메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

Manipulation of B-cell responses with histone deacetylase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; PANOBINOSTAT; ROMIDEPSIN; VORINOSTAT; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; INDOLE DERIVATIVE;

EID: 84928974764     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7838     Document Type: Article
Times cited : (74)

References (61)
  • 1
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations
    • Jacob, J., Kassir, R. & Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173, 1165-1175 (1991).
    • (1991) J. Exp. Med , vol.173 , pp. 1165-1175
    • Jacob, J.1    Kassir, R.2    Kelsoe, G.3
  • 2
    • 0025951891 scopus 로고
    • Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens
    • Liu, Y. J., Zhang, J., Lane, P. J., Chan, E. Y. & MacLennan, I. C. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21, 2951-2962 (1991).
    • (1991) Eur. J. Immunol , vol.21 , pp. 2951-2962
    • Liu, Y.J.1    Zhang, J.2    Lane, P.J.3    Chan, E.Y.4    Maclennan, I.C.5
  • 3
    • 23844445862 scopus 로고    scopus 로고
    • Two waves of memory B-cell generation in the primary immune response
    • Inamine, A. et al. Two waves of memory B-cell generation in the primary immune response. Int. Immunol. 17, 581-589 (2005).
    • (2005) Int. Immunol , vol.17 , pp. 581-589
    • Inamine, A.1
  • 4
    • 0022975140 scopus 로고
    • Distinct short-lived and long-lived antibody-producing cell populations
    • Ho, F., Lortan, J. E., MacLennan, I. C. & Khan, M. Distinct short-lived and long-lived antibody-producing cell populations. Eur. J. Immunol. 16, 1297-1301 (1986).
    • (1986) Eur. J. Immunol , vol.16 , pp. 1297-1301
    • Ho, F.1    Lortan, J.E.2    Maclennan, I.C.3    Khan, M.4
  • 5
    • 0021679848 scopus 로고
    • Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
    • Tsujimoto, Y., Finger, L. R., Yunis, J., Nowell, P. C. & Croce, C. M. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226, 1097-1099 (1984).
    • (1984) Science , vol.226 , pp. 1097-1099
    • Tsujimoto, Y.1    Finger, L.R.2    Yunis, J.3    Nowell, P.C.4    Croce, C.M.5
  • 6
    • 0000538165 scopus 로고
    • Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells
    • Dalla-Favera, R. et al. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc. Natl Acad. Sci. USA 79, 7824-7827 (1982).
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 7824-7827
    • Dalla-Favera, R.1
  • 7
    • 0001292985 scopus 로고
    • Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
    • Taub, R. et al. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc. Natl Acad. Sci. USA 79, 7837-7841 (1982).
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 7837-7841
    • Taub, R.1
  • 8
    • 0027495491 scopus 로고
    • Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
    • Ye, B. H. et al. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 262, 747-750 (1993).
    • (1993) Science , vol.262 , pp. 747-750
    • Ye, B.H.1
  • 9
    • 0029086993 scopus 로고
    • Self-tolerance checkpoints in B lymphocyte development
    • Goodnow, C. C. et al. Self-tolerance checkpoints in B lymphocyte development. Adv. Immunol. 59, 279-368 (1995).
    • (1995) Adv. Immunol , vol.59 , pp. 279-368
    • Goodnow, C.C.1
  • 10
    • 25444476976 scopus 로고    scopus 로고
    • B cell abnormality and autoimmune disorders
    • Tsubata, T. B cell abnormality and autoimmune disorders. Autoimmunity 38, 331-337 (2005).
    • (2005) Autoimmunity , vol.38 , pp. 331-337
    • Tsubata, T.1
  • 12
    • 79958254628 scopus 로고    scopus 로고
    • Epigenetic control of lymphocyte differentiation
    • Lopez-Granados, E. Epigenetic control of lymphocyte differentiation. Adv. Exp. Med. Biol. 711, 26-35 (2011).
