-
1
-
-
33644544089
-
Empirical antibacterial drug discovery - Foundation in natural products
-
Singh, S.B.; Barrett, J.F. Empirical antibacterial drug discovery - Foundation in natural products. Biochem. Pharmacol. 2006, 71, 1006-1015.
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 1006-1015
-
-
Singh, S.B.1
Barrett, J.F.2
-
2
-
-
3543093192
-
Producing penicillin
-
Lerner, P.I. Producing penicillin. N. Engl. J. Med. 2004, 351, 524.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 524
-
-
Lerner, P.I.1
-
3
-
-
84921033730
-
Clinical, economic and societal impact of antibiotic resistance
-
Barriere, S.L. Clinical, economic and societal impact of antibiotic resistance. Expert Opin. Pharmacother. 2015, 16, 151-153.
-
(2015)
Expert Opin. Pharmacother.
, vol.16
, pp. 151-153
-
-
Barriere, S.L.1
-
4
-
-
26444491047
-
Resistance to antibiotics: Are we in the post-antibiotic era?
-
Alanis, A.J. Resistance to antibiotics: Are we in the post-antibiotic era? Arch. Med. Res. 2005, 36, 697-705.
-
(2005)
Arch. Med. Res.
, vol.36
, pp. 697-705
-
-
Alanis, A.J.1
-
6
-
-
57549114267
-
The sociobiology of biofilms
-
Nadell, C.D.; Xavier, J.B.; Foster, K.R. The sociobiology of biofilms. FEMS Microbiol. Rev. 2009, 33, 206-224.
-
(2009)
FEMS Microbiol. Rev.
, vol.33
, pp. 206-224
-
-
Nadell, C.D.1
Xavier, J.B.2
Foster, K.R.3
-
7
-
-
33644517930
-
Bacterial small-molecule signaling pathways
-
Camilli, A.; Bassler, B.L. Bacterial small-molecule signaling pathways. Science 2006, 311, 1113-1116.
-
(2006)
Science
, vol.311
, pp. 1113-1116
-
-
Camilli, A.1
Bassler, B.L.2
-
9
-
-
0032173598
-
Multiple antibiotic resistance and efflux
-
Nikaido, H. Multiple antibiotic resistance and efflux. Curr. Opin. Microbiol. 1998, 1, 516-523.
-
(1998)
Curr. Opin. Microbiol.
, vol.1
, pp. 516-523
-
-
Nikaido, H.1
-
10
-
-
0242291983
-
Multidrug efflux pumps and resistance: Regulation and evolution
-
Paulsen, I.T. Multidrug efflux pumps and resistance: Regulation and evolution. Curr. Opin. Microbiol. 2003, 6, 446-451.
-
(2003)
Curr. Opin. Microbiol.
, vol.6
, pp. 446-451
-
-
Paulsen, I.T.1
-
11
-
-
84923081620
-
What is a resistance gene? Ranking risk in resistomes
-
Martinez, J.L.; Coque, T.M.; Baquero, F. What is a resistance gene? Ranking risk in resistomes. Nat. Rev. Microbiol. 2015, 13, 116-123.
-
(2015)
Nat. Rev. Microbiol.
, vol.13
, pp. 116-123
-
-
Martinez, J.L.1
Coque, T.M.2
Baquero, F.3
-
12
-
-
84920168694
-
Forces shaping the antibiotic resistome
-
Perry, J.A.; Wright, G.D. Forces shaping the antibiotic resistome. Bioessays 2014, 36, 1179-1184.
-
(2014)
Bioessays
, vol.36
, pp. 1179-1184
-
-
Perry, J.A.1
Wright, G.D.2
-
13
-
-
31144458334
-
Sampling the antibiotic resistome
-
D'Costa, V.M.; McGrann, K.M.; Hughes, D.W.; Wright, G.D. Sampling the antibiotic resistome. Science 2006, 311, 374-377.
-
(2006)
Science
, vol.311
, pp. 374-377
-
-
D'Costa, V.M.1
McGrann, K.M.2
Hughes, D.W.3
Wright, G.D.4
-
14
-
-
69549086653
-
Functional characterization of the antibiotic resistance reservoir in the human microflora
-
Sommer, M.O.A.; Dantas, G.; Church, G.M. Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 2009, 325, 1128-1131.
-
(2009)
Science
, vol.325
, pp. 1128-1131
-
-
Sommer, M.O.A.1
Dantas, G.2
Church, G.M.3
-
15
-
-
33847151750
-
The antibiotic resistome: The nexus of chemical and genetic diversity
-
Wright, G.D. The antibiotic resistome: The nexus of chemical and genetic diversity. Nat. Rev. Microbiol. 2007, 5, 175-186.
-
(2007)
Nat. Rev. Microbiol.
, vol.5
, pp. 175-186
-
-
Wright, G.D.1
-
16
-
-
77957820588
-
Antibiotic resistance in the environment: A link to the clinic?
-
Wright, G.D. Antibiotic resistance in the environment: A link to the clinic? Curr. Opin. Microbiol. 2010, 13, 589-594.
-
(2010)
Curr. Opin. Microbiol.
