-
1
-
-
2942635256
-
Paul Ehrlich - In search of the magic bullet
-
Winau, F., Westphal, O. & Winau, R. Paul Ehrlich - in search of the magic bullet. Microbes Infect. 6, 786-789 (2004).
-
(2004)
Microbes Infect.
, vol.6
, pp. 786-789
-
-
Winau, F.1
Westphal, O.2
Winau, R.3
-
3
-
-
0242291985
-
Why is big Pharma getting out of antibacterial drug discovery?
-
Projan, S. J. Why is big Pharma getting out of antibacterial drug discovery? Curr. Opin. Microbiol. 6, 427-430 (2003).
-
(2003)
Curr. Opin. Microbiol.
, vol.6
, pp. 427-430
-
-
Projan, S.J.1
-
4
-
-
15544384259
-
Antibacterial drug discovery: Is it all downhill from here?
-
Projan, S. J. & Shlaes, D. M. Antibacterial drug discovery: Is it all downhill from here? Clin. Microbiol. Infect. 10 (Suppl. 4), 18-22 (2004).
-
(2004)
Clin. Microbiol. Infect.
, vol.10
, Issue.SUPPL. 4
, pp. 18-22
-
-
Projan, S.J.1
Shlaes, D.M.2
-
5
-
-
33745270570
-
Mechanisms of antimicrobial resistance in bacteria
-
discussion S62-S70
-
Tenover, F. C. Mechanisms of antimicrobial resistance in bacteria. Am. J. Med. 119, S3-S10; discussion S62-S70 (2006).
-
(2006)
Am. J. Med.
, vol.119
-
-
Tenover, F.C.1
-
6
-
-
33646835423
-
Resistance in nonfermenting Gram-negative bacteria: Multidrug resistance to the maximum
-
discussion S64-S73
-
McGowan, J. E. Jr. Resistance in nonfermenting Gram-negative bacteria: multidrug resistance to the maximum. Am. J. Infect. Control 34, S29-S37; discussion S64-S73 (2006).
-
(2006)
Am. J. Infect. Control
, vol.34
-
-
McGowan Jr., J.E.1
-
7
-
-
33645804394
-
Clarithromycin is an effective immunomodulator in experimental pyelonephritis caused by pan-resistant Klebsiella pneumoniae
-
Giamarellos-Bourboulis, E. J. et al. Clarithromycin is an effective immunomodulator in experimental pyelonephritis caused by pan-resistant Klebsiella pneumoniae. J. Antimicrob. Chemother. 57, 937-944 (2006).
-
(2006)
J. Antimicrob. Chemother.
, vol.57
, pp. 937-944
-
-
Giamarellos-Bourboulis, E.J.1
-
8
-
-
10944272743
-
Antibacterial resistance worldwide: Causes, challenges and responses
-
Levy, S. B. & Marshall, B. Antibacterial resistance worldwide: Causes, challenges and responses. Nature Med. 10, S122-S129 (2004).
-
(2004)
Nature Med.
, vol.10
-
-
Levy, S.B.1
Marshall, B.2
-
9
-
-
16644364407
-
The need for new antibiotics
-
Livermore, D. M. The need for new antibiotics. Clin. Microbiol. Infect. 10 (Suppl. 4), 1-9 (2004).
-
(2004)
Clin. Microbiol. Infect.
, vol.10
, Issue.SUPPL. 4
, pp. 1-9
-
-
Livermore, D.M.1
-
11
-
-
33644517894
-
Unmet medical needs in antibacterial therapy
-
Rice, L. B. Unmet medical needs in antibacterial therapy. Biochem. Pharmacol. 71, 991-995 (2006).
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 991-995
-
-
Rice, L.B.1
-
12
-
-
20144388398
-
Re-emergence of early pandemic Staphylococcus aureus as a community-acquired methicillin-resistant clone
-
Robinson, D. A. et al. Re-emergence of early pandemic Staphylococcus aureus as a community-acquired methicillin-resistant clone. Lancet 365, 1256-1258 (2005).
-
(2005)
Lancet
, vol.365
, pp. 1256-1258
-
-
Robinson, D.A.1
-
13
-
-
33645817952
-
Clinical implications and treatment of multiresistant Streptococcus pneumoniae pneumonia
-
File, T. M. Jr. Clinical implications and treatment of multiresistant Streptococcus pneumoniae pneumonia. Clin. Microbiol. Infect. 12 (Suppl. 3), 31-41 (2006).
-
(2006)
Clin. Microbiol. Infect.
, vol.12
, Issue.SUPPL. 3
, pp. 31-41
-
-
File Jr., T.M.1
-
14
-
-
33745505203
-
Foundations of antibiotic resistance in bacterial physiology: The mycobacterial paradigm
-
Nguyen, L. & Thompson, C. J. Foundations of antibiotic resistance in bacterial physiology: The mycobacterial paradigm. Trends Microbiol. 14, 304-312 (2006).
