Cardiac effects of seasonal ambient particulate matter and ozone co-exposure in rats

Particle and Fibre Toxicology

Volumn 12, Issue 1, 2015, Pages

  Farraj, Aimen K ^a   Walsh, Leon ^a   Haykal Coates, Najwa ^a   Malik, Fatiha ^a   McGee, John ^a   Winsett, Darrell ^a   Duvall, Rachelle ^a   Kovalcik, Kasey ^a   Cascio, Wayne E ^a   Higuchi, Mark ^a   Hazari, Mehdi S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Ambient particulate matter; Cardiac; Co exposure; Electrocardiogram; Elements; Health effects; Ozone; Rats; Season; Source apportionment

Indexed keywords

ALUMINUM; ANTIMONY; ARSENIC; BARIUM; CADMIUM; CALCIUM; CARBON; CHROMIUM; COBALT; COPPER; GLUTATHIONE TRANSFERASE; IRON; LEAD; LITHIUM; MAGNESIUM; MANGANESE; MOLYBDENUM; NICKEL; ORGANIC CARBON; OZONE; PHOSPHORUS; POTASSIUM; SILICON DIOXIDE; SODIUM; SULFATE; TIN; TITANIUM; UNINDEXED DRUG; VANADIUM; ZINC; AIR POLLUTANT; PARTICULATE MATTER;

AMBIENT AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC NERVOUS SYSTEM; COHORT ANALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL TEMPERATURE; GRAVIMETRY; HEART ARRHYTHMIA; HEART RATE; HEART RATE VARIABILITY; HEART VENTRICLE TACHYCARDIA; HYPERTENSION; LUNG LAVAGE; MASS SPECTROMETRY; METEOROLOGY; NONHUMAN; PARTICLE SIZE; PARTICULATE MATTER; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SEASONAL VARIATION; SUMMER; VAPORIZATION; WINTER; ADVERSE EFFECTS; AIR POLLUTANT; ANALYSIS; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICALLY INDUCED; CHEMISTRY; DEVICES; DRUG EFFECTS; ENZYMOLOGY; EQUIPMENT DESIGN; EXPOSURE; IMMUNOLOGY; LUNG; MALE; PROCEDURES; SEASON; TOXICITY; TOXICITY TESTING; WEATHER;

RATTUS;

AIR POLLUTANTS; ANIMALS; ARRHYTHMIAS, CARDIAC; BRONCHOALVEOLAR LAVAGE FLUID; ELECTROCARDIOGRAPHY; EQUIPMENT DESIGN; HEART RATE; INHALATION EXPOSURE; LUNG; MALE; OZONE; PARTICLE SIZE; PARTICULATE MATTER; RATS; SEASONS; TOXICITY TESTS; WEATHER;

EID: 84928789767     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-015-0087-3     Document Type: Article

References (56)

