메뉴 건너뛰기




Volumn 23, Issue 1-2, 2012, Pages 61-67

The signaling and functions of heterodimeric bone morphogenetic proteins

Author keywords

Bone; Bone morphogenetic protein; Heterodimer; Heterodimeric; Homodimeric; Signaling

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 12; BONE MORPHOGENETIC PROTEIN 15; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 5; BONE MORPHOGENETIC PROTEIN 6; BONE MORPHOGENETIC PROTEIN 9; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CHORDIN; GROWTH DIFFERENTIATION FACTOR 10; GROWTH DIFFERENTIATION FACTOR 3; GROWTH DIFFERENTIATION FACTOR 6; GROWTH DIFFERENTIATION FACTOR 9; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOSTATIN; NOGGIN; OSTEOGENIC PROTEIN 1; OSTEOGENIN; PROCOLLAGEN C PROTEINASE; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RUNX2;

EID: 84858332746     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2012.02.001     Document Type: Short Survey
Times cited : (76)

References (73)
  • 1
    • 34250019537 scopus 로고
    • Bone: formation by autoinduction
    • Urist M.R. Bone: formation by autoinduction. Science 1965, 150:893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 3
    • 71449108623 scopus 로고    scopus 로고
    • Bone morphogenetic proteins (BMPs): from morphogens to metabologens
    • Reddi A.H., Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev 2009, 20:341-342.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 341-342
    • Reddi, A.H.1    Reddi, A.2
  • 4
    • 0034128748 scopus 로고    scopus 로고
    • The family of bone morphogenetic proteins
    • Ducy P., Karsenty G. The family of bone morphogenetic proteins. Kidney Int 2000, 57:2207-2214.
    • (2000) Kidney Int , vol.57 , pp. 2207-2214
    • Ducy, P.1    Karsenty, G.2
  • 5
    • 21344434155 scopus 로고    scopus 로고
    • BMPs: from bone morphogenetic proteins to body morphogenetic proteins
    • Reddi A.H. BMPs: from bone morphogenetic proteins to body morphogenetic proteins. Cytokine Growth Factor Rev 2005, 16:249-250.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 249-250
    • Reddi, A.H.1
  • 6
    • 43949090746 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic. Part I (basic concepts)
    • Bessa P.C., Casal M., Reis R.L. Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic. Part I (basic concepts). J Tissue Eng Regen Med 2008, 2:1-13.
    • (2008) J Tissue Eng Regen Med , vol.2 , pp. 1-13
    • Bessa, P.C.1    Casal, M.2    Reis, R.L.3
  • 7
    • 0037423198 scopus 로고    scopus 로고
    • Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep
    • Liao W.X., Moore R.K., Otsuka F., Shimasaki S. Effect of intracellular interactions on the processing and secretion of bone morphogenetic protein-15 (BMP-15) and growth and differentiation factor-9. Implication of the aberrant ovarian phenotype of BMP-15 mutant sheep. J Biol Chem 2003, 278:3713-3719.
    • (2003) J Biol Chem , vol.278 , pp. 3713-3719
    • Liao, W.X.1    Moore, R.K.2    Otsuka, F.3    Shimasaki, S.4
  • 11
    • 0025323376 scopus 로고
    • Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily
    • Sampath T.K., Coughlin J.E., Whetstone R.M., Banach D., Corbett C., Ridge R.J., et al. Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. J Biol Chem 1990, 265:13198-13205.
    • (1990) J Biol Chem , vol.265 , pp. 13198-13205
    • Sampath, T.K.1    Coughlin, J.E.2    Whetstone, R.M.3    Banach, D.4    Corbett, C.5    Ridge, R.J.6
  • 12
    • 0028024341 scopus 로고
    • Bone morphogenetic proteins induce differentiation in astrocyte lineage cells
    • D'Alessandro J.S., Yetz-Aldape J., Wang E.A. Bone morphogenetic proteins induce differentiation in astrocyte lineage cells. Growth Factors 1994, 11:53-69.