-
(2006)
Trends Microbiol.
, vol.14
, pp. 304-312
-
-
Nguyen, L.1
Thompson, C.J.2
-
15
-
-
31544443526
-
Escherichia coli K- 12: A cooperatively developed annotation snapshot - 2005
-
Riley, M. et al. Escherichia coli K- 12: A cooperatively developed annotation snapshot - 2005. Nucleic Acids Res. 34, 1-9 (2006).
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 1-9
-
-
Riley, M.1
-
16
-
-
0038670226
-
Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
-
Yu, E. W., McDermott, G., Zgurskaya, H. I., Nikaido, H. & Koshland, D. E. Jr. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 300, 976-980 (2003).
-
(2003)
Science
, vol.300
, pp. 976-980
-
-
Yu, E.W.1
McDermott, G.2
Zgurskaya, H.I.3
Nikaido, H.4
Koshland Jr., D.E.5
-
17
-
-
0028030082
-
Mechanisms underlying expression of Tn 10 encoded tetracycline resistance
-
Hillen, W. & Berens, C. Mechanisms underlying expression of Tn 10 encoded tetracycline resistance. Annu. Rev. Microbiol. 48, 345-369 (1994).
-
(1994)
Annu. Rev. Microbiol.
, vol.48
, pp. 345-369
-
-
Hillen, W.1
Berens, C.2
-
18
-
-
20544432535
-
The TetR family of transcriptional repressors
-
Ramos, J. L. et al. The TetR family of transcriptional repressors. Microbiol. Mol. Biol. Rev. 69, 326-356 (2005).
-
(2005)
Microbiol. Mol. Biol. Rev.
, vol.69
, pp. 326-356
-
-
Ramos, J.L.1
-
19
-
-
0032844440
-
The mar regulon: Multiple resistance to antibiotics and other toxic chemicals
-
Alekshun, M. N. & Levy, S. B. The mar regulon: Multiple resistance to antibiotics and other toxic chemicals. Trends Microbiol. 7, 410-413 (1999).
-
(1999)
Trends Microbiol.
, vol.7
, pp. 410-413
-
-
Alekshun, M.N.1
Levy, S.B.2
-
20
-
-
4644248905
-
Dual effects of MLS antibiotics: Transcriptional modulation and interactions on the ribosome
-
Tsui, W. H. et al. Dual effects of MLS antibiotics: Transcriptional modulation and interactions on the ribosome. Chem. Biol. 11, 1307-1316 (2004).
-
(2004)
Chem. Biol.
, vol.11
, pp. 1307-1316
-
-
Tsui, W.H.1
-
21
-
-
0037168560
-
Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics
-
Goh, E. B. et al. Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proc. Natl Acad. Sci. USA 99, 17025-17030 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 17025-17030
-
-
Goh, E.B.1
-
22
-
-
22144476125
-
Bacterial resistance to antibiotics: Enzymatic degradation and modification
-
Wright, G. D. Bacterial resistance to antibiotics: Enzymatic degradation and modification. Adv. Drug Deliv. Rev. 57, 1451-1470 (2005).
-
(2005)
Adv. Drug Deliv. Rev.
, vol.57
, pp. 1451-1470
-
-
Wright, G.D.1
-
23
-
-
0036174606
-
Glycopeptide antibiotic resistance
-
Pootoolal, J., Neu, J. & Wright, G. D. Glycopeptide antibiotic resistance. Annu. Rev. Pharmacol. Toxicol. 42, 381-408 (2002).
-
(2002)
Annu. Rev. Pharmacol. Toxicol.
, vol.42
, pp. 381-408
-
-
Pootoolal, J.1
Neu, J.2
Wright, G.D.3
-
24
-
-
0029678259
-
Bacterial resistance to vancomycin: Five genes and one missing hydrogen bond tell the story
-
Walsh, C. T., Fisher, S. L., Park, I.-S., Prohalad, M. & Wu, Z. Bacterial resistance to vancomycin: Five genes and one missing hydrogen bond tell the story. Chem. Biol. 3, 21-28 (1996).
-
(1996)
Chem. Biol.
, vol.3
, pp. 21-28
-
-
Walsh, C.T.1
Fisher, S.L.2
Park, I.-S.3
Prohalad, M.4
Wu, Z.5
-
25
-
-
0037253903
-
Linezolid resistance in clinical isolates of Staphylococcus aureus
-
Wilson, P. et al. Linezolid resistance in clinical isolates of Staphylococcus aureus. J. Antimicrob. Chemother. 51, 186-188 (2003).
-
(2003)
J. Antimicrob. Chemother.
, vol.51
, pp. 186-188
-
-
Wilson, P.1
-
26
-
-
12944262276
-
Aminoglycoside resistance in Pseudomonas aeruginosa
-
Poole, K. Aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 49, 479-487 (2005).
