메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN B2; EPHRIN RECEPTOR A4; PARVALBUMIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SOX2;

EID: 84928975654     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8017     Document Type: Article
Times cited : (23)

References (50)
  • 1
    • 0032933174 scopus 로고    scopus 로고
    • P27(Kip1) links cell proliferation to morphogenesis in the developing organ of corti
    • Chen, P. & Segil, N. p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti. Development 126, 1581-1590 (1999).
    • (1999) Development , vol.126 , pp. 1581-1590
    • Chen, P.1    Segil, N.2
  • 2
    • 13844309351 scopus 로고    scopus 로고
    • Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein
    • Sage, C. et al. Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science 307, 1114-1118 (2005).
    • (2005) Science , vol.307 , pp. 1114-1118
    • Sage, C.1
  • 3
    • 33750290919 scopus 로고    scopus 로고
    • Regulation of cell fate in the sensory epithelia of the inner ear
    • Kelley, M. W. Regulation of cell fate in the sensory epithelia of the inner ear. Nat. Rev. Neurosci. 7, 837-849 (2006).
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 837-849
    • Kelley, M.W.1
  • 5
    • 0032427792 scopus 로고    scopus 로고
    • Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: Parallels with Drosophila sense-organ development
    • Adam, J. et al. Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development. Development 125, 4645-4654 (1998).
    • (1998) Development , vol.125 , pp. 4645-4654
    • Adam, J.1
  • 6
    • 0033021954 scopus 로고    scopus 로고
    • Notch signalling pathway mediates hair cell development in mammalian cochlea
    • Lanford, P. J. et al. Notch signalling pathway mediates hair cell development in mammalian cochlea. Nature Genet. 21, 289-292 (1999).
    • (1999) Nature Genet. , vol.21 , pp. 289-292
    • Lanford, P.J.1
  • 7
    • 14044258714 scopus 로고    scopus 로고
    • Two contrasting roles for Notch activity in chick inner ear development: Specification of prosensory patches and lateral inhibition of hair-cell differentiation
    • Daudet, N. & Lewis, J. Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation. Development 132, 541-551 (2005).
    • (2005) Development , vol.132 , pp. 541-551
    • Daudet, N.1    Lewis, J.2
  • 8
    • 84872173335 scopus 로고    scopus 로고
    • Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma
    • Mizutari, K. et al. Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma. Neuron 77, 58-69 (2013).
    • (2013) Neuron , vol.77 , pp. 58-69
    • Mizutari, K.1
  • 9
    • 15844429889 scopus 로고    scopus 로고
    • Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis
    • Gale, N. W. et al. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron 17, 9-19 (1996).
    • (1996) Neuron , vol.17 , pp. 9-19
    • Gale, N.W.1
  • 10
    • 0031213749 scopus 로고    scopus 로고
    • The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells
    • Smith, A., Robinson, V., Patel, K. & Wilkinson, D. G. The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells. Curr. Biol. 7, 561-570 (1997).
    • (1997) Curr. Biol. , vol.7 , pp. 561-570
    • Smith, A.1    Robinson, V.2    Patel, K.3    Wilkinson, D.G.4
  • 11
    • 0032190648 scopus 로고    scopus 로고
    • Eph signaling is required for segmentation and differentiation of the somites
    • Durbin, L. et al. Eph signaling is required for segmentation and differentiation of the somites. Genes Dev. 12, 3096-3109 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 3096-3109
    • Durbin, L.1
  • 12
    • 0033168047 scopus 로고    scopus 로고
    • Eph receptors and ephrins restrict cell intermingling and communication
    • Mellitzer, G., Xu, Q. & Wilkinson, D. G. Eph receptors and ephrins restrict cell intermingling and communication. Nature 400, 77-81 (1999).
    • (1999) Nature , vol.400 , pp. 77-81
    • Mellitzer, G.1    Xu, Q.2    Wilkinson, D.G.3
  • 13
    • 0033587129 scopus 로고    scopus 로고
    • In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins
    • Xu, Q., Mellitzer, G., Robinson, V. & Wilkinson, D. G. In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature 399, 267-271 (1999).
    • (1999) Nature , vol.399 , pp. 267-271
    • Xu, Q.1    Mellitzer, G.2    Robinson, V.3    Wilkinson, D.G.4
  • 14
    • 60849104389 scopus 로고    scopus 로고
    • EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel
    • Kemp, H. A., Cooke, J. E. & Moens, C. B. EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel. Dev. Biol. 327, 313-326 (2009).