    • (1994) Growth Factors , vol.11 , pp. 53-69
    • D'Alessandro, J.S.1    Yetz-Aldape, J.2    Wang, E.A.3
  • 13
    • 0029028648 scopus 로고
    • Efficient expression of a heterodimer of bone morphogenetic protein subunits using a baculovirus expression system
    • Hazama M., Aono A., Ueno N., Fujisawa Y. Efficient expression of a heterodimer of bone morphogenetic protein subunits using a baculovirus expression system. Biochem Biophys Res Commun 1995, 209:859-866.
    • (1995) Biochem Biophys Res Commun , vol.209 , pp. 859-866
    • Hazama, M.1    Aono, A.2    Ueno, N.3    Fujisawa, Y.4
  • 15
    • 0029862206 scopus 로고    scopus 로고
    • Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo
    • Israel D.I., Nove J., Kerns K.M., Kaufman R.J., Rosen V., Cox K.A., et al. Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo. Growth Factors 1996, 13:291-300.
    • (1996) Growth Factors , vol.13 , pp. 291-300
    • Israel, D.I.1    Nove, J.2    Kerns, K.M.3    Kaufman, R.J.4    Rosen, V.5    Cox, K.A.6
  • 16
    • 23844546987 scopus 로고    scopus 로고
    • Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7
    • Zhao M., Zhao Z., Koh J.T., Jin T.C., Franceschi R.T. Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7. J Cell Biochem 2005, 95:1-16.
    • (2005) J Cell Biochem , vol.95 , pp. 1-16
    • Zhao, M.1    Zhao, Z.2    Koh, J.T.3    Jin, T.C.4    Franceschi, R.T.5
  • 17
    • 77649263952 scopus 로고    scopus 로고
    • RhBMP2/7 heterodimer: an osteoblastogenesis inducer of not higher potency but lower effective concentration compared with rhBMP2 and rhBMP7 homodimers
    • Zheng Y., Wu G., Zhao J., Wang L., Sun P., Gu Z. rhBMP2/7 heterodimer: an osteoblastogenesis inducer of not higher potency but lower effective concentration compared with rhBMP2 and rhBMP7 homodimers. Tissue Eng A 2010, 16:879-887.
    • (2010) Tissue Eng A , vol.16 , pp. 879-887
    • Zheng, Y.1    Wu, G.2    Zhao, J.3    Wang, L.4    Sun, P.5    Gu, Z.6
  • 18
    • 77956216369 scopus 로고    scopus 로고
    • BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells
    • Valera E., Isaacs M.J., Kawakami Y., Izpisua Belmonte J.C., Choe S. BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells. PLoS One 2010, 5:e11167.
    • (2010) PLoS One , vol.5
    • Valera, E.1    Isaacs, M.J.2    Kawakami, Y.3    Izpisua Belmonte, J.C.4    Choe, S.5
  • 19
    • 0038242149 scopus 로고    scopus 로고
    • A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons
    • Butler S.J., Dodd J. A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons. Neuron 2003, 38:389-401.
    • (2003) Neuron , vol.38 , pp. 389-401
    • Butler, S.J.1    Dodd, J.2
  • 20
    • 84858336789 scopus 로고    scopus 로고
    • A BMP2/7 fusion gene enhances osteoblastic differentiation in mesenchymal cells
    • Zhu W., Boachie-Adjei O., Rawlins B., Crystal R.G., Hidaka C. A BMP2/7 fusion gene enhances osteoblastic differentiation in mesenchymal cells. Mol Ther 2004, 9:S338.
    • (2004) Mol Ther , vol.9
    • Zhu, W.1    Boachie-Adjei, O.2    Rawlins, B.3    Crystal, R.G.4    Hidaka, C.5
  • 21
    • 77954828817 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly
    • Isaacs M.J., Kawakami Y., Allendorph G.P., Yoon B.H., Belmonte J.C., Choe S. Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly. Mol Endocrinol 2010, 24:1469-1477.