    • (2011) Adv. Exp. Med. Biol , vol.711 , pp. 26-35
    • Lopez-Granados, E.1
  • 13
    • 58849092225 scopus 로고    scopus 로고
    • Epigenetic control of T-helper-cell differentiation
    • Wilson, C. B., Rowell, E. & Sekimata, M. Epigenetic control of T-helper-cell differentiation. Nat. Rev. Immunol. 9, 91-105 (2009).
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 91-105
    • Wilson, C.B.1    Rowell, E.2    Sekimata, M.3
  • 14
    • 18444414332 scopus 로고    scopus 로고
    • Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
    • Lagger, G. et al. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 21, 2672-2681 (2002).
    • (2002) EMBO J. , vol.21 , pp. 2672-2681
    • Lagger, G.1
  • 15
    • 77955425859 scopus 로고    scopus 로고
    • Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis
    • Wilting, R. H. et al. Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. EMBO J. 29, 2586-2597 (2010).
    • (2010) EMBO J. , vol.29 , pp. 2586-2597
    • Wilting, R.H.1
  • 16
    • 77649115437 scopus 로고    scopus 로고
    • Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression
    • Yamaguchi, T. et al. Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev. 24, 455-469 (2010).
    • (2010) Genes Dev , vol.24 , pp. 455-469
    • Yamaguchi, T.1
  • 17
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • Bolden, J. E., Peart, M. J. & Johnstone, R. W. Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discov. 5, 769-784 (2006).
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 18
    • 78651352243 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Potential targets responsible for their anti-cancer effect
    • Dickinson, M., Johnstone, R. W. & Prince, H. M. Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect. Invest. New Drugs 28(Suppl 1): S3-S20 (2010).
    • (2010) Invest. New Drugs , vol.28 , pp. S3-S20
    • Dickinson, M.1    Johnstone, R.W.2    Prince, H.M.3
  • 19
    • 84864040412 scopus 로고    scopus 로고
    • Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy
    • Chesi, M. et al. Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy. Blood 120, 376-385 (2012).
    • (2012) Blood , vol.120 , pp. 376-385
    • Chesi, M.1
  • 20
    • 34249941680 scopus 로고    scopus 로고
    • Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma
    • Lindemann, R. K. et al. Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc. Natl Acad. Sci. USA 104, 8071-8076 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 8071-8076
    • Lindemann, R.K.1
  • 21
    • 3042566927 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses
    • Moreira, J. M., Scheipers, P. & Sorensen, P. The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses. BMC Cancer 3, 30 (2003).
    • (2003) BMC Cancer , vol.3 , pp. 30
    • Moreira, J.M.1    Scheipers, P.2    Sorensen, P.3
  • 22
    • 84891276397 scopus 로고    scopus 로고
    • An intact immune system is required for the anti-cancer activities of histone deacetylase inhibitors
    • West, A. C. et al. An intact immune system is required for the anti-cancer activities of histone deacetylase inhibitors. Cancer Res. 73, 7265-7276 (2013).
    • (2013) Cancer Res , vol.73 , pp. 7265-7276
    • West, A.C.1
  • 23
    • 35948980739 scopus 로고    scopus 로고
    • Deacetylase inhibition promotes the generation and function of regulatory T cells
    • Tao, R. et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13, 1299-1307 (2007).
    • (2007) Nat. Med , vol.13 , pp. 1299-1307
    • Tao, R.1
  • 24
    • 15444377542 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription
    • Lu, Z. P., Ju, Z. L., Shi, G. Y., Zhang, J. W. & Sun, J. Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription. Biochem. Biophys. Res. Commun. 330, 204-209 (2005).
    • (2005) Biochem. Biophys. Res. Commun , vol.330 , pp. 204-209
    • Lu, Z.P.1    Ju, Z.L.2    Shi, G.Y.3    Zhang, J.W.4    Sun, J.5
  • 25
    • 0037330279 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse
    • Mishra, N., Reilly, C. M., Brown, D. R., Ruiz, P. & Gilkeson, G. S. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. J. Clin. Invest. 111, 539-552 (2003).
