Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity

Development

Volumn 133, Issue 10, 2006, Pages 1933-1942

  Goldman, Devorah C ^a   Hackenmiller, Renee ^a   Nakayama, Takuya ^a,b   Sopory, Shailaja ^a   Wong, Crispin ^a   Kulessa, Holger ^c   Christian, Jan L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bone morphogenetic protein; Cleavage mutant mouse; Embryonic patterning; Proprotein convertase; Proteolytic activation

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4;

ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; EMBRYO DEVELOPMENT; EYE MALFORMATION; FETUS MEMBRANE; GENETIC ANALYSIS; GERM CELL; HAPLOTYPE; HEART DISEASE; HUMAN; HUMAN CELL; KIDNEY DEVELOPMENT; LETHALITY; LIMB DEVELOPMENT; MOUSE; NONHUMAN; PERINATAL PERIOD; PLACENTA CIRCULATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; SENSITIVITY ANALYSIS; TESTIS; TISSUE SPECIFICITY; VERTEBRA;

ANIMALS; BONE MORPHOGENETIC PROTEINS; EMBRYONIC DEVELOPMENT; GENE DOSAGE; GENE TARGETING; GERM CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; ORGAN SPECIFICITY; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; TESTIS;

EID: 33745094372     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.02368     Document Type: Article

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