    • (2010) Mol Endocrinol , vol.24 , pp. 1469-1477
    • Isaacs, M.J.1    Kawakami, Y.2    Allendorph, G.P.3    Yoon, B.H.4    Belmonte, J.C.5    Choe, S.6
  • 22
    • 21344464386 scopus 로고    scopus 로고
    • Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model
    • Zhu W., Rawlins B.A., Boachie-Adjei O., Myers E.R., Arimizu J., Choi E., et al. Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. J Bone Miner Res 2004, 19:2021-2032.
    • (2004) J Bone Miner Res , vol.19 , pp. 2021-2032
    • Zhu, W.1    Rawlins, B.A.2    Boachie-Adjei, O.3    Myers, E.R.4    Arimizu, J.5    Choi, E.6
  • 23
    • 69849086901 scopus 로고    scopus 로고
    • Expression of BMP-2/7 heterodimers with potent ability to stimulate osteogenic differentiation in CHO cells
    • Pan Q., Yang S., Sun F. Expression of BMP-2/7 heterodimers with potent ability to stimulate osteogenic differentiation in CHO cells. Sheng Wu Gong Cheng Xue Bao 2008, 24:473-479.
    • (2008) Sheng Wu Gong Cheng Xue Bao , vol.24 , pp. 473-479
    • Pan, Q.1    Yang, S.2    Sun, F.3
  • 24
    • 77649250084 scopus 로고    scopus 로고
    • Relationship between the bioactivity of BMP2/7 heterodimers and its regulation of CIZ expression
    • Pan Q., Yang S., Dong Q., Sun F. Relationship between the bioactivity of BMP2/7 heterodimers and its regulation of CIZ expression. China Biotechnol 2007, 27:14-18.
    • (2007) China Biotechnol , vol.27 , pp. 14-18
    • Pan, Q.1    Yang, S.2    Dong, Q.3    Sun, F.4
  • 26
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R., Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003, 425:577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 27
    • 51049098368 scopus 로고    scopus 로고
    • BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells
    • Lavery K., Swain P., Falb D., Alaoui-Ismaili M.H. BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem 2008, 283:20948-20958.
    • (2008) J Biol Chem , vol.283 , pp. 20948-20958
    • Lavery, K.1    Swain, P.2    Falb, D.3    Alaoui-Ismaili, M.H.4
  • 28
    • 75649127963 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptors and signal transduction
    • Miyazono K., Kamiya Y., Morikawa M. Bone morphogenetic protein receptors and signal transduction. J Biochem 2010, 147:35-51.
    • (2010) J Biochem , vol.147 , pp. 35-51
    • Miyazono, K.1    Kamiya, Y.2    Morikawa, M.3
  • 29
    • 0032994043 scopus 로고    scopus 로고
    • Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins
    • Miyazono K. Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins. Bone 1999, 25:91-93.
    • (1999) Bone , vol.25 , pp. 91-93
    • Miyazono, K.1
  • 31
    • 0347991862 scopus 로고    scopus 로고
    • Integration of Smad and MAPK pathways: a link and a linker revisited
    • Massague J. Integration of Smad and MAPK pathways: a link and a linker revisited. Genes Dev 2003, 17:2993-2997.
    • (2003) Genes Dev , vol.17 , pp. 2993-2997
    • Massague, J.1
  • 32
    • 22844440947 scopus 로고    scopus 로고
    • Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors
    • Hoffmann A., Preobrazhenska O., Wodarczyk C., Medler Y., Winkel A., Shahab S., et al. Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors. J Biol Chem 2005, 280:27271-27283.
    • (2005) J Biol Chem , vol.280 , pp. 27271-27283
    • Hoffmann, A.1    Preobrazhenska, O.2    Wodarczyk, C.3    Medler, Y.4    Winkel, A.5    Shahab, S.6
  • 33
    • 79958768845 scopus 로고    scopus 로고
    • Homomeric and heteromeric complexes among TGF-beta and BMP receptors and their roles in signaling
    • Ehrlich M., Horbelt D., Marom B., Knaus P., Henis Y.I. Homomeric and heteromeric complexes among TGF-beta and BMP receptors and their roles in signaling. Cell Signal 2011, 23:1424-1432.
