Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling

International Journal of Cancer

Volumn 103, Issue 4, 2003, Pages 455-465

  Midorikawa, Yutaka ^a,b   Ishikawa, Shumpei ^a   Iwanari, Hiroko ^c   Imamura, Takeshi ^d   Sakamoto, Hirohiko ^e   Miyazono, Kohei ^d   Kodama, Tatsuhiko ^a   Makuuchi, Masatoshi ^b   Aburatani, Hiroyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Institute of Immunology Co Ltd   (Japan)

^d CANCER INSTITUTE   (Japan)

^e SAITAMA CANCER CENTER   (Japan)

Author keywords

Cell proliferation; Heparan sulfate proteoglycan; Heparin binding growth factors; Hepatocarcinogenesis; Tumor marker

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; GENE PRODUCT; GLYPICAN; GLYPICAN 3; MONOCLONAL ANTIBODY; OSTEOGENIC PROTEIN 1; PROTEOHEPARAN SULFATE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MODULATION; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AGED; ANTIBODIES, MONOCLONAL; BLOTTING, NORTHERN; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEINS; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROBLAST GROWTH FACTOR 2; GENES, REPORTER; GENETIC VECTORS; GLYPICANS; HEPARAN SULFATE PROTEOGLYCANS; HUMANS; IMMUNOHISTOCHEMISTRY; LIGANDS; LIVER NEOPLASMS; LUCIFERASES; MALE; MIDDLE AGED; PLASMIDS; PROTEIN BINDING; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD PROTEINS; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 0037428667     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10856     Document Type: Article

References (34)