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 479-487
-
-
Poole, K.1
-
27
-
-
31144458334
-
Sampling the antibiotic resistome
-
D'Costa, V. M., McGrann, K. M., Hughes, D. W. & Wright, G. D. Sampling the antibiotic resistome. Science 311, 374-377 (2006).
-
(2006)
Science
, vol.311
, pp. 374-377
-
-
D'Costa, V.M.1
McGrann, K.M.2
Hughes, D.W.3
Wright, G.D.4
-
28
-
-
33646251815
-
Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria
-
Piddock, L. J. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin. Microbiol. Rev. 19, 382-402 (2006).
-
(2006)
Clin. Microbiol. Rev.
, vol.19
, pp. 382-402
-
-
Piddock, L.J.1
-
29
-
-
0035353081
-
Multidrug efflux in Pseudomonas aeruginosa: Components, mechanisms and clinical significance
-
Poole, K. & Srikumar, R. Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance. Curr. Top Med. Chem. 1, 59-71 (2001).
-
(2001)
Curr. Top Med. Chem.
, vol.1
, pp. 59-71
-
-
Poole, K.1
Srikumar, R.2
-
30
-
-
0034739007
-
Complete genome sequence of Pseudomonas aeruginosa PAO 1, an opportunistic pathogen
-
Stover, C. K. et al. Complete genome sequence of Pseudomonas aeruginosa PAO 1, an opportunistic pathogen. Nature 406, 959-964 (2000).
-
(2000)
Nature
, vol.406
, pp. 959-964
-
-
Stover, C.K.1
-
31
-
-
33747154459
-
Multidrug-resistance efflux pumps - Not just for resistance
-
Piddock, L. J. Multidrug-resistance efflux pumps - not just for resistance. Nature Rev. Microbiol. 4, 629-636 (2006).
-
(2006)
Nature Rev. Microbiol.
, vol.4
, pp. 629-636
-
-
Piddock, L.J.1
-
32
-
-
14844362964
-
Bacterial resistance to β-lactam antibiotics: Compelling opportunism, compelling opportunity
-
Fisher, J. F., Meroueh, S. O. & Mobashery, S. Bacterial resistance to β-lactam antibiotics: Compelling opportunism, compelling opportunity. Chem. Rev. 105, 395-424 (2005).
-
(2005)
Chem. Rev.
, vol.105
, pp. 395-424
-
-
Fisher, J.F.1
Meroueh, S.O.2
Mobashery, S.3
-
33
-
-
0037133299
-
Crystal structure of Vat(D): An acetyltransferase that inactivates streptogramin group A antibiotics
-
Sugantino, M. & Roderick, S. L. Crystal structure of Vat(D): An acetyltransferase that inactivates streptogramin group A antibiotics. Biochemistry 41, 2209-2216 (2002).
-
(2002)
Biochemistry
, vol.41
, pp. 2209-2216
-
-
Sugantino, M.1
Roderick, S.L.2
-
34
-
-
0034023160
-
Identification of a streptogramin A acetyltransferase gene in the chromosome of Yersinia enterocolitica
-
Seoane, A. & Garcia Lobo, J. M. Identification of a streptogramin A acetyltransferase gene in the chromosome of Yersinia enterocolitica. Antimicrob. Agents Chemother. 44, 905-909 (2000).
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 905-909
-
-
Seoane, A.1
Garcia Lobo, J.M.2
-
35
-
-
0035979331
-
Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis
-
Mukhtar, T. A., Koteva, K. P., Hughes, D. W. & Wright, G. D. Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis. Biochemistry 40, 8877-8886 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 8877-8886
-
-
Mukhtar, T.A.1
Koteva, K.P.2
Hughes, D.W.3
Wright, G.D.4
-
37
-
-
0036721015
-
β-Lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types
-
Humeniuk, C. et al. β-Lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types. Antimicrob. Agents Chemother. 46, 3045-3049 (2002).
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 3045-3049
-
-
Humeniuk, C.1
-
38
-
-
0036894253
-
Chromosome-encoded Ambler class A β-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum β-lactamases
-
Poirel, L., Kampfer, P. & Nordmann, P. Chromosome-encoded Ambler class A β-lactamase of Kluyvera georgiana, a probable progenitor of a subgroup of CTX-M extended-spectrum β-lactamases. Antimicrob. Agents Chemother. 46, 4038-4040 (2002).
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 4038-4040
-
-
Poirel, L.1
Kampfer, P.2
Nordmann, P.3
-
39
-
-
0035189969
-
Characterization of a chromosomally encoded extended-spectrum class A β-lactamase from Kluyvera cryocrescens
-
Decousser, J. W., Poirel, L & Nordmann, P. Characterization of a chromosomally encoded extended-spectrum class A β-lactamase from Kluyvera cryocrescens. Antimicrob. Agents Chemother. 45, 3595-3598 (2001).