, vol.13
, pp. 589-594
-
-
Wright, G.D.1
-
17
-
-
84875825656
-
Evolutionary consequences of antibiotic use for the resistome, mobilome, and microbial pangenome
-
Gillings, M.R. Evolutionary consequences of antibiotic use for the resistome, mobilome, and microbial pangenome. Front. Microbiol. 2013, 4, doi:10.3389/fmicb.2013.00004.
-
(2013)
Front. Microbiol.
, vol.4
-
-
Gillings, M.R.1
-
18
-
-
62549092624
-
Antibiotic resistance in bacteria isolated from the deep terrestrial subsurface
-
Brown, M.G.; Balkwill, D.L. Antibiotic resistance in bacteria isolated from the deep terrestrial subsurface. Microb. Ecol. 2009, 57, 484-493.
-
(2009)
Microb. Ecol.
, vol.57
, pp. 484-493
-
-
Brown, M.G.1
Balkwill, D.L.2
-
19
-
-
0346500434
-
Phylogenetic and physiological diversity of microorganisms isolated from a deep greenland glacier ice core
-
Miteva, V.I.; Sheridan, P.P.; Brenchley, J.E. Phylogenetic and physiological diversity of microorganisms isolated from a deep greenland glacier ice core. Appl. Environ. Microbiol. 2004, 70, 202-213.
-
(2004)
Appl. Environ. Microbiol.
, vol.70
, pp. 202-213
-
-
Miteva, V.I.1
Sheridan, P.P.2
Brenchley, J.E.3
-
20
-
-
80053130409
-
Antibiotic resistance is ancient
-
D'Costa, V.M.; King, C.E.; Kalan, L.; Morar, M.; Sung, W.W.L.; Schwarz, C.; Froese, D.; Zazula, G.; Calmels, F.; Debruyne, R.; et al. Antibiotic resistance is ancient. Nature 2011, 477, 457-461.
-
(2011)
Nature
, vol.477
, pp. 457-461
-
-
D'Costa, V.M.1
King, C.E.2
Kalan, L.3
Morar, M.4
Sung, W.W.L.5
Schwarz, C.6
Froese, D.7
Zazula, G.8
Calmels, F.9
Debruyne, R.10
-
21
-
-
0029845047
-
Proton-dependent multidrug efflux systems
-
Paulsen, I.T.; Brown, M.H.; Skurray, R.A. Proton-dependent multidrug efflux systems. Microbiol. Rev. 1996, 60, 575-608.
-
(1996)
Microbiol. Rev.
, vol.60
, pp. 575-608
-
-
Paulsen, I.T.1
Brown, M.H.2
Skurray, R.A.3
-
22
-
-
84887460917
-
Antibiotic resistance: Origins, mechanisms, approaches to counter
-
Debabov, D. Antibiotic resistance: Origins, mechanisms, approaches to counter. Appl. Biochem. Microbiol. 2013, 49, 665-671.
-
(2013)
Appl. Biochem. Microbiol.
, vol.49
, pp. 665-671
-
-
Debabov, D.1
-
23
-
-
0032908465
-
The calgary biofilm device: New technology for rapid determination of antibiotic susceptibilities of bacterial biofilms
-
Ceri, H.; Olson, M.E.; Stremick, C.; Read, R.R.; Morck, D.; Buret, A. The calgary biofilm device: New technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J. Clin. Microbiol. 1999, 37, 1771-1776.
-
(1999)
J. Clin. Microbiol.
, vol.37
, pp. 1771-1776
-
-
Ceri, H.1
Olson, M.E.2
Stremick, C.3
Read, R.R.4
Morck, D.5
Buret, A.6
-
24
-
-
76649143766
-
Amyloid fibers provide structural integrity to Bacillus subtilis biofilms
-
Romero, D.; Aguilar, C.; Losick, R.; Kolter, R. Amyloid fibers provide structural integrity to Bacillus subtilis biofilms. Proc. Natl. Acad. Sci. USA 2010, 107, 2230-2234.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 2230-2234
-
-
Romero, D.1
Aguilar, C.2
Losick, R.3
Kolter, R.4
-
25
-
-
0037154837
-
Extracellular DNA required for bacterial biofilm formation
-
Whitchurch, C.B.; Tolker-Nielsen, T.; Ragas, P.C.; Mattick, J.S. Extracellular DNA required for bacterial biofilm formation. Science 2002, 295, 1487.
-
(2002)
Science
, vol.295
, pp. 1487
-
-
Whitchurch, C.B.1
Tolker-Nielsen, T.2
Ragas, P.C.3
Mattick, J.S.4
-
26
-
-
84887628130
-
Bacterial biofilm development as a multicellular adaptation: Antibiotic resistance and new therapeutic strategies
-
De la Fuente-Núñez, C.; Reffuveille, F.; Fernández, L.; Hancock, R.E.W. Bacterial biofilm development as a multicellular adaptation: Antibiotic resistance and new therapeutic strategies. Curr. Opin. Microbiol. 2013, 16, 580-589.
-
(2013)
Curr. Opin. Microbiol.