1. Bell ML, Dominici F, Ebisu K, Zeger SL, Samet KM. Spatial and temporal variation in PM2.5 chemical composition in the United States for health effects studies. Environ Health Perspect. 2007;115:989-95.
2. Bell ML, Ebisu K, Peng RD, Walker J, Samet JM, Zeger SL, et al. Seasonal and regional short-term effects of fine particles on hospital admissions in 202 US Counties, 1999-2005. Am J Epidemiol. 2008;168:1301-10.
3. Goldberg MS, Burnett RT, Valois MF, Flegel K, Bailar III JC, Brook J, et al. Associations between ambient air pollution and daily mortality among persons with congestive heart failure. Environ Res. 2003;91:8-20.
4. Plummer LE, Ham W, Kleeman MJ, Wexler A, Pinkerton KE. Influence of season and location on pulmonary response to California's San Joaquin Valley airborne particulate matter. J Toxicol Environ Health A. 2012;75(5):253-71.
5. Tablin F, den Hartigh LJ, Aung HH, Lame MW, Kleeman MJ, Ham W, et al. Seasonal influences on CAPs exposures: differential responses in platelet activation, serum cytokines and xenobiotic gene expression. Inhal Toxicol. 2012;24(8):506-17.
6. Happo MS, Hirvonen MR, Hälinen AI, Jalava PI, Pennanen AS, Sillanpää M, et al. Seasonal variation in chemical composition of size-segregated urban air particles and the inflammatory activity in the mouse lung. Inhal Toxicol. 2010;22(1):17-32.
7. Becker S, Dailey LA, Soukup JM, Grambow SC, Devlin RB, Huang YC. Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. Environ Health Perspect. 2005;113(8):1032-8.
8. Happo M, Markkanen A, Markkanen P, Jalava P, Kuuspalo K, Leskinen A, et al. Seasonal variation in the toxicological properties of size-segregated indoor and outdoor air particulate matter. Toxicol In Vitro. 2013;7(5):1550-61.
9. Mauderly JL, Samet JM. Is there evidence for synergy among air pollutants in causing health effects? Environ Health Perspect. 2009;117(1):1-6.
10. Fakhri AA, Ilic LM, Wellenius GA, Urch B, Silverman F, Gold DR, et al. Autonomic effects of controlled fine particulate exposure in young health adults: effect modification by ozone. Environ Health Perspect. 2009;117(8):1287-92.
11. Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, et al. The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers. J Am Coll Cardiol. 2011;57(2):198-206.
12. Wagner JG, Allen K, Yang HY, Nan B, Morishita M, Mukherjee B, et al. Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: effects of diet-induced metabolic syndrome. Environ Health Perspect. 2014;122:27-33.
13. Sun L, Liu C, Xu X, Ying Z, Maiseyeu A, Wang A, et al. Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet. Part Fibre Toxicol. 2013;10:43.
14. Aneja VP, Wang B, Tong DQ, Kimball H, Steger J. Characterization of major chemical components of fine particulate matter in North Carolina. J Air Waste Manag Assoc. 2006;56(8):1099-107.
15. Carll AP, Lamb C, Hazari MS, Winsett DW, Krantz QT, Costa DL KC, et al. Whole and particle-free diesel exhausts differentially affect cardiac electrophysiology, blood pressure, and autonomic balance in heart failure-prone rats. Toxicol Sci. 2012;128:490-9.
16. Farraj AK, Hazari MS, Winsett DW, Kulukulualani A, Carll AP, Haykal-Coates N, et al. Overt and Latent Cardiac Effects of Ozone Inhalation in Rats: Evidence for Autonomic Modulation and Increased Myocardial Vulnerability. Environ Health Perspect. 2012;120:348-54.
17. Hazari MS, Haykal-Coates N, Winsett DW, Costa DL, Farraj AK. A single exposure to particulate or gaseous air pollution increases the risk of aconitine-induced cardiac arrhythmia in hypertensive rats. Toxicol Sci. 2009;112(2):532-42.
18. Lamb CM, Hazari MS, Haykal-Coates N, Carll AP, Krantz QT, King C, et al. Divergent electrocardiographic responses to whole and particle-free diesel exhaust inhalation in spontaneously hypertensive rats. Toxicol Sci. 2012;125:558-68.
19. US EPA, 2004. EPA-CMB8.2 User's Manual. EPA-452/R-04-011. Research Triangle Park, NC.
20. Farraj AK, Haykal-Coates N, Winsett DW, Hazari MS, Carll AP, Rowan III WH, et al. Increased Non-conducted P-wave arrhythmias after a single Oil Fly Ash inhalation exposure in hypertensive rats. Environ Health Perspect. 2009;117(5):709-15.
21. Farraj AK, Hazari MS, Haykal-Coates N, Lamb C, Winsett DW, Ge Y, et al. ST depression, arrhythmia, vagal dominance, and reduced cardiac micro-RNA in particulate-exposed rats. Am J Respir Cell Mol Biol. 2011;44(2):185-96.
22. Hazari MS, Haykal-Coates N, Winsett DW, Krantz QT, King C, Costa DL, et al. TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust. Environ Health Perspect. 2011;119(7):951-7.
23. Boman BC, Forsberg AB, Järvholm BG. Adverse health effects from ambient air pollution in relation to residential wood combustion in modern society. Scand J Work Environ Health. 2003;29(4):251-60.
24. Boman BC, Nordin A, Boström D, Öhman M. Characterization of inorganic particulate matter from residential combustion of pelletized biomass fuels. Energ Fuels. 2004;18:338-48.
25. Ostro B, Feng W-Y, Broadwin R, Green S, Lipsett M. The effects of components of fine particulate air pollution on mortality in California: results from CALFINE. Environ Health Perspect. 2007;114:13-9.
26. Ghio AJ, Devlin RB. Inflammatory lung injury after bronchial instillation of air pollution particles. Am J Respir Crit Care Med. 2001;164(4):704-8.