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 3595-3598
-
-
Decousser, J.W.1
Poirel, L.2
Nordmann, P.3
-
40
-
-
33645756099
-
In vitro analysis of ISEcp 1B-mediated mobilization of naturally occurring β-lactamase gene blaCTX-M of Kluyvera ascorbata
-
Lartigue, M. F., Poirel, L., Aubert, D. & Nordmann, P. In vitro analysis of ISEcp 1B-mediated mobilization of naturally occurring β-lactamase gene blaCTX-M of Kluyvera ascorbata. Antimicrob. Agents Chemother. 50, 1282-1286 (2006).
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 1282-1286
-
-
Lartigue, M.F.1
Poirel, L.2
Aubert, D.3
Nordmann, P.4
-
41
-
-
0032226544
-
Aminoglycoside antibiotics. Structures, functions, and resistance
-
Wright, G. D., Berghuis, A. M. & Mobashery, S. Aminoglycoside antibiotics. Structures, functions, and resistance. Adv. Exp. Med. Biol. 456, 27-69 (1998).
-
(1998)
Adv. Exp. Med. Biol.
, vol.456
, pp. 27-69
-
-
Wright, G.D.1
Berghuis, A.M.2
Mobashery, S.3
-
42
-
-
0030008129
-
Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene aph(3′)-llb in Pseudomonas aeruginosa
-
Hachler, H., Santarnam, P. & Kayser, F. H. Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene aph(3′)-llb in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 40, 1254-1256 (1996).
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 1254-1256
-
-
Hachler, H.1
Santarnam, P.2
Kayser, F.H.3
-
43
-
-
0032510981
-
Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues
-
Thompson, P. R., Hughes, D. W., Cianciotto, N. P. & Wright, G. D. Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues. J. Biol. Chem. 273, 14788-14795 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14788-14795
-
-
Thompson, P.R.1
Hughes, D.W.2
Cianciotto, N.P.3
Wright, G.D.4
-
44
-
-
0037300533
-
Functional annotation of putative aminoglycoside antibiotic modifying proteins in Mycobacterium tuberculosis H37Rv
-
Draker, K. A., Boehr, D. D., Elowe, N. H., Noga, T. J. & Wright, G. D. Functional annotation of putative aminoglycoside antibiotic modifying proteins in Mycobacterium tuberculosis H37Rv. J. Antibiot. (Tokyo) 56, 135-142 (2003).
-
(2003)
J. Antibiot. (Tokyo)
, vol.56
, pp. 135-142
-
-
Draker, K.A.1
Boehr, D.D.2
Elowe, N.H.3
Noga, T.J.4
Wright, G.D.5
-
45
-
-
0042423715
-
Insertion sequence ISEcp 1B is involved in expression and mobilization of a bla(CTX-M) β-lactamase gene
-
Poirel, L., Decousser, J. W. & Nordmann, P. Insertion sequence ISEcp 1B is involved in expression and mobilization of a bla(CTX-M) β-lactamase gene. Antimicrob. Agents Chemother. 47, 2938-2945 (2003).
-
(2003)
Antimicrob. Agents Chemother.
, vol.47
, pp. 2938-2945
-
-
Poirel, L.1
Decousser, J.W.2
Nordmann, P.3
-
46
-
-
33745125702
-
ISCR elements: Novel gene-capturing systems of the 21st century?
-
Toleman, M. A., Bennett, P. M. & Walsh, T. R. ISCR elements: Novel gene-capturing systems of the 21st century? Microbiol. Mol. Biol. Rev. 70, 296-316 (2006).
-
(2006)
Microbiol. Mol. Biol. Rev.
, vol.70
, pp. 296-316
-
-
Toleman, M.A.1
Bennett, P.M.2
Walsh, T.R.3
-
47
-
-
0000467078
-
Antibiotic resistance in Gram-negative bacteria: The role of gene cassettes and integrons
-
Hall, R. M. & Collis, C. M. Antibiotic resistance in Gram-negative bacteria: The role of gene cassettes and integrons. Drug Resist. Updat. 1, 109-119 (1998).
-
(1998)
Drug Resist. Updat.
, vol.1
, pp. 109-119
-
-
Hall, R.M.1
Collis, C.M.2
-
48
-
-
0035859832
-
2-fixing endosymbiont Sinorhizobium meliloti
-
2-fixing endosymbiont Sinorhizobium meliloti. Proc. Natl Acad. Sci. USA 98, 9889-9894 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 9889-9894
-
-
Finan, T.M.1
-
49
-
-
7244248958
-
The complete nucleotide sequence of the resistance plasmid R478: Defining the backbone components of incompatibility group H conjugative plasmids through comparative genomics
-
Gilmour, M. W., Thomson, N. R., Sanders, M., Parkhill, J. & Taylor, D. E. The complete nucleotide sequence of the resistance plasmid R478: defining the backbone components of incompatibility group H conjugative plasmids through comparative genomics. Plasmid 52, 182-202 (2004).