    • (2011) Cell Signal , vol.23 , pp. 1424-1432
    • Ehrlich, M.1    Horbelt, D.2    Marom, B.3    Knaus, P.4    Henis, Y.I.5
  • 35
    • 0034600953 scopus 로고    scopus 로고
    • BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II
    • Kirsch T., Nickel J., Sebald W. BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. EMBO J 2000, 19:3314-3324.
    • (2000) EMBO J , vol.19 , pp. 3314-3324
    • Kirsch, T.1    Nickel, J.2    Sebald, W.3
  • 36
    • 4544286802 scopus 로고    scopus 로고
    • Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction
    • Sebald W., Nickel J., Zhang J.L., Mueller T.D. Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction. Biol Chem 2004, 385:697-710.
    • (2004) Biol Chem , vol.385 , pp. 697-710
    • Sebald, W.1    Nickel, J.2    Zhang, J.L.3    Mueller, T.D.4
  • 37
    • 35648944164 scopus 로고    scopus 로고
    • BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors
    • Allendorph G.P., Isaacs M.J., Kawakami Y., Izpisua Belmonte J.C., Choe S. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. Biochemistry 2007, 46:12238-12247.
    • (2007) Biochemistry , vol.46 , pp. 12238-12247
    • Allendorph, G.P.1    Isaacs, M.J.2    Kawakami, Y.3    Izpisua Belmonte, J.C.4    Choe, S.5
  • 38
    • 37349118993 scopus 로고    scopus 로고
    • Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand
    • Saremba S., Nickel J., Seher A., Kotzsch A., Sebald W., Mueller T.D. Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand. FEBS J 2008, 275:172-183.
    • (2008) FEBS J , vol.275 , pp. 172-183
    • Saremba, S.1    Nickel, J.2    Seher, A.3    Kotzsch, A.4    Sebald, W.5    Mueller, T.D.6
  • 40
    • 84860314217 scopus 로고    scopus 로고
    • The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation
    • Buijs J.T., van der Horst G., van den Hoogen C., Cheung H., de Rooij B., Kroon J., et al. The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation. Oncogene 2011, 10.1038/onc.2011.400.
    • (2011) Oncogene
    • Buijs, J.T.1    van der Horst, G.2    van den Hoogen, C.3    Cheung, H.4    de Rooij, B.5    Kroon, J.6
  • 41
    • 0037085287 scopus 로고    scopus 로고
    • The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways
    • Nohe A., Hassel S., Ehrlich M., Neubauer F., Sebald W., Henis Y.I., et al. The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem 2002, 277:5330-5338.
    • (2002) J Biol Chem , vol.277 , pp. 5330-5338
    • Nohe, A.1    Hassel, S.2    Ehrlich, M.3    Neubauer, F.4    Sebald, W.5    Henis, Y.I.6
  • 42
    • 0041885046 scopus 로고    scopus 로고
    • Effect of the distribution and clustering of the type I A BMP receptor (ALK3) with the type II BMP receptor on the activation of signalling pathways
    • Nohe A., Keating E., Underhill T.M., Knaus P., Petersen N.O. Effect of the distribution and clustering of the type I A BMP receptor (ALK3) with the type II BMP receptor on the activation of signalling pathways. J Cell Sci 2003, 116:3277-3284.
    • (2003) J Cell Sci , vol.116 , pp. 3277-3284
    • Nohe, A.1    Keating, E.2    Underhill, T.M.3    Knaus, P.4    Petersen, N.O.5
  • 43
    • 70350037984 scopus 로고    scopus 로고
    • Receptor oligomerization and beyond: a case study in bone morphogenetic proteins
    • Heinecke K., Seher A., Schmitz W., Mueller T.D., Sebald W., Nickel J. Receptor oligomerization and beyond: a case study in bone morphogenetic proteins. BMC Biol 2009, 7:59.