1. Filmus J, Selleck SB. Glypicans: Proteoglycans with a surprise. J Clin Invest 2001;108:497-501.
2. Zhang Z, Coomans C, David G. Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling. Evidence in support of the "cooperative end structures" model. J Biol Chem 2001;276:41921-9.
3. Paine-Saunders S, Viviano BL, Zupicich J, Skarnes WC, Saunders S. Glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol 2000;225:179-87.
4. Grisaru S, Cano-Gauci, Tee J, Filmus J, Rosenblum ND. Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis. Dev Biol 2001;231:31-46.
5. Mali M, Elenius K, Miettinen HM, Jalkanen M. Inhibition of basic fibroblast growth factor-induced growth promotion by overexpression of syndecan-1. J Biol Chem 1993;268:24215-22.
6. Forsten KE, Courant NA, Nugent MA. Endothelial proteoglycans inhibit bFGF binding and mitogenesis. J Cell Physiol 1997;172:209-20.
7. Filla MS, Dam P, Rapraeger AC. The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity. J Cell Physiol 1998;174:310-21.
8. Clasper S, Vekemans S, Fiore M, Plebanski M, Wordsworth P, David G, Jackson DG. Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 (fibroglycan) on human activated macrophages can regulate fibroblast growth factor action. J Biol Chem 1999;274:24113-23.
9. Clayton A, Thomas J, Thomas GJ, Davies M, Steadman R. Cell surface heparan sulfate proteoglycans control the response of renal interstitial fibroblasts to fibroblast growth factor-2. Kidney Int 2001;59:2084-94.
10. Piscione TD, Phan T, Rosenblum ND. BMP7 controls collecting tubule cell proliferation and apoptosis via Smadl-dependent and -independent pathways. Am J Physiol Renal Physiol 2001;280:F19-33.
11. Pilia G, Hughes-Benzie RM, MacKenzie A, Baybayan P, Chen EY, Huber R, Neri G, Cao A, Forabosco A, Schlessinger D. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Nat Genet 1996;12:241-7.
12. Song HH, Shi W, Filmus J. OCI-5/rat glypican-3 binds to fibroblast growth factor-2 but not to insulin-like growth factor-2. J Biol Chem 1997;272:7574-7.
13. Gonzalez AD, Kaya M, Shi W, Song H, Testa JR, Penn LZ, Filmus J. OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner. J Cell Biol 1998;141:1407-14.
14. Lin H, Huber R, Schlessinger D, Morin PJ. Frequent silencing of the GPC3 gene in ovarian cancer cell lines. Cancer Res 1999;59:807-10.
15. Murthy SS, Shen T, De Rienzo A, Lee WC, Ferriola PC, Jhanwar SC, Mossman BT, Filmus J, Testa JR. Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma. Oncogene 2000;19:410-6.
16. Saikali Z, Sinnett D. Expression of glypican 3 (GPC3) in embryonal tumors. Int J Cancer 2000;89:418-22.
17. Lage H, Dietel M, Froschle G, Reymann A. Expression of the novel mitoxantrone resistance associated gene MXR7 in colorectal malignancies. Int J Clin Pharmacol Ther 1998;36:58-60.
18. Hsu HC, Cheng W, Lai PL. Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: Biological significance and temporospatial distribution. Cancer Res 1997;57:5179-84.
19. Zhu ZW, Friess H, Wang L, Abou-Shady M, Zimmermann A, Lander AD, Korc M, Kleeff J, Buchler MW. Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders. Gut 2001;48:558-64.
20. Tsuda H, Oda T, Sakamoto M, Hirohashi S. Different pattern of chromosomal allele loss in multiple hepatocellular carcinomas as evidence of their multifocal origin. Cancer Res 1992;52:1504-9.
21. Huang Y, Uchiyama Y, Fujimura T, Kanamori H, Doi T, Takamizawa A, Hamakubo T, Kodama T. A human hepatoma cell line expressing hepatitis c virus nonstructural proteins tightly regulated by tetracycline. Biochem Biophys Res Commun 2001;281:732-40.
22. Hippo Y, Yashiro M, Ishii M, Taniguchi H, Tsutsumi S, Hirakawa K, Kodama T, Aburatani H. Differential gene expression profiles of scirrhus gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. Cancer Res 2001;61:889-95.
23. Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-7.
24. Matsuda K, Maruyama H, Guo F, Kleeff J, Itakura J, Matsumoto Y, Lander AD, Korc M. Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells. Cancer Res 2001;61:5562-9.
25. Ishida W, Hamamoto T, Kusanagi K, Yagi K, Kawabata M, Takehara K, Sampath TK, Kato M, Miyazono K. Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter. J Biol Chem 2000;275:6075-9.
26. Kleeff J, Ishiwata T, Kumbasar A, Friess H, Buchler MW, Lander AD, Korc M. The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer. J Clin Invest 1998;102:1662-73.
27. Matsuda K, Maruyama H, Guo F, Kleeff J, Itakura J, Matsumoto Y, Lander AD, Korc M. Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells. Cancer Res 2001;61:5562-9.
28. Blackball FH, Merry CL, Davies EJ, Jayson GC. Heparan sulfate proteoglycans and cancer. Br J Cancer 2001;85:1094-8.
29. Ludwig T, Eggenschwiler J, Fisher P, D'Ercole AJ, Davenport ML, Efstratiadis A. Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Dev Biol 1996;177:517-35.
30. Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991;64:841-8.
31. Steinfeld R, Van Den Berghe H, David G. Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican. J Cell Biol 1996;133:405-16.
32. Clasper S, Vekemans S, Fiore M, Plebanski M, Wordsworth P, David G, Jackson DG. Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 (fibroglycan) on human activated macrophages can regulate fibroblast growth factor action. J Biol Chem 1999;274:24113-23.
33. Thompson SA, Higashiyama S, Wood K, Pollitt NS, Damm D, McEnroe G, Garrick B, Ashton N, Lau K, Hancock N, Klagsbrun N, Abraham JA. Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin. J Biol Chem 1994;269:2541-9.
34. Cano-Gauci DF, Song HH, Yang H, McKerlie C, Choo B, Shi W, Pullano R, Piscione TD, Grisaru S, Soon S, Sedlackova L, Tanswell AK, et al. Glypican-3-deficient mice exhibit developmental over-growth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol 1999;146:255-64.