-
(2004)
Plasmid
, vol.52
, pp. 182-202
-
-
Gilmour, M.W.1
Thomson, N.R.2
Sanders, M.3
Parkhill, J.4
Taylor, D.E.5
-
50
-
-
33748807214
-
Sequence analysis of the lactococcal plasmid pNP40: A mobile replicon for coping with environmental hazards
-
O'Driscoll, J., Glynn, F., Fitzgerald, G. F. & van Sinderen, D. Sequence analysis of the lactococcal plasmid pNP40: A mobile replicon for coping with environmental hazards. J. Bacteriol. 188, 6629-6639 (2006).
-
(2006)
J. Bacteriol.
, vol.188
, pp. 6629-6639
-
-
O'Driscoll, J.1
Glynn, F.2
Fitzgerald, G.F.3
van Sinderen, D.4
-
51
-
-
33744536067
-
Antibiotic discovery from actinomycetes: Will a renaissance follow the decline and fall?
-
Baltz, R. H. Antibiotic discovery from actinomycetes: Will a renaissance follow the decline and fall? SIM News 55, 186-196 (2005).
-
(2005)
SIM News
, vol.55
, pp. 186-196
-
-
Baltz, R.H.1
-
52
-
-
2942562249
-
Evolution of the serine β-lactamases: Past, present and future
-
Hall, B. G. & Barlow, M. Evolution of the serine β-lactamases: Past, present and future. Drug Resist. Updat. 7. 111-123 (2004).
-
(2004)
Drug Resist. Updat.
, vol.7
, pp. 111-123
-
-
Hall, B.G.1
Barlow, M.2
-
53
-
-
0024459873
-
How antibiotic-producing organisms avoid suicide
-
Cundliffe, E. How antibiotic-producing organisms avoid suicide. Annu. Rev. Microbiol. 43, 207-233 (1989).
-
(1989)
Annu. Rev. Microbiol.
, vol.43
, pp. 207-233
-
-
Cundliffe, E.1
-
54
-
-
0021154432
-
The structure and mode of action of glycopeptide antibiotics of the vancomycin group
-
Barna, J. C. & Williams, D. H. The structure and mode of action of glycopeptide antibiotics of the vancomycin group. Annu. Rev. Microbiol. 38, 339-357 (1984).
-
(1984)
Annu. Rev. Microbiol.
, vol.38
, pp. 339-357
-
-
Barna, J.C.1
Williams, D.H.2
-
55
-
-
0031979496
-
Historical yearly usage of vancomycin
-
Kirst, H. A., Thompson, D. G. & Nicas, T. I. Historical yearly usage of vancomycin. Antimicrob. Agents Chemother. 42, 1303-1304 (1998).
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 1303-1304
-
-
Kirst, H.A.1
Thompson, D.G.2
Nicas, T.I.3
-
56
-
-
0023808730
-
Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium
-
Leclercq, R., Derlot, E., Duval, J. & Courvalin, P. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N. Engl. J. Med. 319, 157-161 (1988).
-
(1988)
N. Engl. J. Med.
, vol.319
, pp. 157-161
-
-
Leclercq, R.1
Derlot, E.2
Duval, J.3
Courvalin, P.4
-
57
-
-
9144264415
-
Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania
-
Tenover, F. C. et al. Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania. Antimicrob. Agents Chemother. 48, 275-280 (2004).
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 275-280
-
-
Tenover, F.C.1
-
58
-
-
2342507884
-
Vancomycin-resistant Staphylococcus aureus in the absence of vancomycin exposure
-
Whitener, C. J. et al. Vancomycin-resistant Staphylococcus aureus in the absence of vancomycin exposure. Clin. Infect Dis. 38, 1049-1055 (2004).
-
(2004)
Clin. Infect. Dis.
, vol.38
, pp. 1049-1055
-
-
Whitener, C.J.1
-
59
-
-
0029965852
-
Mechanisms of glycopeptide resistance in enterococci
-
Arthur, M. et al. Mechanisms of glycopeptide resistance in enterococci. J. Infect. 32, 11-16 (1996).
-
(1996)
J. Infect.
, vol.32
, pp. 11-16
-
-
Arthur, M.1
-
60
-
-
29244441170
-
Vancomycin resistance in Gram-positive cocci
-
Courvalin, P. Vancomycin resistance in Gram-positive cocci. Clin. Infect Dis. 42 (Suppl. 1), 25-34 (2006).
-
(2006)
Clin. Infect Dis.
, vol.42
, Issue.SUPPL. 1
, pp. 25-34
-
-
Courvalin, P.1
-
61
-
-
0026355435
-
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: Biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA
-
Bugg, T. D. H. et al. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: Biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 30, 10408-10415 (1991).
-
(1991)
Biochemistry
, vol.30
, pp. 10408-10415
-
-
Bugg, T.D.H.1
-
62
-
-
0030911603
-
D-ala-D-ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB
-
Marshall, C. G., Broadhead, G., Leskiw, B. K. & Wright, G. D. D-ala-D-ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. Proc. Natl Acad. Sci. USA 94, 6480-6483 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 6480-6483
-
-
Marshall, C.G.1
Broadhead, G.2
Leskiw, B.K.3
Wright, G.D.4
-
63
-
-
0031663280
-
Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms
-
Marshall, C. G., Lessard, I. A., Park, I. & Wright, G. D. Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms. Antimicrob. Agents Chemother. 42, 2215-2220 (1998).