, vol.16
, pp. 580-589
-
-
De La Fuente-Núñez, C.1
Reffuveille, F.2
Fernández, L.3
Hancock, R.E.W.4
-
27
-
-
0028866136
-
Microbial biofilms
-
Costerton, J.W.; Lewandowski, Z.; Caldwell, D.E.; Korber, D.R.; Lappin-Scott, H.M. Microbial biofilms. Annu. Rev. Microbiol. 1995, 49, 711-745.
-
(1995)
Annu. Rev. Microbiol.
, vol.49
, pp. 711-745
-
-
Costerton, J.W.1
Lewandowski, Z.2
Caldwell, D.E.3
Korber, D.R.4
Lappin-Scott, H.M.5
-
28
-
-
0033591467
-
Bacterial biofilms: A common cause of persistent infections
-
Costerton, J.W.; Stewart, P.S.; Greenberg, E.P. Bacterial biofilms: A common cause of persistent infections. Science 1999, 284, 1318-1322.
-
(1999)
Science
, vol.284
, pp. 1318-1322
-
-
Costerton, J.W.1
Stewart, P.S.2
Greenberg, E.P.3
-
29
-
-
79953165038
-
Aminoglycoside resistance of Pseudomonas aeruginosa biofilms modulated by extracellular polysaccharide
-
Khan, W.; Bernier, S.P.; Kuchma, S.L.; Hammond, J.H.; Hasan, F.; O'Toole, G.A. Aminoglycoside resistance of Pseudomonas aeruginosa biofilms modulated by extracellular polysaccharide. Int. Microbiol. 2010, 13, 207-212.
-
(2010)
Int. Microbiol.
, vol.13
, pp. 207-212
-
-
Khan, W.1
Bernier, S.P.2
Kuchma, S.L.3
Hammond, J.H.4
Hasan, F.5
O'Toole, G.A.6
-
30
-
-
79959836714
-
Distinct roles of extracellular polymeric substances in Pseudomonas aeruginosa biofilm development
-
Yang, L.; Hu, Y.; Liu, Y.; Zhang, J.; Ulstrup, J.; Molin, S. Distinct roles of extracellular polymeric substances in Pseudomonas aeruginosa biofilm development. Environ. Microbiol. 2011, 13, 1705-1717.
-
(2011)
Environ. Microbiol.
, vol.13
, pp. 1705-1717
-
-
Yang, L.1
Hu, Y.2
Liu, Y.3
Zhang, J.4
Ulstrup, J.5
Molin, S.6
-
31
-
-
57149111485
-
Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms
-
Mulcahy, H.; Charron-Mazenod, L.; Lewenza, S. Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms. PLoS Pathog. 2008, 4, e1000213.
-
(2008)
PLoS Pathog.
, vol.4
, pp. e1000213
-
-
Mulcahy, H.1
Charron-Mazenod, L.2
Lewenza, S.3
-
32
-
-
84876275584
-
Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms
-
Chiang, W.C.; Nilsson, M.; Jensen, P.O.; Høiby, N.; Nielsen, T.E.; Givskov, M.; Tolker-Nielsen, T. Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms. Antimicrob. Agents Chemother. 2013, 57, 2352-2361.
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 2352-2361
-
-
Chiang, W.C.1
Nilsson, M.2
Jensen, P.O.3
Høiby, N.4
Nielsen, T.E.5
Givskov, M.6
Tolker-Nielsen, T.7
-
33
-
-
81555212273
-
Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria
-
Nguyen, D.; Joshi-Datar, A.; Lepine, F.; Bauerle, E.; Olakanmi, O.; Beer, K.; McKay, G.; Siehnel, R.; Schafhauser, J.; Wang, Y.; et al. Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria. Science 2011, 334, 982-986.
-
(2011)
Science
, vol.334
, pp. 982-986
-
-
Nguyen, D.1
Joshi-Datar, A.2
Lepine, F.3
Bauerle, E.4
Olakanmi, O.5
Beer, K.6
McKay, G.7
Siehnel, R.8
Schafhauser, J.9
Wang, Y.10
-
34
-
-
84880084458
-
Biofilm-associated infections: Antibiotic resistance and novel therapeutic strategies
-
Sun, F.; Qu, F.; Ling, Y.; Mao, P.; Xia, P.; Chen, H.; Zhou, D. Biofilm-associated infections: Antibiotic resistance and novel therapeutic strategies. Future Microbiol. 2013, 8, 877-886.
-
(2013)
Future Microbiol.
, vol.8
, pp. 877-886
-
-
Sun, F.1
Qu, F.2
Ling, Y.3
Mao, P.4
Xia, P.5
Chen, H.6
Zhou, D.7
-
35
-
-
84873500633
-
Starvation, together with the sos response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin
-
Bernier, S.P.; Lebeaux, D.; DeFrancesco, A.S.; Valomon, A.; Soubigou, G.; Coppée, J.Y.; Ghigo, J.M.; Beloin, C. Starvation, together with the sos response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin. PLoS Genet. 2013, 9, e1003144.
-
(2013)
PLoS Genet.