    • (2009) BMC Biol , vol.7 , pp. 59
    • Heinecke, K.1    Seher, A.2    Schmitz, W.3    Mueller, T.D.4    Sebald, W.5    Nickel, J.6
  • 44
    • 70649099961 scopus 로고    scopus 로고
    • Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad
    • Eivers E., Demagny H., De Robertis E.M. Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad. Cytokine Growth Factor Rev 2009, 20:357-365.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 357-365
    • Eivers, E.1    Demagny, H.2    De Robertis, E.M.3
  • 46
    • 77952548279 scopus 로고    scopus 로고
    • Extracellular BMP-antagonist regulation in development and disease: tied up in knots
    • Walsh D.W., Godson C., Brazil D.P., Martin F. Extracellular BMP-antagonist regulation in development and disease: tied up in knots. Trends Cell Biol 2010, 20:244-256.
    • (2010) Trends Cell Biol , vol.20 , pp. 244-256
    • Walsh, D.W.1    Godson, C.2    Brazil, D.P.3    Martin, F.4
  • 47
    • 33744785946 scopus 로고    scopus 로고
    • Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro
    • Zhu W., Kim J., Cheng C., Rawlins B.A., Boachie-Adjei O., Crystal R.G., et al. Noggin regulation of bone morphogenetic protein (BMP) 2/7 heterodimer activity in vitro. Bone 2006, 39:61-71.
    • (2006) Bone , vol.39 , pp. 61-71
    • Zhu, W.1    Kim, J.2    Cheng, C.3    Rawlins, B.A.4    Boachie-Adjei, O.5    Crystal, R.G.6
  • 48
    • 0030598867 scopus 로고    scopus 로고
    • Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4
    • Piccolo S., Sasai Y., Lu B., De Robertis E.M. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 1996, 86:589-598.
    • (1996) Cell , vol.86 , pp. 589-598
    • Piccolo, S.1    Sasai, Y.2    Lu, B.3    De Robertis, E.M.4
  • 49
    • 0037119452 scopus 로고    scopus 로고
    • Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts
    • Shen Z.J., Nakamoto T., Tsuji K., Nifuji A., Miyazono K., Komori T., et al. Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts. J Biol Chem 2002, 277:29840-29846.
    • (2002) J Biol Chem , vol.277 , pp. 29840-29846
    • Shen, Z.J.1    Nakamoto, T.2    Tsuji, K.3    Nifuji, A.4    Miyazono, K.5    Komori, T.6
  • 50
    • 0028170038 scopus 로고
    • Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo
    • Graff J.M., Thies R.S., Song J.J., Celeste A.J., Melton D.A. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 1994, 79:169-179.
    • (1994) Cell , vol.79 , pp. 169-179
    • Graff, J.M.1    Thies, R.S.2    Song, J.J.3    Celeste, A.J.4    Melton, D.A.5
  • 51
    • 0032475884 scopus 로고    scopus 로고
    • Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
    • Macias-Silva M., Hoodless P.A., Tang S.J., Buchwald M., Wrana J.L. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J Biol Chem 1998, 273:25628-25636.
    • (1998) J Biol Chem , vol.273 , pp. 25628-25636
    • Macias-Silva, M.1    Hoodless, P.A.2    Tang, S.J.3    Buchwald, M.4    Wrana, J.L.5
  • 52
    • 67349187409 scopus 로고    scopus 로고
    • Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis
    • Little S.C., Mullins M.C. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat Cell Biol 2009, 11:637-643.
    • (2009) Nat Cell Biol , vol.11 , pp. 637-643
    • Little, S.C.1    Mullins, M.C.2
  • 53
    • 32244437156 scopus 로고    scopus 로고
    • Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing
    • O'Connor M.B., Umulis D., Othmer H.G., Blair S.S. Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing. Development 2006, 133:183-193.