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 2215-2220
-
-
Marshall, C.G.1
Lessard, I.A.2
Park, I.3
Wright, G.D.4
-
64
-
-
0031573771
-
The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both d-alanyl-d-alanine and d-alanyl-d-lactate ligases
-
Marshall, C. G. & Wright, G. D. The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both d-alanyl-d-alanine and d-alanyl-d-lactate ligases. FEMS Microbiol. Lett. 157, 295-299 (1997).
-
(1997)
FEMS Microbiol. Lett.
, vol.157
, pp. 295-299
-
-
Marshall, C.G.1
Wright, G.D.2
-
65
-
-
0031772267
-
DdIN from vancomycin-producing Amycolatopsis orientalis C329.2 is a VanA homologue with d-alanyl-d-lactate ligase activity
-
Marshall, C. G. & Wright, G. D. DdIN from vancomycin-producing Amycolatopsis orientalis C329.2 is a VanA homologue with d-alanyl-d-lactate ligase activity. J. Bacteriol. 180, 5792-5795 (1998).
-
(1998)
J. Bacteriol.
, vol.180
, pp. 5792-5795
-
-
Marshall, C.G.1
Wright, G.D.2
-
66
-
-
0033614806
-
Molecular mechanism of VanHst, an α-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism
-
Marshall, C. G., Zolli, M. & Wright, G. D. Molecular mechanism of VanHst, an α-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism. Biochemistry 38, 8485-8491 (1999).
-
(1999)
Biochemistry
, vol.38
, pp. 8485-8491
-
-
Marshall, C.G.1
Zolli, M.2
Wright, G.D.3
-
67
-
-
3142743426
-
Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vank) required for drug resistance
-
Hong, H. J. et al. Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vank) required for drug resistance. Mol. Microbiol. 52, 1107-1121 (2004).
-
(2004)
Mol. Microbiol.
, vol.52
, pp. 1107-1121
-
-
Hong, H.J.1
-
68
-
-
0033994788
-
The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster
-
Patel, R., Piper, K., Cockerill, F. R., Steckelberg, J. M. & Yousten, A. A. The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster. Antimicrob. Agents Chemother. 44, 705-709 (2000).
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 705-709
-
-
Patel, R.1
Piper, K.2
Cockerill, F.R.3
Steckelberg, J.M.4
Yousten, A.A.5
-
69
-
-
0242711908
-
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria
-
Benveniste, R. & Davies, J. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc. Natl Acad. Sci. USA 70, 2276-2280 (1973).
-
(1973)
Proc. Natl Acad. Sci. USA
, vol.70
, pp. 2276-2280
-
-
Benveniste, R.1
Davies, J.2
-
71
-
-
0035968312
-
Molecular mechanism of aminoglycoside antibiotic kinase APH(3′)-IIIa: Roles of conserved active site residues
-
Boehr, D. D., Thompson, P. R. & Wright, G. D. Molecular mechanism of aminoglycoside antibiotic kinase APH(3′)-IIIa: Roles of conserved active site residues. J. Biol. Chem. 276, 23929-23936 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23929-23936
-
-
Boehr, D.D.1
Thompson, P.R.2
Wright, G.D.3
-
72
-
-
0032774575
-
Aminoglycoside phosphotransferases required for antibiotic resistance are also serine protein kinases
-
Daigle, D. M., McKay, G. A., Thompson, P. R. & Wright, G. D. Aminoglycoside phosphotransferases required for antibiotic resistance are also serine protein kinases. Chem. Biol. 6, 11-18 (1998).
-
(1998)
Chem. Biol.
, vol.6
, pp. 11-18
-
-
Daigle, D.M.1
McKay, G.A.2
Thompson, P.R.3
Wright, G.D.4
-
73
-
-
0030848695
-
Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors
-
Daigle, D. M., McKay, G. A. & Wright, G. D. Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors. J. Biol. Chem. 272, 24755-24758 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24755-24758
-
-
Daigle, D.M.1
McKay, G.A.2
Wright, G.D.3
-
74
-
-
0030830868
-
Structure of an enzyme required for aminoglycoside resistance reveals homology to eukaryotic protein kinases
-
Hon, W. C. et al. Structure of an enzyme required for aminoglycoside resistance reveals homology to eukaryotic protein kinases. Cell 89, 887-895 (1997).
-
(1997)
Cell
, vol.89
, pp. 887-895
-
-
Hon, W.C.1
-
75
-
-
30744464566
-
Ser/Thr/Tyr protein phosphorylation in bacteria - For long time neglected. Now well established
-
Deutscher, J. & Saier, M. H. Jr. Ser/Thr/Tyr protein phosphorylation in bacteria - for long time neglected. now well established. J. Mol. Microbiol. Biotechnol. 9, 125-131 (2005).
