Hippocampal plasticity requires postsynaptic ephrinBs

Nature Neuroscience

Volumn 7, Issue 1, 2004, Pages 33-40

  Grunwald, Ilona C ^a   Korte, Martin ^a   Adelmann, Giselind ^b   Plueck, Anne ^c   Kullander, Klas ^d   Adams, Ralf H ^e   Frotscher, Michael ^b   Bonhoeffer, Tobias ^a   Klein, Rüdiger ^a  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN; EPHRIN A4; EPHRIN B; EPHRIN B RECEPTOR TYROSINE KINASE; LIGAND; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ULTRASTRUCTURE; CELLULAR DISTRIBUTION; HIPPOCAMPUS; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTIC TRANSMISSION;

ANIMALS; CELLS, CULTURED; EPHRIN-B1; EPHRIN-B2; EPHRIN-B3; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; MICE; MICE, TRANSGENIC; NEURONAL PLASTICITY; RECEPTORS, EPH FAMILY; SYNAPSES;

EID: 0346732915     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1164     Document Type: Article

References (38)

1. Henderson, J.T. et al. The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron 32, 1041-1056 (2001).
2. Grunwald, I.C. et al. Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron 32, 1027-1040 (2001).
3. Contractor, A. et al. Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP. Science 296, 1864-1869 (2002).
4. Wilkinson, D.G. Multiple roles of EPH receptors and ephrins in neural development. Nat. Rev. Neurosci. 2, 155-164 (2001).
5. Palmer, A. & Klein, R. Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function. Genes Dev. 17, 1429-1450 (2003).
6. Dalva, M.B. et al. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell 103, 945-956 (2000).
7. Takasu, M.A., Dalva, M.B., Zigmond, R.E. & Greenberg, M.E. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science 295, 491-495 (2002).
8. Kullander, K. & Klein, R. Mechanisms and functions of Eph and ephrin signalling. Nat. Rev. Mol. Cell. Biol. 3, 475-486 (2002).
9. Cho, K.O., Hunt, C.A. & Kennedy, M.B. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9, 929-942 (1992).
10. Walikonis, R.S. et al. Identification of proteins in the postsynaptic density fraction by mass spectrometry. J. Neurosci. 20, 4069-4080 (2000).
11. Chen, L. et al. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408, 936-943 (2000).
12. Dong, H., Zhang, P., Liao, D. & Huganir, R.L. Characterization, expression, and distribution of GRIP protein. Ann. NY Acad. Sci. 868, 535-540 (1999).
13. Wyszynski, M. et al. Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo. J. Neurosci. 19, 6528-6537 (1999).
14. Buchert, M. et al. The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain. J. Cell Biol. 144, 361-371 (1999).
15. Wang, H.U., Chen, Z.F. & Anderson, D.J. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93, 741-753 (1998).
16. Adams, R.H. et al. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 13, 295-306 (1999).
17. Minichiello, L. et al. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24, 401-414 (1999).
18. Ethell, I.M. et al. EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron 31, 1001-1013 (2001).
19. Murai, K.K., Nguyen, L.N., Irie, F., Yamaguchi, Y. & Pasquale, E.B. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat. Neurosci. 6, 153-160 (2003).
20. Penzes, P. et al. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron 37, 263-274 (2003).
21. Henkemeyer, M., Itkis, O.S., Ngo, M., Hickmott, P.W. & Ethell, E.M. Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J. Cell Biol. (in press).
22. Bliss, T.V. & Collingridge, G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39 (1993).
23. Kullander, K. et al. Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev. 15, 877-888 (2001).
24. Yokoyama, N. et al. Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron 29, 85-97 (2001).
25. Dudek, S.M. & Bear, M.F. Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. Proc. Natl. Acad. Sci. USA 89, 4363-4367 (1992).
26. Mulkey, R.M. & Malenka, R.C. Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus. Neuron 9, 967-975 (1992).
27. Tronche, F. et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 23, 99-103 (1999).
28. Mellitzer, G., Xu, Q. & Wilkinson, D.G. Eph receptors and ephrins restrict cell intermingling and communication. Nature 400, 77-81 (1999).
29. Kullander, K. et al. Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo. Neuron 29, 73-84 (2001).
30. Dottori, M. et al. EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc. Natl. Acad. Sci. USA 95, 13248-13253 (1998).
31. Kullander, K. et al. Role of EphA4 and EphrinB3 in local neuronal circuits that control walking. Science 299, 1889-1892 (2003).
32. Ghosh, A. Neurobiology. Learning more about NMDA receptor regulation. Science 295, 449-451 (2002).
33. Murai, K.K. & Pasquale, E.B. Can Eph receptors stimulate the mind? Neuron 33, 159-162 (2002).
34. Henkemeyer, M. et al. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell 86, 35-46 (1996).
35. Godenschwege, T.A., Hu, H., Shan-Crofts, X., Goodman, C.S. & Murphey, R.K. Bidirectional signaling by Semaphorin la during central synapse formation in Drosophila. Nat. Neurosci. 5, 1294-1301 (2002).
36. Zimmer, M., Palmer, A., Kohler, J. & Klein, R. EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat. Cell Biol. 5, 869-878 (2003).
37. Marston, D.J., Dickinson, S. & Nobes, C.D. Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion. Nat. Cell Biol. 5, 879-888 (2003).
38. Dymecki, S.M. A modular set of Flp, FRT and lacZ fusion vectors for manipulating genes by site-specific recombination. Gene 171, 197-201 (1996).