, vol.9
, pp. e1003144
-
-
Bernier, S.P.1
Lebeaux, D.2
DeFrancesco, A.S.3
Valomon, A.4
Soubigou, G.5
Coppée, J.Y.6
Ghigo, J.M.7
Beloin, C.8
-
36
-
-
45549104015
-
Multidrug tolerance of biofilms and persister cells
-
Lewis, K. Multidrug tolerance of biofilms and persister cells. Curr. Top. Microbiol. Immunol. 2008, 322, 107-131.
-
(2008)
Curr. Top. Microbiol. Immunol.
, vol.322
, pp. 107-131
-
-
Lewis, K.1
-
37
-
-
77957947243
-
Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis
-
Mulcahy, L.R.; Burns, J.L.; Lory, S.; Lewis, K. Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. J. Bacteriol. 2010, 192, 6191-6199.
-
(2010)
J. Bacteriol.
, vol.192
, pp. 6191-6199
-
-
Mulcahy, L.R.1
Burns, J.L.2
Lory, S.3
Lewis, K.4
-
38
-
-
84907879368
-
Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations
-
Fridman, O.; Goldberg, A.; Ronin, I.; Shoresh, N.; Balaban, N.Q. Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations. Nature 2014, 513, 418-421.
-
(2014)
Nature
, vol.513
, pp. 418-421
-
-
Fridman, O.1
Goldberg, A.2
Ronin, I.3
Shoresh, N.4
Balaban, N.Q.5
-
39
-
-
67650924526
-
Role of mutation in Pseudomonas aeruginosa biofilm development
-
Conibear, T.C.R.; Collins, S.L.; Webb, J.S. Role of mutation in Pseudomonas aeruginosa biofilm development. PLoS One 2009, 4, e6289.
-
(2009)
PLoS One
, vol.4
, pp. e6289
-
-
Conibear, T.C.R.1
Collins, S.L.2
Webb, J.S.3
-
40
-
-
0242407416
-
Hypermutation as a factor contributing to the acquisition of antimicrobial resistance
-
Blázquez, J. Hypermutation as a factor contributing to the acquisition of antimicrobial resistance. Clin. Infect. Dis. 2003, 37, 1201-1209.
-
(2003)
Clin. Infect. Dis.
, vol.37
, pp. 1201-1209
-
-
Blázquez, J.1
-
41
-
-
23044473638
-
Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections
-
Macía, M.D.; Blanquer, D.; Togores, B.; Sauleda, J.; Pérez, J.L.; Oliver, A. Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections. Antimicrob. Agents Chemother. 2005, 49, 3382-3386.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 3382-3386
-
-
Macía, M.D.1
Blanquer, D.2
Togores, B.3
Sauleda, J.4
Pérez, J.L.5
Oliver, A.6
-
42
-
-
0038192446
-
Horizontal acquisition of divergent chromosomal DNA in bacteria: Effects of mutator phenotypes
-
Townsend, J.P.; Nielsen, K.M.; Fishert, D.S.; Hartl, D.L. Horizontal acquisition of divergent chromosomal DNA in bacteria: Effects of mutator phenotypes. Genetics 2003, 164, 13-21.
-
(2003)
Genetics
, vol.164
, pp. 13-21
-
-
Townsend, J.P.1
Nielsen, K.M.2
Fishert, D.S.3
Hartl, D.L.4
-
43
-
-
84876341713
-
Biofilms: The secret story of microbial communities
-
Locht, C., Simonet, M., Eds.; Caister Academic Press: Norfolk, UK
-
Bernard, C.S.; Giraud, C.; Spagnolo, J.; de Bentzmann, S. Biofilms: The secret story of microbial communities. In Bacterial Pathogenesis: Molecular and Cellular Mechanisms; Locht, C., Simonet, M., Eds.; Caister Academic Press: Norfolk, UK, 2012; pp. 129-168.
-
(2012)
Bacterial Pathogenesis: Molecular and Cellular Mechanisms
, pp. 129-168
-
-
Bernard, C.S.1
Giraud, C.2
Spagnolo, J.3
De Bentzmann, S.4
-
44
-
-
67649230578
-
Evidence for dynamic exchange of qac gene cassettes between class 1 integrons and other integrons in freshwater biofilms
-
Gillings, M.R.; Holley, M.P.; Stokes, H.W. Evidence for dynamic exchange of qac gene cassettes between class 1 integrons and other integrons in freshwater biofilms. FEMS Microbiol. Lett. 2009, 296, 282-288.
-
(2009)
FEMS Microbiol. Lett.
, vol.296
, pp. 282-288
-
-
Gillings, M.R.1
Holley, M.P.2
Stokes, H.W.3
-
45
-
-
79956277237
-
Coral-mucus-associated vibrio integrons in the great barrier reef: Genomic hotspots for environmental adaptation
-
Koenig, J.E.; Bourne, D.G.; Curtis, B.; Dlutek, M.; Stokes, H.W.; Doolittle, W.F.; Boucher, Y. Coral-mucus-associated vibrio integrons in the great barrier reef: Genomic hotspots for environmental adaptation. ISME J. 2011, 5, 962-972.
-
(2011)
ISME J.
, vol.5
, pp. 962-972
-
-
Koenig, J.E.1
Bourne, D.G.2
Curtis, B.3
Dlutek, M.4
Stokes, H.W.5
Doolittle, W.F.6
Boucher, Y.7
-
46
-
-
79956048989
-
Aquatic systems: Maintaining, mixing and mobilising antimicrobial resistance?
