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Volumn 125, Issue 5, 2015, Pages 2123-2135

Estrogen regulates Hippo signaling via GPER in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; PROGESTERONE RECEPTOR; PROTEIN; TAZ PROTEIN; UNCLASSIFIED DRUG; YAP PROTEIN; GPER PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HIPPO PROTEIN, HUMAN; LATS1 PROTEIN, HUMAN; PHOSPHOLIPASE C BETA; PHOSPHOPROTEIN; PLCB1 PROTEIN, HUMAN; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; RHO KINASE; ROCK1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STK3 PROTEIN, HUMAN; STK4 PROTEIN, HUMAN; TAZ PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

EID: 84928984549     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI79573     Document Type: Article
Times cited : (182)

References (50)
  • 1
    • 0035878743 scopus 로고    scopus 로고
    • Estrogen receptor interaction with estrogen response elements
    • Klinge CM. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res. 2001;29(14):2905-2919.
    • (2001) Nucleic Acids Res , vol.29 , Issue.14 , pp. 2905-2919
    • Klinge, C.M.1
  • 2
    • 0037204724 scopus 로고    scopus 로고
    • Connections and regulation of the human estrogen receptor
    • McDonnell DP, Norris JD. Connections and regulation of the human estrogen receptor. Science. 2002;296(5573):1642-1644.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1642-1644
    • McDonnell, D.P.1    Norris, J.D.2
  • 3
    • 0031282001 scopus 로고    scopus 로고
    • Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer
    • Carmeci C, Thompson DA, Ring HZ, Francke U, Weigel RJ. Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. Genomics. 1997;45(3):607-617.
    • (1997) Genomics , vol.45 , Issue.3 , pp. 607-617
    • Carmeci, C.1    Thompson, D.A.2    Ring, H.Z.3    Francke, U.4    Weigel, R.J.5
  • 4
    • 14844343093 scopus 로고    scopus 로고
    • A transmembrane intracellular estrogen receptor mediates rapid cell signaling
    • Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science. 2005;307(5715):1625-1630.
    • (2005) Science , vol.307 , Issue.5715 , pp. 1625-1630
    • Revankar, C.M.1    Cimino, D.F.2    Sklar, L.A.3    Arterburn, J.B.4    Prossnitz, E.R.5
  • 5
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam RT, Gutkind JS. G-protein-coupled receptors and cancer. Nat Rev Cancer. 2007;7(2):79-94.
    • (2007) Nat Rev Cancer , vol.7 , Issue.2 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 6
    • 84878219891 scopus 로고    scopus 로고
    • The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
    • O'Hayre M, et al. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer. 2013;13(6):412-424.
    • (2013) Nat Rev Cancer , vol.13 , Issue.6 , pp. 412-424
    • O'Hayre, M.1
  • 7
    • 0033780783 scopus 로고    scopus 로고
    • Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    • Filardo EJ, Quinn JA, Bland KI, Frackelton AR, Frackelton AR Jr. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol. 2000;14(10):1649-1660.
    • (2000) Mol Endocrinol , vol.14 , Issue.10 , pp. 1649-1660
    • Filardo, E.J.1    Quinn, J.A.2    Bland, K.I.3    Frackelton, A.R.4    Frackelton, A.R.5
  • 8
    • 3042547161 scopus 로고    scopus 로고
    • The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17β-estradiol and phytoestrogens in breast cancer cells
    • Maggiolini M, et al. The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17β-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004;279(26):27008-27016.
    • (2004) J Biol Chem , vol.279 , Issue.26 , pp. 27008-27016
    • Maggiolini, M.1
  • 9
    • 62049084027 scopus 로고    scopus 로고
    • Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF
    • Pandey DP, Lappano R, Albanito L, Madeo A, Maggiolini M, Picard D. Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. EMBO J. 2009;28(5):523-532.
    • (2009) EMBO J , vol.28 , Issue.5 , pp. 523-532
    • Pandey, D.P.1    Lappano, R.2    Albanito, L.3    Madeo, A.4    Maggiolini, M.5    Picard, D.6
  • 10
    • 33847755409 scopus 로고    scopus 로고
    • G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells
    • Albanito L, et al. G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res. 2007;67(4):1859-1866.
    • (2007) Cancer Res , vol.67 , Issue.4 , pp. 1859-1866
    • Albanito, L.1
  • 11
    • 33344461590 scopus 로고    scopus 로고
    • The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17β-estradiol and hydroxytamoxifen in endometrial cancer cells
    • Vivacqua A, et al. The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17β-estradiol and hydroxytamoxifen in endometrial cancer cells. Mol Endocrinol. 2006;20(3):631-646.
