Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 18, 2015, Pages 5714-5719

  Liin, Sara I ^a,b   Ejneby, Malin Silverå ^b   Barro Soria, Rene ^a   Skarsfeldt, Mark Alexander ^c   Larsson, Johan E ^a,b   Härlin, Frida Starck ^a,b   Parkkari, Teija ^d   Bentzen, Bo Hjorth ^c   Schmitt, Nicole ^c   Larsson, H Peter ^a   Elinder, Fredrik ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b LINKÖPING UNIVERSITY   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Antiarrhythmic; IKs; KCNE1; KCNQ1; Kv7.1

Indexed keywords

DOCOSAHEXAENOIC ACID; FATTY ACID DERIVATIVE; I KS CHANNEL; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID DERIVATIVE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG; ANTIARRHYTHMIC AGENT; UNSATURATED FATTY ACID;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; GUINEA PIG; HEART; HEART MUSCLE CELL; HEART MUSCLE EXCITABILITY; ISOLATED HEART; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON TRANSPORT; SENSITIVITY ANALYSIS; STATIC ELECTRICITY; ANIMAL; ARRHYTHMIAS, CARDIAC; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ELECTRIC CONDUCTIVITY; FEMALE; GENETICS; HUMAN; METABOLISM; MUTATION; OOCYTE; PERFUSION; PROTEIN TERTIARY STRUCTURE; RAT; SCANNING ELECTRON MICROSCOPY; SPRAGUE DAWLEY RAT; XENOPUS LAEVIS;

CAVIA; RATTUS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; ELECTRIC CONDUCTIVITY; FATTY ACIDS, UNSATURATED; FEMALE; GUINEA PIGS; HEART; HUMANS; KCNQ1 POTASSIUM CHANNEL; MICROSCOPY, ELECTRON, SCANNING; MUTATION; MYOCYTES, CARDIAC; OOCYTES; PERFUSION; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; STATIC ELECTRICITY; XENOPUS LAEVIS;

EID: 84928978583     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1503488112     Document Type: Article

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