Apigenin attenuates atherogenesis through inducing macrophage apoptosis via inhibition of AKT Ser473 phosphorylation and downregulation of plasminogen activator inhibitor-2

Oxidative Medicine and Cellular Longevity

Volumn 2015, Issue , 2015, Pages

  Zeng, Ping ^a   Liu, Bin ^b   Wang, Qun ^c   Fan, Qin ^c   Diao, Jian Xin ^c   Tang, Jing ^c   Fu, Xiu Qiong ^c,d   Sun, Xue Gang ^c  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; DRUG PRODUCTS; MACROPHAGES; PHOSPHORYLATION;

ANTI-APOPTOTIC EFFECTS; ANTI-ATHEROGENIC EFFECTS; ANTI-TUMOR ACTIVITIES; ATHEROSCLEROTIC LESIONS; MURINE PERITONEAL MACROPHAGES; OXIDIZED LOW-DENSITY LIPOPROTEINS (OXLDL); PLASMINOGEN ACTIVATOR INHIBITOR; POTENTIAL BINDING SITES;

FLAVONOIDS;

APIGENIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 2; PROTEIN KINASE B; SERINE; SIMVASTATIN; LOW DENSITY LIPOPROTEIN; PHOSPHOSERINE; PROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BINDING SITE; CELL VIABILITY; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; MOLECULAR BIOLOGY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEOMICS; ANIMAL; C57BL MOUSE; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECTS; HEK293 CELL LINE; HUMAN; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

MURINAE; MUS;

ANIMALS; APIGENIN; APOPTOSIS; ATHEROSCLEROSIS; CELL SURVIVAL; DOWN-REGULATION; HEK293 CELLS; HUMANS; LIPOPROTEINS, LDL; MACROPHAGES, PERITONEAL; MICE, INBRED C57BL; MOLECULAR DOCKING SIMULATION; PHOSPHORYLATION; PHOSPHOSERINE; PLASMINOGEN ACTIVATOR INHIBITOR 2; PROTECTIVE AGENTS; PROTEOMICS; PROTO-ONCOGENE PROTEINS C-AKT; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84928804775     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2015/379538     Document Type: Article

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