-
(2005)
J. Mol. Microbiol. Biotechnol.
, vol.9
, pp. 125-131
-
-
Deutscher, J.1
Saier Jr., M.H.2
-
76
-
-
0029743605
-
Fancy meeting you here! a fresh look at 'prokaryotic' protein phosphorylation
-
Kennelly, P. J. & Potts, M. Fancy meeting you here! a fresh look at 'prokaryotic' protein phosphorylation. J. Bacteriol. 178, 4759-4764 (1996).
-
(1996)
J. Bacteriol.
, vol.178
, pp. 4759-4764
-
-
Kennelly, P.J.1
Potts, M.2
-
77
-
-
0037046560
-
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
-
Bentley, S. D. et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature, 417, 141-147 (2002).
-
(2002)
Nature
, vol.417
, pp. 141-147
-
-
Bentley, S.D.1
-
78
-
-
0038561132
-
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces overmitilis
-
Ikeda, H. et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces overmitilis. Nature Biotechnol. 21, 526-531 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 526-531
-
-
Ikeda, H.1
-
79
-
-
0036707544
-
Aminoglycoside 2′-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates
-
Vetting, M. W., Hegde, S. S., Javid-Majd, F., Blanchard, J. S. & Roderick, S. L. Aminoglycoside 2′-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates. Nature Struct. Biol. 9, 653-658 (2002).
-
(2002)
Nature Struct. Biol.
, vol.9
, pp. 653-658
-
-
Vetting, M.W.1
Hegde, S.S.2
Javid-Majd, F.3
Blanchard, J.S.4
Roderick, S.L.5
-
80
-
-
1942490112
-
A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones
-
Vetting, M. W., Magnet, S., Nieves, E., Roderick, S. L. & Blanchard, J. S. A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones. Chem. Biol. 11, 565-573 (2004).
-
(2004)
Chem. Biol.
, vol.11
, pp. 565-573
-
-
Vetting, M.W.1
Magnet, S.2
Nieves, E.3
Roderick, S.L.4
Blanchard, J.S.5
-
81
-
-
0032555691
-
Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase
-
Wolf, E. et al. Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase. Cell 94, 439-449 (1998).
-
(1998)
Cell
, vol.94
, pp. 439-449
-
-
Wolf, E.1
-
82
-
-
0033135707
-
Crystal structure of an aminoglycoside 6′-N-acetyltransferase: Defining the GCN5-related N-acetyltransferase superfamily fold
-
Wybenga-Groot, L., Draker, K. a., Wright, G. D. & Berghuis, A. M. Crystal structure of an aminoglycoside 6′-N-acetyltransferase:dEfining the GCN5-related N-acetyltransferase superfamily fold. Structure 7, 497-507 (1999).
-
(1999)
Structure
, vol.7
, pp. 497-507
-
-
Wybenga-Groot, L.1
Draker, K.A.2
Wright, G.D.3
Berghuis, A.M.4
-
83
-
-
9744255506
-
Structure and functions of the GNAT superfamily of acetyltransferases
-
Vetting, M. W. et al. Structure and functions of the GNAT superfamily of acetyltransferases. Arch. Biochem. Biophys. 433, 212-226 (2005).
-
(2005)
Arch. Biochem. Biophys.
, vol.433
, pp. 212-226
-
-
Vetting, M.W.1
-
84
-
-
0031973490
-
Kinship and diversification of bacterial penicillin-binding proteins and β-lactamases
-
Massova, I. & Mobashery, S. Kinship and diversification of bacterial penicillin-binding proteins and β-lactamases. Antimicrob. Agents Chemother. 42, 1-17 (1998).
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 1-17
-
-
Massova, I.1
Mobashery, S.2
-
85
-
-
30044445411
-
Fluoroquinolone-modifying enzyme: A new adaptation of a common aminoglycoside acetyltransferase
-
Robicsek, A. et al. Fluoroquinolone-modifying enzyme: A new adaptation of a common aminoglycoside acetyltransferase. Nature Med. 12. 83-88 (2006).
-
(2006)
Nature Med.
, vol.12
, pp. 83-88
-
-
Robicsek, A.1
-
86
-
-
21344460325
-
Inhibition of mutation and combating the evolution of antibiotic resistance
-
Cirz, R. T. et al. Inhibition of mutation and combating the evolution of antibiotic resistance PLoS Biol. 3, e176 (2005).
-
(2005)
PLoS Biol.
, vol.3
-
-
Cirz, R.T.1
-
87
-
-
33749585217
-
Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin
-
Cirz, R. T., O'Neill B, M., Hammond, J. A., Head, S. R. & Romesberg, F. E. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. J. Bacteriol. 188, 7101-7110 (2006).