-
Taylor, N.G.H.; Verner-Jeffreys, D.W.; Baker-Austin, C. Aquatic systems: Maintaining, mixing and mobilising antimicrobial resistance? Trends Ecol. Evol. 2011, 26, 278-284.
-
(2011)
Trends Ecol. Evol.
, vol.26
, pp. 278-284
-
-
Taylor, N.G.H.1
Verner-Jeffreys, D.W.2
Baker-Austin, C.3
-
47
-
-
23944484031
-
Studying plasmid horizontal transfer in situ: A critical review
-
Sørensen, S.J.; Bailey, M.; Hansen, L.H.; Kroer, N.; Wuertz, S. Studying plasmid horizontal transfer in situ: A critical review. Nat. Rev. Microbiol. 2005, 3, 700-710.
-
(2005)
Nat. Rev. Microbiol.
, vol.3
, pp. 700-710
-
-
Sørensen, S.J.1
Bailey, M.2
Hansen, L.H.3
Kroer, N.4
Wuertz, S.5
-
48
-
-
78751527447
-
Networks of gene sharing among 329 proteobacterial genomes reveal differences in lateral gene transfer frequency at different phylogenetic depths
-
Kloesges, T.; Popa, O.; Martin, W.; Dagan, T. Networks of gene sharing among 329 proteobacterial genomes reveal differences in lateral gene transfer frequency at different phylogenetic depths. Mol. Biol. Evol. 2011, 28, 1057-1074.
-
(2011)
Mol. Biol. Evol.
, vol.28
, pp. 1057-1074
-
-
Kloesges, T.1
Popa, O.2
Martin, W.3
Dagan, T.4
-
49
-
-
84866172604
-
Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species
-
Domingues, S.; Harms, K.; Fricke, W.F.; Johnsen, P.J.; da Silva, G.J.; Nielsen, K.M. Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species. PLoS Pathog. 2012, 8, e1002837.
-
(2012)
PLoS Pathog.
, vol.8
, pp. e1002837
-
-
Domingues, S.1
Harms, K.2
Fricke, W.F.3
Johnsen, P.J.4
Da Silva, G.J.5
Nielsen, K.M.6
-
50
-
-
84861335957
-
Are humans increasing bacterial evolvability?
-
Gillings, M.R.; Stokes, H.W. Are humans increasing bacterial evolvability? Trends Ecol. Evol. 2012, 27, 346-352.
-
(2012)
Trends Ecol. Evol.
, vol.27
, pp. 346-352
-
-
Gillings, M.R.1
Stokes, H.W.2
-
51
-
-
84908363161
-
Microbiology of the anthropocene
-
Gillings, M.R.; Paulsen, I.T. Microbiology of the anthropocene. Anthropocene 2014. doi:10.1016/j.ancene.2014.06.004.
-
(2014)
Anthropocene
-
-
Gillings, M.R.1
Paulsen, I.T.2
-
52
-
-
46049083393
-
Involvement of a novel efflux system in biofilm-specific resistance to antibiotics
-
Zhang, L.; Mah, T.F. Involvement of a novel efflux system in biofilm-specific resistance to antibiotics. J. Bacteriol. 2008, 190, 4447-4452.
-
(2008)
J. Bacteriol.
, vol.190
, pp. 4447-4452
-
-
Zhang, L.1
Mah, T.F.2
-
53
-
-
34948892056
-
Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms
-
Lynch, S.V.; Dixon, L.; Benoit, M.R.; Brodie, E.L.; Keyhan, M.; Hu, P.; Ackerley, D.F.; Andersen, G.L.; Matin, A. Role of the rapA gene in controlling antibiotic resistance of Escherichia coli biofilms. Antimicrob. Agents Chemother. 2007, 51, 3650-3658.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 3650-3658
-
-
Lynch, S.V.1
Dixon, L.2
Benoit, M.R.3
Brodie, E.L.4
Keyhan, M.5
Hu, P.6
Ackerley, D.F.7
Andersen, G.L.8
Matin, A.9
-
54
-
-
84874118804
-
Antimicrobials, drug discovery, and genome mining
-
Scheffler, R.J.; Colmer, S.; Tynan, H.; Demain, A.L.; Gullo, V.P. Antimicrobials, drug discovery, and genome mining. Appl. Microbiol. Biotechnol. 2013, 97, 969-978.
-
(2013)
Appl. Microbiol. Biotechnol.
, vol.97
, pp. 969-978
-
-
Scheffler, R.J.1
Colmer, S.2
Tynan, H.3
Demain, A.L.4
Gullo, V.P.5
-
55
-
-
3442887705
-
The antibiotic pipeline - Challenges, costs, and values
-
Wenzel, R.P. The antibiotic pipeline - Challenges, costs, and values. N. Engl. J. Med. 2004, 351, 523-526.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 523-526
-
-
Wenzel, R.P.1
-
56
-
-
33845697060
-
Where have all the antibiotic patents gone?