    • (2006) Mol Endocrinol , vol.20 , Issue.3 , pp. 631-646
    • Vivacqua, A.1
  • 12
    • 79959770197 scopus 로고    scopus 로고
    • G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer
    • Ignatov A, et al. G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer. Breast Cancer Res Treat. 2011;128(2):457-466.
    • (2011) Breast Cancer Res Treat , vol.128 , Issue.2 , pp. 457-466
    • Ignatov, A.1
  • 13
    • 33751272253 scopus 로고    scopus 로고
    • Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression
    • Filardo EJ, et al. Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression. Clin Cancer Res. 2006;12(21):6359-6366.
    • (2006) Clin Cancer Res , vol.12 , Issue.21 , pp. 6359-6366
    • Filardo, E.J.1
  • 14
    • 34547789280 scopus 로고    scopus 로고
    • The interactions between GPR30 and the major biomarkers in infiltrating ductal carcinoma of the breast in an Asian population
    • Kuo WH, et al. The interactions between GPR30 and the major biomarkers in infiltrating ductal carcinoma of the breast in an Asian population. Taiwan J Obstet Gynecol. 2007;46(2):135-145.
    • (2007) Taiwan J Obstet Gynecol , vol.46 , Issue.2 , pp. 135-145
    • Kuo, W.H.1
  • 15
    • 85127223296 scopus 로고    scopus 로고
    • The cell surface estrogen receptor, G Protein-coupled Receptor 30 (GPR30), is markedly down regulated during breast tumorigenesis
    • Poola I, Abraham J, Liu A, Marshalleck JJ, Dewitty RL. The cell surface estrogen receptor, G Protein-coupled Receptor 30 (GPR30), is markedly down regulated during breast tumorigenesis. Breast Cancer (Auckl). 2008;1:65-78.
    • (2008) Breast Cancer (Auckl) , vol.1 , pp. 65-78
    • Poola, I.1    Abraham, J.2    Liu, A.3    Marshalleck, J.J.4    Dewitty, R.L.5
  • 16
    • 34247191134 scopus 로고    scopus 로고
    • Hippo signaling in organ size control
    • Pan D. Hippo signaling in organ size control. Genes Dev. 2007;21(8):886-897.
    • (2007) Genes Dev , vol.21 , Issue.8 , pp. 886-897
    • Pan, D.1
  • 17
    • 77951837150 scopus 로고    scopus 로고
    • The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version
    • Zhao B, Li L, Lei Q, Guan KL. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev. 2010;24(9):862-874.
    • (2010) Genes Dev , vol.24 , Issue.9 , pp. 862-874
    • Zhao, B.1    Li, L.2    Lei, Q.3    Guan, K.L.4
  • 18
    • 84875476208 scopus 로고    scopus 로고
    • The Hippo pathway and human cancer
    • Harvey KF, Zhang X, Thomas DM. The Hippo pathway and human cancer. Nat Rev Cancer. 2013;13(4):246-257.
    • (2013) Nat Rev Cancer , vol.13 , Issue.4 , pp. 246-257
    • Harvey, K.F.1    Zhang, X.2    Thomas, D.M.3
  • 19
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao B, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007;21(21):2747-2761.
    • (2007) Genes Dev , vol.21 , Issue.21 , pp. 2747-2761
    • Zhao, B.1
  • 20
    • 34548636132 scopus 로고    scopus 로고
    • Elucidation of a universal size-control mechanism in Drosophila and mammals
    • Dong J, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell. 2007;130(6):1120-1133.
    • (2007) Cell , vol.130 , Issue.6 , pp. 1120-1133
    • Dong, J.1
  • 21
    • 41149098966 scopus 로고    scopus 로고
    • TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
    • Lei QY, et al. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol. 2008;28(7):2426-2436.
    • (2008) Mol Cell Biol , vol.28 , Issue.7 , pp. 2426-2436
    • Lei, Q.Y.1
  • 22
    • 41949138130 scopus 로고    scopus 로고
    • Tumor suppressor LATS1 is a negative regulator of oncogene YAP
    • Hao Y, Chun A, Cheung K, Rashidi B, Yang X. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem. 2008;283(9):5496-5509.
    • (2008) J Biol Chem , vol.283 , Issue.9 , pp. 5496-5509
    • Hao, Y.1    Chun, A.2    Cheung, K.3    Rashidi, B.4    Yang, X.5
  • 23
    • 73549095761 scopus 로고    scopus 로고
    • A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)
    • Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev. 2010;24(1):72-85.
    • (2010) Genes Dev , vol.24 , Issue.1 , pp. 72-85
    • Zhao, B.1    Li, L.2    Tumaneng, K.3    Wang, C.Y.4    Guan, K.L.5
  • 24
    • 78549275131 scopus 로고    scopus 로고
    • The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase
    • Liu CY, et al. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem. 2010;285(48):37159-37169.