-
(2006)
J. Bacteriol.
, vol.188
, pp. 7101-7110
-
-
Cirz, R.T.1
O'Neill, B.M.2
Hammond, J.A.3
Head, S.R.4
Romesberg, F.E.5
-
88
-
-
0033082528
-
How antibiotics cause antibiotic resistance
-
Heinemann, J. A. How antibiotics cause antibiotic resistance. Drug Discov. Today 4, 72-79 (1999).
-
(1999)
Drug Discov. Today
, vol.4
, pp. 72-79
-
-
Heinemann, J.A.1
-
89
-
-
24744436623
-
Ancestral antibiotic resistance in Mycobacterium tuberculosis
-
Morris, R. P. et al. Ancestral antibiotic resistance in Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 102, 12200-12205 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 12200-12205
-
-
Morris, R.P.1
-
90
-
-
1642304143
-
Polyketide and nonribosomal peptide antibiotics: Modularity and versatility
-
Walsh, C. T. Polyketide and nonribosomal peptide antibiotics: Modularity and versatility. Science 303, 1805-1810 (2004).
-
(2004)
Science
, vol.303
, pp. 1805-1810
-
-
Walsh, C.T.1
-
91
-
-
33644871218
-
The truth about antibiotics
-
Yim, G., Wang, H. H. & Davies, J. The truth about antibiotics. Int. J. Med. Microbiol. 296, 163-170 (2006).
-
(2006)
Int. J. Med. Microbiol.
, vol.296
, pp. 163-170
-
-
Yim, G.1
Wang, H.H.2
Davies, J.3
-
92
-
-
4344587758
-
Uncultured soil bacteria are a reservoir of new antibiotic resistance genes
-
Riesenfeld, C. S., Goodman, R. M. & Handelsman, J. Uncultured soil bacteria are a reservoir of new antibiotic resistance genes. Environ. Microbiol. 6, 981-989 (2004).
-
(2004)
Environ. Microbiol.
, vol.6
, pp. 981-989
-
-
Riesenfeld, C.S.1
Goodman, R.M.2
Handelsman, J.3
-
93
-
-
33645396484
-
Functional classification of drugs by properties of their pairwise interactions
-
Yeh, P., Tschumi, A. I. & Kishony, R. Functional classification of drugs by properties of their pairwise interactions. Nature Genet. 38, 489-494 (2006).
-
(2006)
Nature Genet.
, vol.38
, pp. 489-494
-
-
Yeh, P.1
Tschumi, A.I.2
Kishony, R.3
-
94
-
-
33748693294
-
The biological cost of mutational antibiotic resistance: Any practical conclusions?
-
Andersson, D. I. The biological cost of mutational antibiotic resistance: Any practical conclusions? Curr. Opin. Microbiol. 9, 461-465 (2006).
-
(2006)
Curr. Opin. Microbiol.
, vol.9
, pp. 461-465
-
-
Andersson, D.I.1
-
95
-
-
0242323604
-
Persistence of antibiotic resistant bacteria
-
Andersson, D. I. Persistence of antibiotic resistant bacteria. Curr. Opin. Microbiol. 6, 452-456 (2003).
-
(2003)
Curr. Opin. Microbiol.
, vol.6
, pp. 452-456
-
-
Andersson, D.I.1
-
96
-
-
33750447962
-
The role of compensatory mutations in the emergence of drug resistance
-
Handel, A., Regoes, R. R. & Antia, R. The role of compensatory mutations in the emergence of drug resistance. PLoS Comput. Biol. 2, e137 (2006).
-
(2006)
PLoS Comput. Biol.
, vol.2
-
-
Handel, A.1
Regoes, R.R.2
Antia, R.3
-
97
-
-
33646365631
-
Hydrolysis of ATP by aminoglycoside 3′-phosphotransferases: An unexpected cost to bacteria for harboring an antibiotic resistance enzyme
-
Kim, C., Cha, J. Y., Yan, H., Vakulenko, S. B. & Mobashery S. Hydrolysis of ATP by aminoglycoside 3′-phosphotransferases: An unexpected cost to bacteria for harboring an antibiotic resistance enzyme. J. Biol. Chem. 281, 6964-6969 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6964-6969
-
-
Kim, C.1
Cha, J.Y.2
Yan, H.3
Vakulenko, S.B.4
Mobashery, S.5
-
98
-
-
0027968068
-
CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
-
Thompson, J. D., Higgins, D. G. & Gibson, T. J. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680 (1994).
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 4673-4680
-
-
Thompson, J.D.1
Higgins, D.G.2
Gibson, T.J.3
-
99
-
-
0029853148
-
WWW-Query: An on-line retrieval system for biological sequence banks
-
Perrière, G. & Gouy, M. WWW-Query: An on-line retrieval system for biological sequence banks. Biochimie 78, 364-369 (1996).
-
(1996)
Biochimie
, vol.78
, pp. 364-369
-
-
Perrière, G.1
Gouy, M.2
|