27. Huang YC, Ghio AJ, Stonehuerner J, McGee J, Carter JD, Grambow SC, et al. The role of soluble components in ambient fine particles-induced changes in human lungs and blood. Inhal Toxicol. 2003;15(4):327-42.
28. Kodavanti UP, Schladweiler MC, Ledbetter AD, McGee JK, Walsh L, Gilmour PS, et al. Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: roles of rat strains used and physicochemical properties. Environ Health Perspect. 2005;113(11):1561-8.
29. Brook RD, Rajagopalan S, Pope III CA, Brook JR, Bhatnagar A, Diez-Roux AV, et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010;121:2331-78.
30. Cho SH, Tong H, McGee JK, Baldauf RW, Krantz QT, Gilmour MI. Comparative toxicity of size-fractionated airborne particulate matter collected at different distances from an urban highway. Environ Health Perspect. 2009;117(11):1682-9.
31. Kim YH, Tong H, Daniels M, Boykin E, Krantz QT, McGee J, et al. Cardiopulmonary toxicity of peat wildfire particulate matter and the predictive utility of precision cut lung slices. Part Fibre Toxicol. 2014;11:29.
32. Rohr AC, Kamal A, Morishita M, Mukherjee B, Keeler GJ, Harkema JR, et al. Altered heart rate variability in spontaneously hypertensive rats is associated with specific particulate matter components in Detroit, Michigan. Environ Health Perspect. 2011;119:474-80.
33. Chuang K-J, Chan C-C, Chen N-T, Su T-C, Lin L-Y. Effects of particle size fractions on reducing heart rate variability in cardiac and hypertensive patients. Environ Health Perspect. 2005;113:1693-7.
34. Muggenburg BA, Barr EB, Cheng YS, Seagrave JC, Tilley LP, Mauderley JL. Effect of inhaled residual oil fly ash on the electrocardiogram of dogs. Inhal Toxicol. 2000;12 Suppl 4:189-208.
35. Schulz H, Harder V, Ibald-Mulli A, Khandoga A, Koenig W, Krombach F, et al. Cardiovascular effects of fine and ultrafine particles. J Aeros Med. 2005;18(1):1-22.
36. Vallejo M, Ruiz S, Hermosillo AG, Borja-Aburto VH, Cardenas M. Ambient fine particles modify heart rate variability in young healthy adults. J Expos Sci Environ Epid. 2006;16:125-30.
37. Schwartz J, Litonjua A, Suh H, Verrier M, Zanobetti A, Syring M, et al. Traffic related pollution and heart rate variability in a panel of elderly subjects. Thorax. 2005;60(6):455-61.
38. Zanobetti A, Gold DR, Stone PH, Suh HH, Schwartz J, Coull BA, et al. Reduction in heart rate variability with traffic and air pollution in patients with coronary artery disease. Environ Health Perspect. 2010;118(3):324-30.
39. Corey LM, Baker C, Luchtel DL. Heart-rate variability in the Apo lipoprotein E knockout transgenic mouse following exposure to Seattle particulate matter. J Toxicol Environ Health Part A. 2006;69:953-65.
40. Bigger Jr JT, Fleiss JL, Rolnitzky LM, Steinman RC. Frequency domain measures of heart period variability to assess risk late after myocardial infarction. J Am Coll Cardiol. 1993;21:729-36.
41. Fauchier L, Babuty D, Melin A, Bonnet P, Cosnay P, Fauchier JP. Heart rate variability in severe right or left heart failure: the role of pulmonary hypertension and resistances. Eur J Heart Failure. 2004;1(6):181-5.
42. Taylor-Clark TE, Undem BJ. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol. 2010;588(3):423-33.
43. Takahashi N, Mori Y. TRP channels as sensors and signal integrators of redox status changes. Front Pharmacol. 2011;2:58.
44. Costa DL: Air Pollution. In Casarett & Doull's Toxicology: The Basic Science of Poison. 6th edition. Edited by Klaassen CD. New York: McGraw-Hill Companies, Inc; 2001:979-1012.
45. Perez CM, Hazari MS, Haykal-Coates N, Carll AP, Krantz QT, King C, et al. Hypoxia stress test reveals exaggerated cardiovascular effects in hypertensive rats after exposure to the Air pollutant acrolein. Toxicol Sci. 2013;132:467-77.
46. Carll AP, Lamb C, Hazari MS, Winsett DW, Krantz QT, Costa DL KC, et al. Diesel exhaust inhalation increases cardiac output, bradyarrhythmias, and parasympathetic tone in aged heart failure-prone rats. Toxicol Sci. 2013;131:583-95.
47. Watkinson WP, Campen MJ, Costa DL. Cardiac arrhythmia after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertension. Toxicol Sci. 1998;41:209-16.
48. The READY system: [https://www.arl.noaa.gov/]
49. Sioutas C, Koutrakis P, Burton RM. A technique to expose animals to concentrated fine ambient aerosols. Environ Health Perspect. 1995;103(2):172-7.
50. Gupta T, Demokritou P, Koutrakis P. Development and performance evaluation of a high-volume ultrafine particle concentrator for inhalation toxicological studies. Inhal Toxicol. 2004;16(13):851-62.
51. The NIOSH Manual of Analytical Methods: [http://www.cdc.gov/niosh/docs/2003-154/pdfs/5040.pdf].
52. Hildemann LM, Markowski GR, Cass GR. Chemical composition of emissions from urban sources of fine organic aerosol. Environ Sci Technol. 1991;25:744-59.
53. Maykut NN, Lewtas J, Kim E, Larson TV. Source apportionment of PM2.5 at an urban IMPROVE site in Seattle, Washington. Sci Technol. 2003;37:5135-42.
54. Fine PM, Cass GR, Simoneit BRT. Chemical characterization of fine particle emissions from the wood stove combustion of prevalent United States tree species. Environ Eng Sci. 2004;21:705-21.
55. Walker MJA, Curtis MJ, Hearse DJ, Campbell RWF, Janse MJ, Yellon DM, et al. The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion. Cardiovasc Res. 1988;22:447-55.
56. Jaskot RH, Charlet EG, Grose EC, Grady MA, Roycroft JH. An automated analysis of gluthione peroxidase, S-Transferase, and reductase activity in animal tissue. J Anal Tox. 1983;7:86-8.