Insulin reverses D-glucose-increased nitric oxide and reactive oxygen species generation in human umbilical vein endothelial cells

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  González, Marcelo ^a,c   Rojas, Susana ^a   Avila, Pía ^a   Cabrera, Lissette ^a,b   Villalobos, Roberto ^g   Palma, Carlos ^a   Aguayo, Claudio ^a,c   Peña, Eduardo ^a   Gallardo, Victoria ^a   Guzmán Gutiérrez, Enrique ^c,d   Sáez, Tamara ^g   Salsoso, Rocío ^g   Sanhueza, Carlos ^g   Pardo, Fabián ^g   Leiva, Andrea ^g   Sobrevia, Luis ^e,f,g  

^a UNIVERSITY OF CONCEPCIÓN   (Chile)

^b UNIVERSIDAD DIEGO PORTALES   (Chile)

^c Group of Research and Innovation in Vascular Health (GRIVAS Health)   (Chile)

^d UNIVERSIDAD SAN SEBASTIÁN   (Chile)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f UNIVERSITY OF SEVILLE   (Spain)

^g PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; AMINO ACID TRANSPORTER; APOCYNIN; ARGININE; CALCITONIN GENE RELATED PEPTIDE; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TEMPOL; TETRAHYDROBIOPTERIN; ACETOPHENONE DERIVATIVE; AMINE OXIDE; BIOPTERIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN; P44 PROTEIN, HUMAN; SAPROPTERIN; SLC7A1 PROTEIN, HUMAN; SPIN LABEL; TRANSCRIPTION FACTOR; VASOCONSTRICTOR AGENT;

AMINO ACID TRANSPORT; ARTICLE; BIOSYNTHESIS; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MYOGRAPHY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING; AGONISTS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUE; UMBILICAL VEIN;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACETOPHENONES; ARGININE; BIOPTERIN; CALCITONIN GENE-RELATED PEPTIDE; CATIONIC AMINO ACID TRANSPORTER 1; CYCLIC N-OXIDES; GENE EXPRESSION REGULATION; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INSULIN; MITOGEN-ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPIN LABELS; TISSUE CULTURE TECHNIQUES; TRANSCRIPTION FACTORS; UMBILICAL VEINS; VASOCONSTRICTOR AGENTS;

EID: 84928910946     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122398     Document Type: Article

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