메뉴 건너뛰기




Volumn 414, Issue 4, 2011, Pages 660-663

Intracellular l-arginine concentration does not determine NO production in endothelial cells: Implications on the " l-arginine paradox"

Author keywords

Asymmetric dimethylarginine; L Arginine; L Arginine paradox; L Arginine transport; Nitric oxide

Indexed keywords

ARGININE; ARGININE ETHYL ESTER; CITRULLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRATE; NITRIC OXIDE; NITRITE; NITROGEN 15; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 80555130991     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.112     Document Type: Article
Times cited : (54)

References (21)
  • 1
  • 2
    • 0023912670 scopus 로고
    • Vascular endothelial cells synthesize nitric oxide from l-arginine
    • Palmer R.M., Ashton D.S., Moncada S. Vascular endothelial cells synthesize nitric oxide from l-arginine. Nature 1988, 333:664-666.
    • (1988) Nature , vol.333 , pp. 664-666
    • Palmer, R.M.1    Ashton, D.S.2    Moncada, S.3
  • 3
    • 0025540554 scopus 로고
    • Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells
    • Baydoun A.R., Emery P.W., Pearson J.D., Mann G.E. Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells. Biochemical and Biophysical Research Communications 1990, 173:940-948.
    • (1990) Biochemical and Biophysical Research Communications , vol.173 , pp. 940-948
    • Baydoun, A.R.1    Emery, P.W.2    Pearson, J.D.3    Mann, G.E.4
  • 6
    • 11144278269 scopus 로고    scopus 로고
    • An oral yohimbine/l-arginine combination (NMI 861) for the treatment of male erectile dysfunction: a pharmacokinetic pharmacodynamic and interaction study with intravenous nitroglycerine in healthy male subjects
    • Kernohan A.F., McIntyre M., Hughes D.M., Tam S.W., Worcel M., Reid J.L. An oral yohimbine/l-arginine combination (NMI 861) for the treatment of male erectile dysfunction: a pharmacokinetic pharmacodynamic and interaction study with intravenous nitroglycerine in healthy male subjects. British Journal of Clinical Pharmacology 2005, 59:85-93.
    • (2005) British Journal of Clinical Pharmacology , vol.59 , pp. 85-93
    • Kernohan, A.F.1    McIntyre, M.2    Hughes, D.M.3    Tam, S.W.4    Worcel, M.5    Reid, J.L.6
  • 8
    • 0032472847 scopus 로고    scopus 로고
    • Characterization of l-arginine uptake by plasma membrane vesicles isolated from cultured pulmonary artery endothelial cells
    • Zharikov S.I., Block E.R. Characterization of l-arginine uptake by plasma membrane vesicles isolated from cultured pulmonary artery endothelial cells. Biochimica et Biophysica Acta 1998, 1369:173-183.
    • (1998) Biochimica et Biophysica Acta , vol.1369 , pp. 173-183
    • Zharikov, S.I.1    Block, E.R.2
  • 9
    • 0031452440 scopus 로고    scopus 로고
    • A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the " arginine paradox"
    • McDonald K.K., Zharikov S., Block E.R., Kilberg M.S. A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the " arginine paradox" Journal of Biological Chemistry 1997, 272:31213-31216.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 31213-31216
    • McDonald, K.K.1    Zharikov, S.2    Block, E.R.3    Kilberg, M.S.4
  • 10
    • 0037081491 scopus 로고    scopus 로고
    • Coordinate regulation of l-arginine uptake and nitric oxide synthase activity in cultured endothelial cells
    • Hardy T.A., May J.M. Coordinate regulation of l-arginine uptake and nitric oxide synthase activity in cultured endothelial cells. Free Radical Biology and Medicine 2002, 32:122-131.
    • (2002) Free Radical Biology and Medicine , vol.32 , pp. 122-131
    • Hardy, T.A.1    May, J.M.2
  • 11
    • 25444432236 scopus 로고    scopus 로고
    • Transport of extracellular l-arginine via cationic amino acid transporter is required during in vivo endothelial nitric oxide production
    • Zani B.G., Bohlen H.G. Transport of extracellular l-arginine via cationic amino acid transporter is required during in vivo endothelial nitric oxide production. American Journal of Physiology - Heart and Circulatory Physiology 2005, 289:H1381-1390.
    • (2005) American Journal of Physiology - Heart and Circulatory Physiology , vol.289
    • Zani, B.G.1    Bohlen, H.G.2
  • 16
    • 80555145443 scopus 로고    scopus 로고
    • l-Arginine Transport, Metabolism and Action, Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo
    • S. Shin, l-Arginine Transport, Metabolism and Action, Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, 2011.
    • (2011)
    • Shin, S.1
  • 18
    • 80555131350 scopus 로고    scopus 로고
    • Role of asymmetric dimethylarginine in l-arginine paradox: transport and metabolism considerations
    • abstract #1103., AAPS Annual Meeting and Exposition,
    • S. Shin, H.-L. Fung, Role of asymmetric dimethylarginine in l-arginine paradox: transport and metabolism considerations, in: AAPS Annual Meeting and Exposition, The AAPS Journal, 2009, abstract #1103.
    • (2009) The AAPS Journal
    • Shin, S.1    Fung, H.-L.2
  • 19
    • 34249706763 scopus 로고    scopus 로고
    • The l-arginine paradox: importance of the l-arginine/asymmetrical dimethylarginine ratio
    • Bode-Boger S.M., Scalera F., Ignarro L.J. The l-arginine paradox: importance of the l-arginine/asymmetrical dimethylarginine ratio. Pharmacology and Therapeutics 2007, 114:295-306.
    • (2007) Pharmacology and Therapeutics , vol.114 , pp. 295-306
    • Bode-Boger, S.M.1    Scalera, F.2    Ignarro, L.J.3
  • 20
    • 80555131347 scopus 로고    scopus 로고
    • Extracellular l-arginine transport, not its intracellular concentration, determines l-arginine action in endothelial cells
    • 2010 FIP Pharmaceutical Sciences World Congress,
    • S. Shin, H.-L. Fung, Extracellular l-arginine transport, not its intracellular concentration, determines l-arginine action in endothelial cells, in: 2010 FIP Pharmaceutical Sciences World Congress, The AAPS Journal, 2010, pp. T3392.
    • (2010) The AAPS Journal
    • Shin, S.1    Fung, H.-L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.