    • (2003) J. Clin. Invest , vol.111 , pp. 539-552
    • Mishra, N.1    Reilly, C.M.2    Brown, D.R.3    Ruiz, P.4    Gilkeson, G.S.5
  • 26
    • 84855448173 scopus 로고    scopus 로고
    • HDAC inhibitors: Modulating leukocyte differentiation, survival, proliferation and inflammation
    • Sweet, M. J., Shakespear, M. R., Kamal, N. A. & Fairlie, D. P. HDAC inhibitors: modulating leukocyte differentiation, survival, proliferation and inflammation. Immunol. Cell. Biol. 90, 14-22 (2012).
    • (2012) Immunol. Cell. Biol , vol.90 , pp. 14-22
    • Sweet, M.J.1    Shakespear, M.R.2    Kamal, N.A.3    Fairlie, D.P.4
  • 27
    • 79957932169 scopus 로고    scopus 로고
    • HDAC inhibition in lupus models
    • Reilly, C. M., Regna, N. & Mishra, N. HDAC inhibition in lupus models. Mol. Med. 17, 417-425 (2011).
    • (2011) Mol. Med , vol.17 , pp. 417-425
    • Reilly, C.M.1    Regna, N.2    Mishra, N.3
  • 28
    • 84859492923 scopus 로고    scopus 로고
    • HDAC inhibitor therapy in autoimmunity and transplantation
    • Hancock, W. W., Akimova, T., Beier, U. H., Liu, Y. & Wang, L. HDAC inhibitor therapy in autoimmunity and transplantation. Ann. Rheum. Dis. 71(Suppl 2): i46-i54 (2012).
    • (2012) Ann. Rheum. Dis , vol.71 , pp. i46-i54
    • Hancock, W.W.1    Akimova, T.2    Beier, U.H.3    Liu, Y.4    Wang, L.5
  • 29
    • 37649019847 scopus 로고    scopus 로고
    • Measuring lymphocyte proliferation, survival and differentiation using CFSE time-series data
    • Hawkins, E. D. et al. Measuring lymphocyte proliferation, survival and differentiation using CFSE time-series data. Nat. Protoc. 2, 2057-2067 (2007).
    • (2007) Nat. Protoc , vol.2 , pp. 2057-2067
    • Hawkins, E.D.1
  • 30
    • 33947238281 scopus 로고    scopus 로고
    • A model of immune regulation as a consequence of randomized lymphocyte division and death times
    • Hawkins, E. D., Turner, M. L., Dowling, M. R., van Gend, C. & Hodgkin, P. D. A model of immune regulation as a consequence of randomized lymphocyte division and death times. Proc. Natl Acad. Sci. USA 104, 5032-5037 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 5032-5037
    • Hawkins, E.D.1    Turner, M.L.2    Dowling, M.R.3    Van Gend, C.4    Hodgkin, P.D.5
  • 31
    • 84884156788 scopus 로고    scopus 로고
    • Quantal and graded stimulation of B lymphocytes as alternative strategies for regulating adaptive immune responses
    • Hawkins, E. D. et al. Quantal and graded stimulation of B lymphocytes as alternative strategies for regulating adaptive immune responses. Nat. Commun. 4, 2406 (2013).
    • (2013) Nat. Commun , vol.4 , pp. 2406
    • Hawkins, E.D.1
  • 32
    • 47949086920 scopus 로고    scopus 로고
    • Quantitative regulation of B cell division destiny by signal strength
    • Turner, M. L., Hawkins, E. D. & Hodgkin, P. D. Quantitative regulation of B cell division destiny by signal strength. J. Immunol. 181, 374-382 (2008).
    • (2008) J. Immunol , vol.181 , pp. 374-382
    • Turner, M.L.1    Hawkins, E.D.2    Hodgkin, P.D.3
  • 33
    • 0035054598 scopus 로고    scopus 로고
    • B cells activated via CD40 and IL-4 undergo a division burst but require continued stimulation to maintain division, survival and differentiation
    • Rush, J. S. & Hodgkin, P. D. B cells activated via CD40 and IL-4 undergo a division burst but require continued stimulation to maintain division, survival and differentiation. Eur. J. Immunol. 31, 1150-1159 (2001).
