Binding of chondroitin 4-sulfate to cathepsin S regulates its enzymatic activity

Biochemistry

Volumn 52, Issue 37, 2013, Pages 6487-6498

  Sage, Juliette ^a,b   Mallèvre, Florian ^c   Barbarin Costes, Fabien ^a   Samsonov, Sergey A ^d   Gehrcke, Jan Philip ^d   Pisabarro, Maria Teresa ^d   Perrier, Eric ^b   Schnebert, Sylvianne ^b   Roget, Andre ^c   Livache, Thierry ^c   Nizard, Carine ^b,e   Lalmanach, Gilles ^a   Lecaille, Fabien ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b Parfums Christian Dior   (France)

^c CEA GRENOBLE   (France)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE ACTIVITY; COLLAGENOLYTIC ACTIVITIES; CONFORMATIONAL CHANGE; DOSE-DEPENDENT MANNER; ENZYMATIC ACTIVITIES; EQUILIBRIUM DISSOCIATION CONSTANT; GEL-FILTRATION CHROMATOGRAPHY; THERAPEUTIC TARGETS;

AMINO ACIDS; DISEASES; DISSOCIATION; FLUORESCENCE SPECTROSCOPY; HYALURONIC ACID;

SULFUR COMPOUNDS;

CATHEPSIN K; CATHEPSIN S; CHONDROITIN 4 SULFATE; CHONDROITIN 6 SULFATE; COLLAGEN TYPE 4; DERMATAN SULFATE; HEPARAN SULFATE; HEPARIN; HYALURONIC ACID; SODIUM CHLORIDE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; GEL FILTRATION CHROMATOGRAPHY; GEL PERMEATION CHROMATOGRAPHY; HOMEOSTASIS; HYDROLYSIS; MOLECULAR DOCKING; MOLECULAR INTERACTION; PH; PREDICTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; STATIC ELECTRICITY; SURFACE PLASMON RESONANCE;

BINDING SITES; CATHEPSINS; CHONDROITIN SULFATES; CHROMATOGRAPHY, GEL; COLLAGEN TYPE IV; COUMARINS; DIPEPTIDES; HUMANS; KINETICS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; SURFACE PLASMON RESONANCE;

EID: 84884275724     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400925g     Document Type: Article

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