Divergent electrocardiographic responses to whole and particle-free diesel exhaust inhalation in spontaneously hypertensive rats

Toxicological Sciences

Volumn 125, Issue 2, 2012, Pages 558-568

  Lamb, Christina M ^a   Hazari, Mehdi S ^b   Haykal coates, Najwa ^b   Carll, Alex P ^c   Krantz, Q Todd ^b   King, Charly ^b   Winsett, Darrell W ^b   Cascio, Wayne E ^b   Costa, Daniel L ^d   Farraj, Aimen K ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c University of North Carolina at Chapel Hill   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cardiac; Diesel; Electrophysiology; Exhaust; Gases; SH rat

Indexed keywords

CAPSAICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR CONDUCTION; BLOOD PRESSURE; BRADYCARDIA; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; ELECTROCARDIOGRAPHY MONITORING; EXHAUST GAS; HEART ELECTROPHYSIOLOGY; HEART RATE VARIABILITY; HEART REPOLARIZATION; MALE; NONHUMAN; PARTICULATE MATTER; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; ST SEGMENT DEPRESSION; TELEMETRY; WISTAR KYOTO RAT;

RATTUS;

EID: 84856112753     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr296     Document Type: Article

References (38)

1. Anselme, F., Loriot, S., Henry, J. P., Dionnet, F., Napoleoni, J. G., Thuillez, C., and Morin, J. P. (2007). Inhalation of diluted diesel engine emission impacts heart rate variability and arrhythmia occurrence in a rat model of chronic ischemic heart failure. Arch. Toxicol. 81, 299-307.
2. Berger, A., Zareba, W., Schneider, A., Rückerl, R., Ibald-Mulli, A., Cyrys, J., Wichmann, H. E., and Peters, A. (2006). Runs of ventricular and supraventricular tachycardia triggered by air pollution in patients with coronary heart disease. J. Occup. Environ. Med. 48, 1149-1158.
3. Bernardo, B. C., Weeks, K. L., Pretorius, L., and McMullen, J. R. (2010). Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies. Pharmacol. Ther. 128, 191-227.
4. Brook, R. D., and Rajagopalan, S. (2009). Particulate matter, air pollution, and blood pressure. J. Am. Soc. Hypertens. 3, 332-350.
5. Brook, R. D., Rajagopalan, S., Pope, C. A., III, Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010). Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 121, 2331-2378.
6. Campen, M. J., Babu, N. S., Helms, G. A., Pett, S., Wernly, J., Mehran, R., and McDonald, J. D. (2005). Nonparticulate components of diesel exhaust promote constriction in coronary arteries from ApoE-/- mice. Toxicol. Sci. 88, 95-102.
7. Carll, A. P., Haykal-Coates, N., Winsett, D.W., Rowan, W. H., III, Hazari, M. S., Ledbetter, A. D., Nyska, A., Cascio, W. E., Watkinson, W. P., Costa, D. L., et al. (2010). Particulate matter inhalation exacerbates cardiopulmonary injury in a rat model of isoproterenol-induced cardiomyopathy. Inhal. Toxicol. 22, 355-368.
8. Dockery, D. W., Luttmann-Gibson, H., Rich, D. Q., Link, M. S., Mittleman, M. A., Gold, D. R., Koutrakis, P., Schwartz, J. D., and Verrier, R. L. (2005). Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators. Environ. Health Perspect. 113, 670-674.
9. El-Mas, M. M., and Abdel-Rahman, A. A. (2005). Longitudinal studies on the effect of hypertension on circadian hemodynamic and autonomic rhythms in telemetered rats. Life Sci. 76, 901-915.