    • (2001) Eur. J. Immunol , vol.31 , pp. 1150-1159
    • Rush, J.S.1    Hodgkin, P.D.2
  • 34
    • 13444274622 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
    • Insinga, A. et al. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat. Med. 11, 71-76 (2005).
    • (2005) Nat. Med , vol.11 , pp. 71-76
    • Insinga, A.1
  • 35
    • 42449130607 scopus 로고    scopus 로고
    • HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen
    • Li, N. et al. HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen. Proc. Natl Acad. Sci. USA 105, 4796-4801 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 4796-4801
    • Li, N.1
  • 36
    • 84864020953 scopus 로고    scopus 로고
    • LBH589 enhances T cell activation in vivo and accelerates graft-versus-host disease in mice
    • e1181
    • Wang, D. et al. LBH589 enhances T cell activation in vivo and accelerates graft-versus-host disease in mice. Biol. Blood Marrow Transplant. 18, 1182-1190 e1181 (2012).
    • (2012) Biol. Blood Marrow Transplant , vol.18 , pp. 1182-1190
    • Wang, D.1
  • 37
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A. & Nagata, S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317 (1992).
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 38
    • 84884996251 scopus 로고    scopus 로고
    • Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk∗MYC multiple myeloma
    • Matthews, G. M. et al. Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk∗MYC multiple myeloma. Cell Death Dis. 4, e798 (2013).
    • (2013) Cell Death Dis , vol.4 , pp. e798
    • Matthews, G.M.1
  • 39
    • 84884699420 scopus 로고    scopus 로고
    • PANORAMA 2: Panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomibrefractory myeloma
    • Richardson, P. G. et al. PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomibrefractory myeloma. Blood 122, 2331-2337 (2013).
    • (2013) Blood , vol.122 , pp. 2331-2337
    • Richardson, P.G.1
  • 40
  • 41
    • 0030740148 scopus 로고    scopus 로고
    • Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation
    • Chan, V. W., Meng, F., Soriano, P., DeFranco, A. L. & Lowell, C. A. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7, 69-81 (1997).
    • (1997) Immunity , vol.7 , pp. 69-81
    • Chan, V.W.1    Meng, F.2    Soriano, P.3    Defranco, A.L.4    Lowell, C.A.5
  • 42
    • 0028784215 scopus 로고
    • Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
    • Hibbs, M. L. et al. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83, 301-311 (1995).
    • (1995) Cell , vol.83 , pp. 301-311
    • Hibbs, M.L.1
  • 43
    • 0028806216 scopus 로고
    • Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
    • Nishizumi, H. et al. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 3, 549-560 (1995).
    • (1995) Immunity , vol.3 , pp. 549-560
    • Nishizumi, H.1
  • 44
    • 77954649027 scopus 로고    scopus 로고
    • BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs
    • Carrington, E. M. et al. BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs. Proc. Natl Acad. Sci. USA 107, 10967-10971 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 10967-10971
    • Carrington, E.M.1
  • 45
    • 0034798017 scopus 로고    scopus 로고
    • Spontaneous formation of germinal centers in autoimmune mice
    • Luzina, I. G. et al. Spontaneous formation of germinal centers in autoimmune mice. J. Leukoc. Biol. 70, 578-584 (2001).
    • (2001) J. Leukoc. Biol , vol.70 , pp. 578-584
    • Luzina, I.G.1
  • 46
    • 62849120700 scopus 로고    scopus 로고
    • Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance
    • Wang, L., Tao, R. & Hancock, W. W. Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. Immunol. Cell. Biol. 87, 195-202 (2009).
    • (2009) Immunol. Cell. Biol , vol.87 , pp. 195-202
    • Wang, L.1    Tao, R.2    Hancock, W.W.3
  • 47
    • 79952396960 scopus 로고    scopus 로고
    • Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
    • Bantscheff, M. et al. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat. Biotechnol. 29, 255-265 (2011).