    • (2009) Dev. Biol. , vol.327 , pp. 313-326
    • Kemp, H.A.1    Cooke, J.E.2    Moens, C.B.3
  • 15
    • 0036568637 scopus 로고    scopus 로고
    • Boundary formation in the hindbrain: Eph only it were simple
    • Cooke, J. E. & Moens, C. B. Boundary formation in the hindbrain: Eph only it were simple. Trends Neurosci. 25, 260-267 (2002).
    • (2002) Trends Neurosci , vol.25 , pp. 260-267
    • Cooke, J.E.1    Moens, C.B.2
  • 16
    • 78650360161 scopus 로고    scopus 로고
    • Boundary formation and maintenance in tissue development
    • Dahmann, C., Oates, A. C. & Brand, M. Boundary formation and maintenance in tissue development. Nat. Rev. Genet. 12, 43-55 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 43-55
    • Dahmann, C.1    Oates, A.C.2    Brand, M.3
  • 17
    • 84896406581 scopus 로고    scopus 로고
    • Boundary formation in the development of the vertebrate hindbrain
    • Xu, Q. & Wilkinson, D. G. Boundary formation in the development of the vertebrate hindbrain. WIREs Dev. Biol 2, 735-745 (2013).
    • (2013) WIREs Dev. Biol , vol.2 , pp. 735-745
    • Xu, Q.1    Wilkinson, D.G.2
  • 18
    • 33947098414 scopus 로고    scopus 로고
    • Ephrin-B2 forward signalling regulates somite patterning and neural crest cell development
    • Davy, A. & Soriano, P. Ephrin-B2 forward signalling regulates somite patterning and neural crest cell development. Dev. Biol. 304, 182-193 (2007).
    • (2007) Dev. Biol. , vol.304 , pp. 182-193
    • Davy, A.1    Soriano, P.2
  • 19
    • 57449114544 scopus 로고    scopus 로고
    • Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea
    • Dabdoub, A. et al. Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc. Natl Acad. Sci. USA 105, 18396-18401 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 18396-18401
    • Dabdoub, A.1
  • 20
    • 0031944815 scopus 로고    scopus 로고
    • Distribution of Eph-related molecules in the developing and mature cochlea
    • Bianchi, L. M. & Gale, N. W. Distribution of Eph-related molecules in the developing and mature cochlea. Hear. Res. 117, 161-172 (1998).
    • (1998) Hear. Res. , vol.117 , pp. 161-172
    • Bianchi, L.M.1    Gale, N.W.2
  • 21
    • 0032947608 scopus 로고    scopus 로고
    • Comparison of ephrin-A ligand and EphA receptor distribution in the developing inner ear
    • Bianchi, L. M. & Liu, H. Comparison of ephrin-A ligand and EphA receptor distribution in the developing inner ear. Anat. Rec. 254, 127-134 (1999).
    • (1999) Anat. Rec. , vol.254 , pp. 127-134
    • Bianchi, L.M.1    Liu, H.2
  • 22
    • 80053190880 scopus 로고    scopus 로고
    • Structure and development of cochlear afferent innervation in mammals
    • Defourny, J., Lallemend, F. & Malgrange, B. Structure and development of cochlear afferent innervation in mammals. Am. J. Physiol. Cell Physiol 301, C750-C761 (2011).
    • (2011) Am. J. Physiol. Cell Physiol , vol.301 , pp. C750-C761
    • Defourny, J.1    Lallemend, F.2    Malgrange, B.3
  • 23
    • 37349127787 scopus 로고    scopus 로고
    • Auditory brainstem responses are impaired in EphA4 and ephrin-B2 deficient mice
    • Miko, I. J., Henkemeyer, M. & Cramer, K. S. Auditory brainstem responses are impaired in EphA4 and ephrin-B2 deficient mice. Hear. Res. 235, 39-46 (2008).
    • (2008) Hear. Res. , vol.235 , pp. 39-46
    • Miko, I.J.1    Henkemeyer, M.2    Cramer, K.S.3
  • 24
    • 0036293742 scopus 로고    scopus 로고
    • Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation
    • Bajenaru, M. L. et al. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol. Cell. Biol. 22, 5100-5113 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5100-5113
    • Bajenaru, M.L.1
  • 25
    • 0346732915 scopus 로고    scopus 로고
    • Hippocampal plasticity requires postsynaptic ephrinBs
    • Grunwald, I. C. et al. Hippocampal plasticity requires postsynaptic ephrinBs. Nat. Neurosci. 7, 33-40 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 33-40
    • Grunwald, I.C.1
  • 26
    • 0037039171 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein expression and promoter activity in the inner ear of developing and adult mice
    • Rio, C., Dikkes, P., Liberman, M. C. & Corfas, G. Glial fibrillary acidic protein expression and promoter activity in the inner ear of developing and adult mice. J. Comp. Neurol. 442, 156-162 (2002).