    • (2006) Development , vol.133 , pp. 183-193
    • O'Connor, M.B.1    Umulis, D.2    Othmer, H.G.3    Blair, S.S.4
  • 54
    • 0032979875 scopus 로고    scopus 로고
    • Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers
    • Newfeld S.J., Wisotzkey R.G., Kumar S. Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers. Genetics 1999, 152:783-795.
    • (1999) Genetics , vol.152 , pp. 783-795
    • Newfeld, S.J.1    Wisotzkey, R.G.2    Kumar, S.3
  • 55
    • 1842863197 scopus 로고    scopus 로고
    • Regulation of BMP and activin signaling in Drosophila
    • Parker L., Stathakis D.G., Arora K. Regulation of BMP and activin signaling in Drosophila. Prog Mol Subcell Biol 2004, 34:73-101.
    • (2004) Prog Mol Subcell Biol , vol.34 , pp. 73-101
    • Parker, L.1    Stathakis, D.G.2    Arora, K.3
  • 56
    • 17644394929 scopus 로고    scopus 로고
    • Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo
    • Shimmi O., Umulis D., Othmer H., O'Connor M.B. Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. Cell 2005, 120:873-886.
    • (2005) Cell , vol.120 , pp. 873-886
    • Shimmi, O.1    Umulis, D.2    Othmer, H.3    O'Connor, M.B.4
  • 58
    • 0037409732 scopus 로고    scopus 로고
    • New synthetic biodegradable polymers as BMP carriers for bone tissue engineering
    • Saito N., Takaoka K. New synthetic biodegradable polymers as BMP carriers for bone tissue engineering. Biomaterials 2003, 24:2287-2293.
    • (2003) Biomaterials , vol.24 , pp. 2287-2293
    • Saito, N.1    Takaoka, K.2
  • 59
    • 34249889877 scopus 로고    scopus 로고
    • Review: mineralization of synthetic polymer scaffolds for bone tissue engineering
    • Kretlow J.D., Mikos A.G. Review: mineralization of synthetic polymer scaffolds for bone tissue engineering. Tissue Eng 2007, 13:927-938.
    • (2007) Tissue Eng , vol.13 , pp. 927-938
    • Kretlow, J.D.1    Mikos, A.G.2
  • 60
    • 0037439166 scopus 로고    scopus 로고
    • Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion
    • Silber J.S., Anderson D.G., Daffner S.D., Brislin B.T., Leland J.M., Hilibrand A.S., et al. Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine 2003, 28:134-139.
    • (2003) Spine , vol.28 , pp. 134-139
    • Silber, J.S.1    Anderson, D.G.2    Daffner, S.D.3    Brislin, B.T.4    Leland, J.M.5    Hilibrand, A.S.6
  • 61
    • 0036524009 scopus 로고    scopus 로고
    • Persistent iliac crest donor site pain: independent outcome assessment
    • discussion 6-7
    • Heary R.F., Schlenk R.P., Sacchieri T.A., Barone D., Brotea C. Persistent iliac crest donor site pain: independent outcome assessment. Neurosurgery 2002, 50:510-516. discussion 6-7.
    • (2002) Neurosurgery , vol.50 , pp. 510-516
    • Heary, R.F.1    Schlenk, R.P.2    Sacchieri, T.A.3    Barone, D.4    Brotea, C.5
  • 62
    • 0016166324 scopus 로고
    • Membranous vs endochondrial bone autografts
    • Smith J.D., Abramson M. Membranous vs endochondrial bone autografts. Arch Otolaryngol 1974, 99:203-205.
    • (1974) Arch Otolaryngol , vol.99 , pp. 203-205
    • Smith, J.D.1    Abramson, M.2
  • 64
    • 33947321905 scopus 로고    scopus 로고
    • Synthetic bone scaffolds and fracture repair
    • Carson J.S., Bostrom M.P. Synthetic bone scaffolds and fracture repair. Injury 2007, 38(Suppl. 1):S33-S37.