10. Farraj, A. K., Haykal-Coates, N., Winsett, D. W., Hazari, M. S., Carll, A. P., Rowan, W. H., Ledbetter, A. D., Cascio, W. E., and Costa, D. L. (2009). Increased non-conducted P-wave arrhythmias after a single oil fly ash inhalation exposure in hypertensive rats. Environ. Health Perspect. 117, 709-715.
11. Farraj, A. K., Hazari, M. S., and Cascio, W. E. (2011a). The utility of the small rodent electrocardiogram in toxicology. Toxicol. Sci. 121, 11-30.
12. Farraj, A. K., Hazari, M. S., Haykal-Coates, N., Lamb, C., Winsett, D. W., Ge, Y., Ledbetter, A. D., Carll, A. P., Bruno, M., Ghio, A., et al. (2011b). ST depression, arrhythmia, vagal dominance, and reduced cardiac micro-RNA in particulate-exposed rats. Am. J. Respir. Cell Mol. Biol. 44, 185-196.
13. Ghio, A. J., Suliman, H. B., Carter, J. D., Abushamaa, A. M., and Folz, R. J. (2002). Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash. Am. J. Physiol. Lung Cell Mol. Physiol. 283, 211-218.
14. Gold, D. R., Litonjua, A. A., Zanobetti, A., Coull, B. A., Schwartz, J., MacCallum, G., Verrier, R. L., Nearing, B. D., Canner, M. J., Suh, H., et al. (2005). Air pollution and ST-segment depression in elderly subjects. Environ. Health Perspect. 113, 883-887.
15. Goltz, D., Schultz, J. H., Stucke, C., Wagner, M., Bassalaý, P., Schwoerer, A. P., Ehmke, H., and Volk, T. (2007). Diminished Kv4.2/3 but not KChIP2 levels reduce the cardiac transient outward K+ current in spontaneously hypertensive rats. Cardiovasc. Res. 74, 85-95.
16. Harkema, J. R., Wagner, J. G., Kaminski, N. E., Morishita, M., Keeler, G. J., McDonald, J. D., and Barrett, E. G. (2009). Effects of concentrated ambient particles and diesel engine exhaust on allergic airway disease in Brown Norway rats. Res. Rep. Health Eff. Inst. 145, 5-55.
17. Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Costa, D. L., and Farraj, A. K. (2009). A single exposure to particulate or gaseous air pollution increases the risk of aconitine-induced cardiac arrhythmia in hypertensive rats. Toxicol. Sci. 112, 532-542.
18. Hazari, M. S., Rowan, W. H., Winsett, D. W., Ledbetter, A. D., Haykal-Coates, N., Watkinson, W. P., and Costa, D. L. (2008). Potentiation of pulmonary reflex response to capsaicin 24h following whole-body acrolein exposure is mediated by TRPV1. Respir. Physiol. Neurobiol. 160, 160-171.
19. Henneberger, A., Zareba, W., Ibald-Mulli, A., Rückerl, R., Cyrys, J., Couderc, J. P., Mykins, B., Woelke, G., Wichmann, H. E., and Peters, A. (2005). Repolarization changes induced by air pollution in ischemic heart disease patients. Environ. Health Perspect. 113, 440-446.
20. Hoek, G., Brunekreef, B., Goldbohm, S., Fischer, P., and van den Brandt, P. A. (2002). Association between mortality and indicators of traffic related air pollution in the Netherlands: A cohort study. Lancet 360, 1203-1209.
21. Hoffmann, B., Moebus, S., Stang, A., Beck, E.M., Dragano, N., Möhlenkamp, S., Schmermund, A., Memmesheimer, M., Mann, K., Erbel, R., et al. (2006). Residence close to high traffic and prevalence of coronary heart disease. Eur. Heart J. 27, 2696-2702.
22. Kamm, S., Möhler, O., Naumann, K. H., Saathoff, H., and Schurath, U. (1999). The heterogeneous reaction of ozone with soot aerosol. Atmos. Environ. 33, 4651-4661.
23. Le Tertre, A., Medina, S., Samoli, E., Forsberg, B., Michelozzi, P., Boumghar, A., Vonk, J. M., Bellini, A., Atkinson, R., Ayres, J. G., et al. (2002). Short-term effects of particulate air pollution on cardiovascular diseases in eight European cities. J. Epidemiol. Community Health 56, 773-779.