    • (2010) J Biol Chem , vol.285 , Issue.48 , pp. 37159-37169
    • Liu, C.Y.1
  • 25
    • 84864387121 scopus 로고    scopus 로고
    • The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrC-P-dependent degradation in response to phosphatidylinositol 3-kinase inhibition
    • Huang W, et al. The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrC-P-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem. 2012;287(31):26245-26253.
    • (2012) J Biol Chem , vol.287 , Issue.31 , pp. 26245-26253
    • Huang, W.1
  • 26
    • 47549095853 scopus 로고    scopus 로고
    • TEAD mediates YAP-dependent gene induction and growth control
    • Zhao B, et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 2008;22(14):1962-1971.
    • (2008) Genes Dev , vol.22 , Issue.14 , pp. 1962-1971
    • Zhao, B.1
  • 27
    • 67649412006 scopus 로고    scopus 로고
    • TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
    • Zhang H, et al. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009;284(20):13355-13362.
    • (2009) J Biol Chem , vol.284 , Issue.20 , pp. 13355-13362
    • Zhang, H.1
  • 28
    • 79551570342 scopus 로고    scopus 로고
    • LATS2 is a tumor suppressor gene of malignant mesothelioma
    • Murakami H, et al. LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res. 2011;71(3):873-883.
    • (2011) Cancer Res , vol.71 , Issue.3 , pp. 873-883
    • Murakami, H.1
  • 29
    • 42349088170 scopus 로고    scopus 로고
    • A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells
    • Chan SW, et al. A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res. 2008;68(8):2592-2598.
    • (2008) Cancer Res , vol.68 , Issue.8 , pp. 2592-2598
    • Chan, S.W.1
  • 30
    • 81055140859 scopus 로고    scopus 로고
    • The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
    • Cordenonsi M, et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell. 2011;147(4):759-772.
    • (2011) Cell , vol.147 , Issue.4 , pp. 759-772
    • Cordenonsi, M.1
  • 31
    • 84865260845 scopus 로고    scopus 로고
    • Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
    • Yu FX, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150(4):780-791.
    • (2012) Cell , vol.150 , Issue.4 , pp. 780-791
    • Yu, F.X.1
  • 32
    • 84865455267 scopus 로고    scopus 로고
    • Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP
    • Miller E, et al. Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. Chem Biol. 2012;19(8):955-962.
    • (2012) Chem Biol , vol.19 , Issue.8 , pp. 955-962
    • Miller, E.1
  • 33
    • 0037434618 scopus 로고    scopus 로고
    • Selective estrogen-receptor modulators - Mechanisms of action and application to clinical practice
    • Riggs BL, Hartmann LC. Selective estrogen-receptor modulators - mechanisms of action and application to clinical practice. N Engl J Med. 2003;348(7):618-629.
    • (2003) N Engl J Med , vol.348 , Issue.7 , pp. 618-629
    • Riggs, B.L.1    Hartmann, L.C.2
  • 34
    • 0032569831 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998;339(22):1609-1618.
    • (1998) N Engl J Med , vol.339 , Issue.22 , pp. 1609-1618
    • Osborne, C.K.1
  • 35
    • 12344307170 scopus 로고    scopus 로고
    • Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    • Thomas P, Pang Y, Filardo EJ, Dong J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology. 2005;146(2):624-632.
    • (2005) Endocrinology , vol.146 , Issue.2 , pp. 624-632
    • Thomas, P.1    Pang, Y.2    Filardo, E.J.3    Dong, J.4
  • 36
    • 33646366423 scopus 로고    scopus 로고
    • Virtual and biomolecular screening converge on a selective agonist for GPR30
    • Bologa CG, et al. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol. 2006;2(4):207-212.
    • (2006) Nat Chem Biol , vol.2 , Issue.4 , pp. 207-212
    • Bologa, C.G.1
  • 37
    • 67349140294 scopus 로고    scopus 로고
    • In vivo effects of a GPR30 antagonist
    • Dennis MK, et al. In vivo effects of a GPR30 antagonist. Nat Chem Biol. 2009;5(6):421-427.
    • (2009) Nat Chem Biol , vol.5 , Issue.6 , pp. 421-427
    • Dennis, M.K.1
  • 38
    • 78650845707 scopus 로고    scopus 로고
    • G protein-coupled receptors: Novel targets for drug discovery in cancer
    • Lappano R, Maggiolini M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat Rev Drug Discov. 2011;10(1):47-60.
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.1 , pp. 47-60
    • Lappano, R.1    Maggiolini, M.2
  • 39
    • 84875264155 scopus 로고    scopus 로고
    • Vasoconstriction induced by G1, a G-protein-coupled oestrogen receptor1 (GPER-1) agonist, in the isolated perfused rat kidney
    • Kurt AH, Buyukafsar K. Vasoconstriction induced by G1, a G-protein-coupled oestrogen receptor1 (GPER-1) agonist, in the isolated perfused rat kidney. Eur J Pharmacol. 2013;702(1):71-78.