    • (2007) Injury , vol.38 , Issue.SUPPL. 1
    • Carson, J.S.1    Bostrom, M.P.2
  • 66
    • 0036894554 scopus 로고    scopus 로고
    • Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies
    • Boden S.D., Kang J., Sandhu H., Heller J.G. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine 2002, 27:2662-2673.
    • (2002) Spine , vol.27 , pp. 2662-2673
    • Boden, S.D.1    Kang, J.2    Sandhu, H.3    Heller, J.G.4
  • 67
    • 79955022472 scopus 로고    scopus 로고
    • High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo
    • Zara J.N., Siu R.K., Zhang X., Shen J., Ngo R., Lee M., et al. High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. Tissue Eng A 2011, 17:1389-1399.
    • (2011) Tissue Eng A , vol.17 , pp. 1389-1399
    • Zara, J.N.1    Siu, R.K.2    Zhang, X.3    Shen, J.4    Ngo, R.5    Lee, M.6
  • 68
    • 0033800431 scopus 로고    scopus 로고
    • Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts
    • Kaneko H., Arakawa T., Mano H., Kaneda T., Ogasawara A., Nakagawa M., et al. Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts. Bone 2000, 27:479-486.
    • (2000) Bone , vol.27 , pp. 479-486
    • Kaneko, H.1    Arakawa, T.2    Mano, H.3    Kaneda, T.4    Ogasawara, A.5    Nakagawa, M.6
  • 69
    • 0032992531 scopus 로고    scopus 로고
    • Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model
    • Uludag H., D'Augusta D., Palmer R., Timony G., Wozney J. Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model. J Biomed Mater Res 1999, 46:193-202.
    • (1999) J Biomed Mater Res , vol.46 , pp. 193-202
    • Uludag, H.1    D'Augusta, D.2    Palmer, R.3    Timony, G.4    Wozney, J.5
  • 70
    • 77957190145 scopus 로고    scopus 로고
    • Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells when BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone
    • Carpenter R.S., Goodrich L.R., Frisbie D.D., Kisiday J.D., Carbone B., McIlwraith C.W., et al. Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells when BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone. J Orthop Res 2010, 28:1330-1337.
    • (2010) J Orthop Res , vol.28 , pp. 1330-1337
    • Carpenter, R.S.1    Goodrich, L.R.2    Frisbie, D.D.3    Kisiday, J.D.4    Carbone, B.5    McIlwraith, C.W.6
  • 71
    • 84857869168 scopus 로고    scopus 로고
    • BMP2/7 heterodimer can modulate all cellular events of the in vitro RANKL-mediated osteoclastogenesis respectively in different dose-patterns
    • Zheng Y., Wang L., Zhang X., Gu Z., Wu G. BMP2/7 heterodimer can modulate all cellular events of the in vitro RANKL-mediated osteoclastogenesis respectively in different dose-patterns. Tissue Eng A 2012, 18(5-6):621-630.
    • (2012) Tissue Eng A , vol.18 , Issue.5-6 , pp. 621-630
    • Zheng, Y.1    Wang, L.2    Zhang, X.3    Gu, Z.4    Wu, G.5
  • 72
    • 83555164707 scopus 로고    scopus 로고
    • Low-dose rhBMP2/7 heterodimer to reconstruct peri-implant bone defects: a micro-CT evaluation
    • Wang J., Zheng Y., Zhao J., Liu T., Gao L., Gu Z., et al. Low-dose rhBMP2/7 heterodimer to reconstruct peri-implant bone defects: a micro-CT evaluation. J Clin Periodontol 2012, 39:98-105.
    • (2012) J Clin Periodontol , vol.39 , pp. 98-105
    • Wang, J.1    Zheng, Y.2    Zhao, J.3    Liu, T.4    Gao, L.5    Gu, Z.6
  • 73
    • 77953590859 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis?
    • Alarmo E.L., Kallioniemi A. Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis?. Endocr Relat Cancer 2010, 17:R123-R139.
    • (2010) Endocr Relat Cancer , vol.17
    • Alarmo, E.L.1    Kallioniemi, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.