The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 18, 2015, Pages E2307-E2316

  Neugebauer, Judith M ^a   Kwon, Sunjong ^b,c   Kim, Hyung Seok ^a   Donley, Nathan ^b   Tilak, Anup ^b   Sopory, Shailaja ^b,d   Christian, Jan L ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Oregon Health and Science University Department of Biomedical Engineering   (United States)

^d Translational Health Science and Technology Institute   (India)

Author keywords

BMP4; BMP7; Bone morphogenetic protein; Heterodimer; Prodomain

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CHIMERIC PROTEIN; HETERODIMER; HOMODIMER; OSTEOGENIC PROTEIN 1; PROTEIN PRECURSOR; RNA; SMAD1 PROTEIN; BMP4 PROTEIN, MOUSE; BMP7 PROTEIN, MOUSE; EPITOPE; LIGAND; PROTEIN BINDING; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EMBRYO; ARTICLE; BIOLOGICAL ACTIVITY; BLASTOMA; CONTROLLED STUDY; EMBRYO; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VIVO STUDY; MESODERMAL CELL; MOLECULAR STABILITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN SYNTHESIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; WILD TYPE; XENOPUS; ANIMAL; CHEMISTRY; GENE EXPRESSION REGULATION; HEK293 CELL LINE; HUMAN; MOUSE; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 7; EPITOPES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEK293 CELLS; HUMANS; LIGANDS; MICE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; XENOPUS;

EID: 84928942254     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1501449112     Document Type: Article

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