24. Mills, N. L., Finlayson, A. E., Gonzalez, M. C., Törnqvist, H., Barath, S., Vink, E., Goudie, C., Langrish, J. P., Söderberg, S., Boon, N. A., et al. (2011a). Diesel exhaust inhalation does not affect heart rhythm or heart rate variability. Heart 97, 544-550.
25. Mills, N. L., Miller, M. R., Lucking, A. J., Beveridge, J., Flint, L., Boere, A. J., Fokkens, P. H., Boon, N. A., Sandstrom, T., Blomberg, A., et al. (2011b). Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation. Eur. Heart J. 32, 2600-2671.
26. Mills, N. L., Törnqvist, H., Gonzalez, M. C., Vink, E., Robinson, S. D., Söderberg, S., Boon, N. A., Donaldson, K., Sandström, T., Blomberg, A., et al. (2007). Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N. Engl. J. Med. 357, 1075-1082.
27. Mulvany, M. J., and Halpern, W. (1977). Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41, 19-26.
28. Pekkanen, J., Peters, A., Hoek, G., Tiittanen, P., Brunekreef, B., de Hartog, J., Heinrich, J., Ibald-Mulli, A., Kreyling, W. G., Lanki, T., et al. (2002). Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease: The Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) study. Circulation 106, 933-938.
29. Peters, A., von Klot, S., Heier, M., Trentinaglia, I., Hörmann, A., Wichmann, H. E., and Löwel, H. (2004). Exposure to traffic and the onset of myocardial infarction. N. Engl. J. Med. 351, 1721-1730.
30. Ris, C. (2007). U.S. EPA health assessment for diesel engine exhaust: A review. Inhal. Toxicol. 1, 229-239.
31. Sapire, D. W., Shah, J. J., and Black, I. F. (1979). Prolonged atrioventricular conduction in young children and adolescents. The role of increased vagal tone. S. Afr. Med. J. 55, 669-763.
32. Sosnowski, T. R., Koliński, M., and Gradón, L. (2011). Interactions of benzo[a]pyrene and diesel exhaust particulate matter with the lung surfactant system. Ann. Occup. Hyg. 55, 329-338.
33. U.S. EPA. Health Assessment Document for Diesel Engine Exhaust. (2002). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, EPA/600/8-90/057F.
34. Van Hee, V. C., Adar, S. D., Szpiro, A. A., Barr, R. G., Bluemke, D. A., Diez Roux, A. V., Gill, E. A., Sheppard, L., and Kaufman, J. D. (2009). Exposure to traffic and left ventricular mass and function: The Multi-Ethnic Study of Atherosclerosis. Am. J. Respir. Crit. Care Med. 179, 827-834.
35. Walker, M. J., Curtis, M. J., Hearse, D. J., Campbell, R. W., Janse, M. J., Yellon, D. M., Cobbe, S. M., Coker, S. J., Harness, J. B., Harron, D. W., et al. (1988). The Lambeth Conventions: Guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion. Cardiovasc. Res. 22, 447-455.
36. Watkinson, W. P., Wiester, M. J., and Highfill, J. W. (1995). Ozone toxicity in the rat. I. Effect of changes in ambient temperature on extrapulmonary physiological parameters. J. Appl. Physiol. 78, 1108-1120.
37. Zanobetti, A., Canner, M. J., Stone, P. H., Schwartz, J., Sher, D., Eagan-Bengston, E., Gates, K. A., Hartley, L. H., Suh, H., and Gold, D. R. (2004). Ambient pollution and blood pressure in cardiac rehabilitation patients. Circulation 110, 2184-2189.
38. Zhu, Y., Hinds, W. G., Kim, S., Shen, S., and Sioutas, C. (2002). Study of ultrafine particles near a major highway with heavy-duty diesel traffic. Atmos. Environ. 36, 4323-4335.