    • (2002) J. Comp. Neurol , vol.442 , pp. 156-162
    • Rio, C.1    Dikkes, P.2    Liberman, M.C.3    Corfas, G.4
  • 27
    • 79951677325 scopus 로고    scopus 로고
    • Expression of candidate markers for stem/progenitor cells in the inner ears of developing and adult GFAP and nestin promoter-GFP transgenic mice
    • Smeti, I. et al. Expression of candidate markers for stem/progenitor cells in the inner ears of developing and adult GFAP and nestin promoter-GFP transgenic mice. Gene Expr. Patterns 11, 22-32 (2011).
    • (2011) Gene Expr. Patterns , vol.11 , pp. 22-32
    • Smeti, I.1
  • 28
    • 1342344617 scopus 로고    scopus 로고
    • Expression of alpha and beta parvalbumin is differentially regulated in the rat organ of corti during development
    • Yang, D., Thalmann, I., Thalmann, R. & Simmons, D. D. Expression of alpha and beta parvalbumin is differentially regulated in the rat organ of corti during development. J. Neurobiol. 58, 479-492 (2004).
    • (2004) J. Neurobiol. , vol.58 , pp. 479-492
    • Yang, D.1    Thalmann, I.2    Thalmann, R.3    Simmons, D.D.4
  • 29
    • 84863011620 scopus 로고    scopus 로고
    • Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2
    • Ahmed, M. et al. Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. Dev. Cell 22, 377-390 (2012).
    • (2012) Dev. Cell , vol.22 , pp. 377-390
    • Ahmed, M.1
  • 30
    • 0042442460 scopus 로고    scopus 로고
    • Control of skeletal patterning by ephrinB1-EphB interactions
    • Compagni, A., Logan, M., Klein, R. & Adams, R. H. Control of skeletal patterning by ephrinB1-EphB interactions. Dev. Cell 5, 217-230 (2003).
    • (2003) Dev. Cell , vol.5 , pp. 217-230
    • Compagni, A.1    Logan, M.2    Klein, R.3    Adams, R.H.4
  • 31
    • 2942560339 scopus 로고    scopus 로고
    • Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome
    • Twigg, S. R. et al. Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome. Proc. Natl Acad. Sci. USA 101, 8652-8657 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 8652-8657
    • Twigg, S.R.1
  • 32
    • 33750240193 scopus 로고    scopus 로고
    • Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome
    • Davy, A., Bush, J. O. & Soriano, P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 4, e315 (2006).
    • (2006) PLoS Biol , vol.4 , pp. e315
    • Davy, A.1    Bush, J.O.2    Soriano, P.3
  • 33
    • 20344396123 scopus 로고    scopus 로고
    • Eph receptor signalling casts a wide net on cell behaviour
    • Pasquale, E. B. Eph receptor signalling casts a wide net on cell behaviour. Nat. Rev. Mol. Cell Biol. 6, 462-475 (2005).
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 462-475
    • Pasquale, E.B.1
  • 34
    • 59349089711 scopus 로고    scopus 로고
    • Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin
    • Creppe, C. et al. Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell 136, 551-564 (2009).
    • (2009) Cell , vol.136 , pp. 551-564
    • Creppe, C.1
  • 35
    • 0028787263 scopus 로고
    • Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B. Proc
    • Hasson, T., Heintzelman, M. B., Santos-Sacchi, J., Corey, D. P. & Mooseker, M. S. Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B. Proc. Natl Acad. Sci. USA 92, 9815-9819 (1995).
    • (1995) Natl Acad. Sci. USA , vol.92 , pp. 9815-9819
    • Hasson, T.1    Heintzelman, M.B.2    Santos-Sacchi, J.3    Corey, D.P.4    Mooseker, M.S.5
  • 36
    • 33745577647 scopus 로고    scopus 로고
    • Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
    • White, P. M., Doetzlhofer, A., Lee, Y. S., Groves, A. K. & Segil, N. Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells. Nature 441, 984-987 (2006).
    • (2006) Nature , vol.441 , pp. 984-987
    • White, P.M.1    Doetzlhofer, A.2    Lee, Y.S.3    Groves, A.K.4    Segil, N.5
  • 37
    • 33846917180 scopus 로고    scopus 로고
    • Distinct population of hair cell progenitors can be isolated from the postnatal mouse cochlea using side population analysis
    • Savary, E. et al. Distinct population of hair cell progenitors can be isolated from the postnatal mouse cochlea using side population analysis. Stem Cells 25, 332-339 (2007).