-
Katz, M.L.; Mueller, L.V.; Polyakov, M.; Weinstock, S.F. Where have all the antibiotic patents gone? Nat. Biotechnol. 2006, 24, 1529-1531.
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 1529-1531
-
-
Katz, M.L.1
Mueller, L.V.2
Polyakov, M.3
Weinstock, S.F.4
-
58
-
-
41649102800
-
Whither antibacterial drug discovery?
-
Projan, S.J. Whither antibacterial drug discovery? Drug Discov. Today 2008, 13, 279-280.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 279-280
-
-
Projan, S.J.1
-
59
-
-
84892038180
-
Marine bacteria as a source of new antibiotics
-
Nova Science Publishers: Hauppauge, NY, USA
-
Egan, S.; Penesyan, A. Marine bacteria as a source of new antibiotics. In Bioactive Compounds: Types, Biological Activities and Health Effects; Nova Science Publishers: Hauppauge, NY, USA, 2012; pp. 381-412.
-
(2012)
Bioactive Compounds: Types, Biological Activities and Health Effects
, pp. 381-412
-
-
Egan, S.1
Penesyan, A.2
-
60
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
Payne, D.J.; Gwynn, M.N.; Holmes, D.J.; Pompliano, D.L. Drugs for bad bugs: Confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 2007, 6, 29-40.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
61
-
-
29344444077
-
Phenotypic taxonomy and metabolite profiling in microbial drug discovery
-
Larsen, T.O.; Smedsgaard, J.; Nielsen, K.F.; Hansen, M.E.; Frisvad, J.C. Phenotypic taxonomy and metabolite profiling in microbial drug discovery. Nat. Prod. Rep. 2005, 22, 672-695.
-
(2005)
Nat. Prod. Rep.
, vol.22
, pp. 672-695
-
-
Larsen, T.O.1
Smedsgaard, J.2
Nielsen, K.F.3
Hansen, M.E.4
Frisvad, J.C.5
-
62
-
-
34250779428
-
Chemgps-np: Tuned for navigation in biologically relevant chemical space
-
Larsson, J.; Gottfries, J.; Muresan, S.; Backlund, A. Chemgps-np: Tuned for navigation in biologically relevant chemical space. J. Nat. Prod. 2007, 70, 789-794.
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 789-794
-
-
Larsson, J.1
Gottfries, J.2
Muresan, S.3
Backlund, A.4
-
63
-
-
84904860424
-
Unexplored hypersaline habitats are sources of novel actinomycetes
-
Jose, P.A.; Jebakumar, S.R.D. Unexplored hypersaline habitats are sources of novel actinomycetes. Front. Microbiol. 2014, 5, 242.
-
(2014)
Front. Microbiol.
, vol.5
, pp. 242
-
-
Jose, P.A.1
Jebakumar, S.R.D.2
-
64
-
-
77952495893
-
Development of novel drugs from marine surface associated microorganisms
-
Penesyan, A.; Kjelleberg, S.; Egan, S. Development of novel drugs from marine surface associated microorganisms. Mar. Drugs 2010, 8, 438-459.
-
(2010)
Mar. Drugs
, vol.8
, pp. 438-459
-
-
Penesyan, A.1
Kjelleberg, S.2
Egan, S.3
-
65
-
-
66749133970
-
Antimicrobial activity observed among cultured marine epiphytic bacteria reflects their potential as a source of new drugs
-
Penesyan, A.; Marshall-Jones, Z.; Holmstrom, C.; Kjelleberg, S.; Egan, S. Antimicrobial activity observed among cultured marine epiphytic bacteria reflects their potential as a source of new drugs. FEMS Microbiol. Ecol. 2009, 69, 113-124.
-
(2009)
FEMS Microbiol. Ecol.
, vol.69
, pp. 113-124
-
-
Penesyan, A.1
Marshall-Jones, Z.2
Holmstrom, C.3
Kjelleberg, S.4
Egan, S.5
-
66
-
-
84892694830
-
Marine natural products
-
Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munro, M.H.G.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2014, 31, 160-258.
-
(2014)
Nat. Prod. Rep.
, vol.31
, pp. 160-258
-
-
Blunt, J.W.1
Copp, B.R.2
Keyzers, R.A.3
Munro, M.H.G.4
Prinsep, M.R.5
-
67
-
-
84872572982
-
Marine natural products
-
Blunt, J.W.; Copp, B.R.; Keyzers, R.A.; Munro, M.H.G.; Prinsep, M.R. Marine natural products. Nat. Prod. Rep. 2013, 30, 237-323.
-
(2013)
Nat. Prod. Rep.
, vol.30
, pp. 237-323
-
-
Blunt, J.W.1
Copp, B.R.2
Keyzers, R.A.3
Munro, M.H.G.4
Prinsep, M.R.5
-
68
-
-
14544294545
-
Bioactive microbial metabolites: A personal view
-
Bérdy, J. Bioactive microbial metabolites: A personal view. J. Antibiot. (Tokyo) 2005, 58, 1-26.
-
(2005)
J. Antibiot. (Tokyo)
, vol.58
, pp. 1-26
-
-
Bérdy, J.1
-
69
-
-
10344227692
-
Metagenomics: Application of genomics to uncultured microorganisms
-
Handelsman, J. Metagenomics: Application of genomics to uncultured microorganisms. Microbiol. Mol. Biol. Rev. 2004, 68, 669-685.
