Antimicrobial peptide LL-37 is both a substrate of cathepsins S and K and a selective inhibitor of cathepsin L

Biochemistry

Volumn 54, Issue 17, 2015, Pages 2785-2798

  Andrault, Pierre Marie ^a   Samsonov, Sergey A ^b   Weber, Gunther ^c   Coquet, Laurent ^d   Nazmi, Kamran ^e   Bolscher, Jan G M ^e   Lalmanach, Anne Christine ^a   Jouenne, Thierry ^d   Brömme, Dieter ^f   Pisabarro, M Teresa ^b   Lalmanach, Gilles ^a   Lecaille, Fabien ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c CHRU de Tours   (France)

^d UNIVERSITÉ DE ROUEN   (France)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; BINDING ENERGY; HYDROLYSIS; PEPTIDES; POLYPEPTIDES;

ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; CONCENTRATION-DEPENDENT MANNERS; PATHOLOGICAL PROCESS; PEPTIDASE INHIBITORS; PSEUDOMONAS AERUGINOSA; SELECTIVE INHIBITORS; STAPHYLOCOCCUS AUREUS;

MICROORGANISMS;

ADENOSINE PHOSPHATE; ALANINE; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; LEUCINE; TYROSINE; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; CATHEPSIN; CYSTEINE PROTEINASE INHIBITOR;

ADULT; ANTIMICROBIAL ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME ACTIVE SITE; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; SPUTUM ANALYSIS; STAPHYLOCOCCUS AUREUS; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CIRCULAR DICHROISM; DRUG EFFECTS; ENZYME SPECIFICITY; LUNG LAVAGE; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR GENETICS;

PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; ANTIMICROBIAL CATIONIC PEPTIDES; BRONCHOALVEOLAR LAVAGE FLUID; CATHEPSIN K; CATHEPSIN L; CATHEPSINS; CIRCULAR DICHROISM; CYSTEINE PROTEINASE INHIBITORS; CYSTIC FIBROSIS; HUMANS; MACROPHAGES, ALVEOLAR; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PSEUDOMONAS AERUGINOSA; SUBSTRATE SPECIFICITY;

EID: 84928963891     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00231     Document Type: Article

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