    • (2007) Stem Cells , vol.25 , pp. 332-339
    • Savary, E.1
  • 38
    • 73649128536 scopus 로고    scopus 로고
    • Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity
    • Qin, H. et al. Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. J. Biol. Chem. 285, 644-654 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 644-654
    • Qin, H.1
  • 39
    • 74749100702 scopus 로고    scopus 로고
    • Sox2 is required for maintenance and regeneration, but not initial development, of hair cells in the zebrafish inner ear
    • Millimaki, B. B., Sweet, E. M. & Riley, B. B. Sox2 is required for maintenance and regeneration, but not initial development, of hair cells in the zebrafish inner ear. Dev. Biol. 338, 262-269 (2010).
    • (2010) Dev. Biol. , vol.338 , pp. 262-269
    • Millimaki, B.B.1    Sweet, E.M.2    Riley, B.B.3
  • 40
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams, R. H. & Alitalo, K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8, 464-478 (2007).
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 41
    • 63649138023 scopus 로고    scopus 로고
    • Arterial-venous specification during development
    • Swift, M. R. & Weinstein, B. M. Arterial-venous specification during development. Circ. Res. 104, 576-588 (2009).
    • (2009) Circ. Res , vol.104 , pp. 576-588
    • Swift, M.R.1    Weinstein, B.M.2
  • 42
    • 1842531221 scopus 로고    scopus 로고
    • Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain
    • Cheng, Y. C. et al. Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. Dev. Cell 6, 539-550 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 539-550
    • Cheng, Y.C.1
  • 43
    • 80051499185 scopus 로고    scopus 로고
    • Notch signalling stabilises boundary formation at the midbrain-hindbrain organiser
    • Tossell, K., Kiecker, C., Wizenmann, A., Lang, E. & Irving, C. Notch signalling stabilises boundary formation at the midbrain-hindbrain organiser. Development 138, 3745-3757 (2011).
    • (2011) Development , vol.138 , pp. 3745-3757
    • Tossell, K.1    Kiecker, C.2    Wizenmann, A.3    Lang, E.4    Irving, C.5
  • 44
    • 0038118296 scopus 로고    scopus 로고
    • Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo
    • Kawamoto, K., Ishimoto, S., Minoda, R., Brough, D. E. & Raphael, Y. Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. J. Neurosci. 23, 4395-4400 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 4395-4400
    • Kawamoto, K.1    Ishimoto, S.2    Minoda, R.3    Brough, D.E.4    Raphael, Y.5
  • 45
    • 84860657802 scopus 로고    scopus 로고
    • Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo
    • Kelly, M. C., Chang, Q., Pan, A., Lin, X. & Chen, P. Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo. J. Neurosci. 32, 6699-6710 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 6699-6710
    • Kelly, M.C.1    Chang, Q.2    Pan, A.3    Lin, X.4    Chen, P.5
  • 46
    • 0034127584 scopus 로고    scopus 로고
    • Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears
    • Zheng, J. L. & Gao, W. Q. Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat. Neurosci. 3, 580-586 (2000).
    • (2000) Nat. Neurosci. , vol.3 , pp. 580-586
    • Zheng, J.L.1    Gao, W.Q.2
  • 47
    • 0027095691 scopus 로고
    • A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm
    • Nieto, M. A., Gilardi-Hebenstreit, P., Charnay, P. & Wilkinson, D. G. A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development 116, 1137-1150 (1992).
    • (1992) Development , vol.116 , pp. 1137-1150
    • Nieto, M.A.1    Gilardi-Hebenstreit, P.2    Charnay, P.3    Wilkinson, D.G.4
  • 48
    • 0028093017 scopus 로고
    • Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain
    • Becker, N. et al. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech. Dev. 47, 3-17 (1994).
    • (1994) Mech. Dev. , vol.47 , pp. 3-17
    • Becker, N.1
  • 49
    • 84874606762 scopus 로고    scopus 로고
    • Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells
    • Defourny, J. et al. Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells. Nat. Commun 4, 1438 (2013).
    • (2013) Nat. Commun , vol.4 , pp. 1438
    • Defourny, J.1
  • 50
    • 66149133341 scopus 로고    scopus 로고
    • Angiotensinogen delays angiogenesis and tumor growth of hepatocarcinoma in transgenic mice
    • Vincent, F. et al. Angiotensinogen delays angiogenesis and tumor growth of hepatocarcinoma in transgenic mice. Cancer Res. 69, 2853-2860 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 2853-2860
    • Vincent, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.