    • (2011) Nat. Biotechnol , vol.29 , pp. 255-265
    • Bantscheff, M.1
  • 48
    • 14844353574 scopus 로고    scopus 로고
    • Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors
    • Peart, M. J. et al. Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. Proc. Natl Acad. Sci. USA 102, 3697-3702 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 3697-3702
    • Peart, M.J.1
  • 49
    • 49849103540 scopus 로고    scopus 로고
    • Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin
    • Newbold, A. et al. Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin. Mol. Cancer Ther. 7, 1066-1079 (2008).
    • (2008) Mol. Cancer Ther , vol.7 , pp. 1066-1079
    • Newbold, A.1
  • 50
    • 0242302583 scopus 로고    scopus 로고
    • The genetics of human systemic lupus erythematosus
    • Tsao, B. P. The genetics of human systemic lupus erythematosus. Trends Immunol. 24, 595-602 (2003).
    • (2003) Trends Immunol , vol.24 , pp. 595-602
    • Tsao, B.P.1
  • 51
    • 74849131972 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial
    • Merrill, J. T. et al. Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum. 62, 222-233 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 222-233
    • Merrill, J.T.1
  • 52
    • 84866184129 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The Lupus Nephritis Assessment with Rituximab study
    • Rovin, B. H. et al. Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study. Arthritis Rheum. 64, 1215-1226 (2012).
    • (2012) Arthritis Rheum , vol.64 , pp. 1215-1226
    • Rovin, B.H.1
  • 53
    • 84875978060 scopus 로고    scopus 로고
    • HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
    • Bolden, J. E. et al. HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses. Cell Death Dis. 4, e519 (2013).
    • (2013) Cell Death Dis , vol.4 , pp. e519
    • Bolden, J.E.1
  • 54
    • 78449282121 scopus 로고    scopus 로고
    • Mcl-1 is essential for germinal center formation and B cell memory
    • Vikstrom, I. et al. Mcl-1 is essential for germinal center formation and B cell memory. Science 330, 1095-1099 (2010).
    • (2010) Science , vol.330 , pp. 1095-1099
    • Vikstrom, I.1
  • 55
    • 84881478015 scopus 로고    scopus 로고
    • Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies
    • Deangelo, D. J. et al. Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies. Leukemia 27, 1628-1636 (2013).
    • (2013) Leukemia , vol.27 , pp. 1628-1636
    • Deangelo, D.J.1
  • 56
    • 0025875259 scopus 로고
    • Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease
    • Cohen, P. L. & Eisenberg, R. A. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9, 243-269 (1991).
    • (1991) Annu. Rev. Immunol , vol.9 , pp. 243-269
    • Cohen, P.L.1    Eisenberg, R.A.2
  • 57
    • 77949322552 scopus 로고    scopus 로고
    • Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6
    • Tsantikos, E. et al. Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. J. Immunol. 184, 1348-1360 (2010).
    • (2010) J. Immunol , vol.184 , pp. 1348-1360
    • Tsantikos, E.1
  • 58
    • 0030925491 scopus 로고    scopus 로고
    • The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
    • Smith, K. G., Light, A., Nossal, G. J. & Tarlinton, D. M. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J. 16, 2996-3006 (1997).
    • (1997) EMBO J. , vol.16 , pp. 2996-3006
    • Smith, K.G.1    Light, A.2    Nossal, G.J.3    Tarlinton, D.M.4
  • 59
    • 0034614896 scopus 로고    scopus 로고
    • Bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells
    • Smith, K. G. et al. bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells. J. Exp. Med. 191, 475-484 (2000).
    • (2000) J. Exp. Med , vol.191 , pp. 475-484
    • Smith, K.G.1
  • 60
    • 84877760790 scopus 로고    scopus 로고
    • Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity
    • 1801
    • Hawkins, E. D. et al. Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity. Nat. Commun. 4, 1801 (2013).
    • (2013) Nat. Commun , vol.4
    • Hawkins, E.D.1
  • 61
    • 0021153603 scopus 로고
    • Diffuse proliferative lupus nephritis: Identification of specific pathologic features affecting renal outcome
    • Austin, III H. A. et al. Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome. Kidney Int. 25, 689-695 (1984).
    • (1984) Kidney Int , vol.25 , pp. 689-695
    • Austin, H.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.