    • (2013) Eur J Pharmacol , vol.702 , Issue.1 , pp. 71-78
    • Kurt, A.H.1    Buyukafsar, K.2
  • 40
    • 84855326431 scopus 로고    scopus 로고
    • Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
    • Zhao B, Li L, Wang L, Wang CY, Yu J, Guan KL. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev. 2012;26(1):54-68.
    • (2012) Genes Dev , vol.26 , Issue.1 , pp. 54-68
    • Zhao, B.1    Li, L.2    Wang, L.3    Wang, C.Y.4    Yu, J.5    Guan, K.L.6
  • 41
    • 79958284636 scopus 로고    scopus 로고
    • Role of YAP/TAZ in mechanotransduction
    • Dupont S, et al. Role of YAP/TAZ in mechanotransduction. Nature. 2011;474(7350):179-183.
    • (2011) Nature , vol.474 , Issue.7350 , pp. 179-183
    • Dupont, S.1
  • 42
    • 0036931306 scopus 로고    scopus 로고
    • Lysophosphatidic acid induces focal adhesion assembly through Rho/Rho-associated kinase pathway in human ovarian cancer cells
    • Sawada K, et al. Lysophosphatidic acid induces focal adhesion assembly through Rho/Rho-associated kinase pathway in human ovarian cancer cells. Gynecol Oncol. 2002;87(3):252-259.
    • (2002) Gynecol Oncol , vol.87 , Issue.3 , pp. 252-259
    • Sawada, K.1
  • 43
    • 78649680349 scopus 로고    scopus 로고
    • Thrombin promotes actin stress fiber formation in RPE through Rho/ROCK-mediated MLC phosphorylation
    • Ruiz-Loredo AY, Lopez E, Lopez-Colome AM. Thrombin promotes actin stress fiber formation in RPE through Rho/ROCK-mediated MLC phosphorylation. J Cell Physiol. 2011;226(2):414-423.
    • (2011) J Cell Physiol , vol.226 , Issue.2 , pp. 414-423
    • Ruiz-Loredo, A.Y.1    Lopez, E.2    Lopez-Colome, A.M.3
  • 45
    • 0037044808 scopus 로고    scopus 로고
    • Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation
    • Glantschnig H, Rodan GA, Reszka AA. Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation. J Biol Chem. 2002;277(45):42987-42996.
    • (2002) J Biol Chem , vol.277 , Issue.45 , pp. 42987-42996
    • Glantschnig, H.1    Rodan, G.A.2    Reszka, A.A.3
  • 46
    • 0036550954 scopus 로고    scopus 로고
    • The estrogen-regulated protein, TFF1, stimulates migration of human breast cancer cells
    • Prest SJ, May FE, Westley BR. The estrogen-regulated protein, TFF1, stimulates migration of human breast cancer cells. FASEB J. 2002;16(6):592-594.
    • (2002) FASEB J , vol.16 , Issue.6 , pp. 592-594
    • Prest, S.J.1    May, F.E.2    Westley, B.R.3
  • 47
    • 33644638521 scopus 로고    scopus 로고
    • Estrogen receptors and human disease
    • Deroo BJ, Korach KS. Estrogen receptors and human disease. J Clin Invest. 2006;116(3):561-570.
    • (2006) J Clin Invest , vol.116 , Issue.3 , pp. 561-570
    • Deroo, B.J.1    Korach, K.S.2
  • 48
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy hormonal therapy for early breast cancer on recurrence 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy hormonal therapy for early breast cancer on recurrence 15-year survival: an overview of the randomised trials. Lancet. 2005;365(9472):1687-1717.
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 49
    • 77955771545 scopus 로고    scopus 로고
    • Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells
    • Ignatov A, Ignatov T, Roessner A, Costa SD, Kalinski T. Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells. Breast Cancer Res Treat. 2010;123(1):87-96.
    • (2010) Breast Cancer Res Treat , vol.123 , Issue.1 , pp. 87-96
    • Ignatov, A.1    Ignatov, T.2    Roessner, A.3    Costa, S.D.4    Kalinski, T.5
  • 50
    • 33646342738 scopus 로고    scopus 로고
    • NKX3.1 stabilizes p53, inhibits AKT activation, blocks prostate cancer initiation caused by PTEN loss
    • Lei Q, et al. NKX3.1 stabilizes p53, inhibits AKT activation, blocks prostate cancer initiation caused by PTEN loss. Cancer Cell. 2006;9(5):367-378.
    • (2006) Cancer Cell , vol.9 , Issue.5 , pp. 367-378
    • Lei, Q.1


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