vol.54 , Issue.1 , pp. 173-181
    • Pietrangelo, A.1
  • 20
    • 78149304850 scopus 로고    scopus 로고
    • In anemia of multiple myeloma hepcidin is induced by increased bone morphogenetic protein 2
    • Maes K, Nemeth E, Roodman GD et al. In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood 116(18), 3635-3644 (2010).
    • (2010) Blood , vol.116 , Issue.18 , pp. 3635-3644
    • Maes, K.1    Nemeth, E.2    Roodman, G.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.