-
(2004)
Microbiol. Mol. Biol. Rev.
, vol.68
, pp. 669-685
-
-
Handelsman, J.1
-
70
-
-
84873118613
-
Assessing the effectiveness of functional genetic screens for the identification of bioactive metabolites
-
Penesyan, A.; Ballestriero, F.; Daim, M.; Kjelleberg, S.; Thomas, T.; Egan, S. Assessing the effectiveness of functional genetic screens for the identification of bioactive metabolites. Mar. Drugs 2013, 11, 40-49.
-
(2013)
Mar. Drugs
, vol.11
, pp. 40-49
-
-
Penesyan, A.1
Ballestriero, F.2
Daim, M.3
Kjelleberg, S.4
Thomas, T.5
Egan, S.6
-
71
-
-
84922937832
-
A new antibiotic kills pathogens without detectable resistance
-
Ling, L.L.; Schneider, T.; Peoples, A.J.; Spoering, A.L.; Engels, I.; Conlon, B.P.; Mueller, A.; Schaberle, T.F.; Hughes, D.E.; Epstein, S.; et al. A new antibiotic kills pathogens without detectable resistance. Nature 2015, 517, 455-459.
-
(2015)
Nature
, vol.517
, pp. 455-459
-
-
Ling, L.L.1
Schneider, T.2
Peoples, A.J.3
Spoering, A.L.4
Engels, I.5
Conlon, B.P.6
Mueller, A.7
Schaberle, T.F.8
Hughes, D.E.9
Epstein, S.10
-
72
-
-
84859643086
-
Combinatorial biosynthesis of polyketides - A perspective
-
Wong, F.T.; Khosla, C. Combinatorial biosynthesis of polyketides-a perspective. Curr. Opin. Chem. Biol. 2012, 16, 117-123.
-
(2012)
Curr. Opin. Chem. Biol.
, vol.16
, pp. 117-123
-
-
Wong, F.T.1
Khosla, C.2
-
73
-
-
33744537000
-
Combinatorial biosynthesis-potential and problems
-
Floss, H.G. Combinatorial biosynthesis-potential and problems. J. Biotechnol. 2006, 124, 242-257.
-
(2006)
J. Biotechnol.
, vol.124
, pp. 242-257
-
-
Floss, H.G.1
-
74
-
-
0029310653
-
Combinatorial biosynthesis of "unnatural" natural products: The polyketide example
-
Tsoi, C.J.; Khosla, C. Combinatorial biosynthesis of "unnatural" natural products: The polyketide example. Chem. Biol. 1995, 2, 355-362.
-
(1995)
Chem. Biol.
, vol.2
, pp. 355-362
-
-
Tsoi, C.J.1
Khosla, C.2
-
75
-
-
77956261727
-
Programming of erythromycin biosynthesis by a modular polyketide synthase
-
Cane, D.E. Programming of erythromycin biosynthesis by a modular polyketide synthase. J. Biol. Chem. 2010, 285, 27517-27523.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 27517-27523
-
-
Cane, D.E.1
-
76
-
-
80054760185
-
Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite
-
Fisch, K.M.; Bakeer, W.; Yakasai, A.A.; Song, Z.; Pedrick, J.; Wasil, Z.; Bailey, A.M.; Lazarus, C.M.; Simpson, T.J.; Cox, R.J. Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite. J. Am. Chem. Soc. 2011, 133, 16635-16641.
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 16635-16641
-
-
Fisch, K.M.1
Bakeer, W.2
Yakasai, A.A.3
Song, Z.4
Pedrick, J.5
Wasil, Z.6
Bailey, A.M.7
Lazarus, C.M.8
Simpson, T.J.9
Cox, R.J.10
-
78
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn, F.E.; Carter, G.T. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov. 2005, 4, 206-220.
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
79
-
-
39449103059
-
The epidemic of antibiotic-resistant infections: A call to action for the medical community from the infectious diseases society of america
-
Spellberg, B.; Guidos, R.; Gilbert, D.; Bradley, J.; Boucher, H.W.; Scheld, W.M.; Bartlett, J.G.; Edwards, J.; America, T.I.D.S.O. The epidemic of antibiotic-resistant infections: A call to action for the medical community from the infectious diseases society of america. Clin. Infect. Dis. 2008, 46, 155-164.
-
(2008)
Clin. Infect. Dis.
, vol.46
, pp. 155-164
-
-
Spellberg, B.1
Guidos, R.2
Gilbert, D.3
Bradley, J.4
Boucher, H.W.5
Scheld, W.M.6
Bartlett, J.G.7
Edwards, J.8
America, T.I.D.S.O.9
-
80
-
-
83855165110
-
Should we stay or should we go: Mechanisms and ecological consequences for biofilm dispersal
-
McDougald, D.; Rice, S.A.; Barraud, N.; Steinberg, P.D.; Kjelleberg, S. Should we stay or should we go: Mechanisms and ecological consequences for biofilm dispersal. Nat. Rev. Microbiol. 2012, 10, 39-50.
