Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice

Development (Cambridge)

Volumn 141, Issue 15, 2014, Pages 3062-3071

  Tilak, Anup ^a   Nelsen, Sylvia M ^a   Kim, Hyung Seok ^b   Donley, Nathan ^a   McKnite, Autumn ^b   Lee, Hyunjung ^a   Christian, Jan L ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Bone morphogenetic protein 4; Prodomain; Proprotein convertase

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; OSTEOGENIC PROTEIN 1;

ALLELE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CHEMICAL ANALYSIS; EMBRYO; EMBRYO DEVELOPMENT; GAIN OF FUNCTION MUTATION; GENE TARGETING; HETEROZYGOTE; HOMOZYGOTE; IN VIVO STUDY; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

BONE MORPHOGENETIC PROTEIN 4; PRODOMAIN; PROPROTEIN CONVERTASE;

ALLELES; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; BODY PATTERNING; BONE MORPHOGENETIC PROTEIN 4; CROSSES, GENETIC; HEK293 CELLS; HUMANS; LIGANDS; MICE; MUTATION; PHENOTYPE; PROTEIN BINDING; SIGNAL TRANSDUCTION; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 84904610131     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.110130     Document Type: Article

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