Histone deacetylase inhibitor Trichostatin A reduces anti-DNA autoantibody production and represses IgH gene transcription

Biochemical and Biophysical Research Communications

Volumn 330, Issue 1, 2005, Pages 204-209

  Lu, Zhong Ping ^a,b   Ju, Zhong Liang ^a   Shi, Guang Yin ^a   Zhang, Jing Wu ^a   Sun, Jian ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

3 IgH enhancers; Autoantibody; Histone acetylation; Histone deacetylases; IgH gene transcription; IgH intronic enhancer (E ); IgH promoter; Trichostatin A

Indexed keywords

ENZYME INHIBITOR; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; TRICHOSTATIN A;

ANIMAL CELL; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL LINE; CHROMATIN; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SPLEEN CELL;

EID: 15444377542     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.02.147     Document Type: Article

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