-
(2012)
Nat. Rev. Microbiol.
, vol.10
, pp. 39-50
-
-
McDougald, D.1
Rice, S.A.2
Barraud, N.3
Steinberg, P.D.4
Kjelleberg, S.5
-
81
-
-
77951865142
-
D-amino acids trigger biofilm disassembly
-
Kolodkin-Gal, I.; Romero, D.; Cao, S.; Clardy, J.; Kolter, R.; Losick, R. D-amino acids trigger biofilm disassembly. Science 2010, 328, 627-629.
-
(2010)
Science
, vol.328
, pp. 627-629
-
-
Kolodkin-Gal, I.1
Romero, D.2
Cao, S.3
Clardy, J.4
Kolter, R.5
Losick, R.6
-
82
-
-
80053610673
-
Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development
-
Hochbaum, A.I.; Kolodkin-Gal, I.; Foulston, L.; Kolter, R.; Aizenberg, J.; Losick, R. Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development. J. Bacteriol. 2011, 193, 5616-5622.
-
(2011)
J. Bacteriol.
, vol.193
, pp. 5616-5622
-
-
Hochbaum, A.I.1
Kolodkin-Gal, I.2
Foulston, L.3
Kolter, R.4
Aizenberg, J.5
Losick, R.6
-
83
-
-
33750479893
-
Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa
-
Barraud, N.; Hassett, D.J.; Hwang, S.H.; Rice, S.A.; Kjelleberg, S.; Webb, J.S. Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa. J. Bacteriol. 2006, 188, 7344-7353.
-
(2006)
J. Bacteriol.
, vol.188
, pp. 7344-7353
-
-
Barraud, N.1
Hassett, D.J.2
Hwang, S.H.3
Rice, S.A.4
Kjelleberg, S.5
Webb, J.S.6
-
84
-
-
72249092095
-
Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, and enhanced dispersal
-
Barraud, N.; Schleheck, D.; Klebensberger, J.; Webb, J.S.; Hassett, D.J.; Rice, S.A.; Kjelleberg, S. Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, and enhanced dispersal. J. Bacteriol. 2009, 191, 7333-7342.
-
(2009)
J. Bacteriol.
, vol.191
, pp. 7333-7342
-
-
Barraud, N.1
Schleheck, D.2
Klebensberger, J.3
Webb, J.S.4
Hassett, D.J.5
Rice, S.A.6
Kjelleberg, S.7
-
85
-
-
51949104801
-
Human host defense peptide ll-37 prevents bacterial biofilm formation
-
Overhage, J.; Campisano, A.; Bains, M.; Torfs, E.C.W.; Rehm, B.H.A.; Hancock, R.E.W. Human host defense peptide ll-37 prevents bacterial biofilm formation. Infect. Immun. 2008, 76, 4176-4182.
-
(2008)
Infect. Immun.
, vol.76
, pp. 4176-4182
-
-
Overhage, J.1
Campisano, A.2
Bains, M.3
Torfs, E.C.W.4
Rehm, B.H.A.5
Hancock, R.E.W.6
-
86
-
-
84860186340
-
Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide
-
De La Fuente-Núñez, C.; Korolik, V.; Bains, M.; Nguyen, U.; Breidenstein, E.B.M.; Horsman, S.; Lewenza, S.; Burrows, L.; Hancock, R.E.W. Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide. Antimicrob. Agents Chemother. 2012, 56, 2696-2704.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 2696-2704
-
-
De La Fuente-Núñez, C.1
Korolik, V.2
Bains, M.3
Nguyen, U.4
Breidenstein, E.B.M.5
Horsman, S.6
Lewenza, S.7
Burrows, L.8
Hancock, R.E.W.9
-
87
-
-
0033060727
-
Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein
-
Manefield, M.; de Nys, R.; Kumar, N.; Read, R.; Givskov, M.; Steinberg, P.; Kjelleberg, S. Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. Microbiology 1999, 145, 283-291.
-
(1999)
Microbiology
, vol.145
, pp. 283-291
-
-
Manefield, M.1
De Nys, R.2
Kumar, N.3
Read, R.4
Givskov, M.5
Steinberg, P.6
Kjelleberg, S.7
-
88
-
-
68549130154
-
Controlling bacterial infection by inhibiting intercellular signalling
-
Manefield, M.; Kjelleberg, S.; Givskov, M. Controlling bacterial infection by inhibiting intercellular signalling. Curr. Med. Chem.: Anti-Infect. Agents 2003, 2, 213-218.
-
(2003)
Curr. Med. Chem.: Anti-Infect. Agents
, vol.2
, pp. 213-218
-
-
Manefield, M.1
Kjelleberg, S.2
Givskov, M.3
-
89
-
-
41049083941
-
Quorum sensing inhibitory drugs as next generation antimicrobials: Worth the effort?
-
Bjarnsholt, T.; Givskov, M. Quorum sensing inhibitory drugs as next generation antimicrobials: Worth the effort? Curr. Infect. Dis. Rep. 2008, 10, 22-28.
-
(2008)
Curr. Infect. Dis. Rep.
, vol.10
, pp. 22-28
-
-
Bjarnsholt, T.1
Givskov, M.2
|