Altered heart rate variability in spontaneously hypertensive rats is associated with specific particulate matter components in Detroit, Michigan

Environmental Health Perspectives

Volumn 119, Issue 4, 2011, Pages 474-480

  Rohr, Annette C ^a   Kamal, Ali ^b,d   Morishita, Masako ^b   Mukherjee, Bhramar ^b   Keeler, Gerald J ^b   Harkema, Jack R ^c   Wagner, James G ^c  

^a ELECTRIC POWER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Air pollution; Cardiac function; Heart rate variability; Particulate matter; Toxicology

Indexed keywords

AMMONIA; ANTIMONY; ARSENIC; BARIUM; CADMIUM; CALCIUM; CALCIUM OXIDE; CARBON; CEMENT; CHROMIUM; COAL; COPPER; GASOLINE; IRON; LANTHANUM; LEAD; MAGNESIUM; MANGANESE; NITRATE; POTASSIUM; RUBIDIUM; SELENIUM; STEEL; STRONTIUM; SULFATE; SULFUR; TITANIUM; ZINC;

AIR POLLUTANT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYCARDIA; CHEMICAL COMPOSITION; ECOTOXICITY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; HEART RATE VARIABILITY; INCINERATION; MALE; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; RISK FACTOR; SEASONAL VARIATION; SPONTANEOUSLY HYPERTENSIVE RAT; TACHYCARDIA; UNITED STATES;

AIR POLLUTANTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL MONITORING; HEART RATE; HYPERTENSION; MALE; MICHIGAN; PARTICULATE MATTER; RATS;

RATTUS;

EID: 79955552307     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002831     Document Type: Article

References (28)

1. Batalha JR, Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, et al. 2002. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environ Health Perspect 110:1191-1197.
2. Becker S, Dailey LA, Soukup JM, Grambow SC, Devlin RB, Huang Y-CT. 2005. Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. Environ Health Perspect 113:1032-1038.
3. Blanchard CL, Hidy GM, Tanenbaum S, Edgerton E, Hartsell B, Jansen J. 2008. Carbon in southeastern U.S. aerosol particles: empirical estimates of secondary organic aerosol formation. Atmos Environ 42:6710-6720.
4. Chen LC, Hwang JS. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart-rate variability. Inhal Toxicol 17:209-216.
5. 2.5. Inhal Toxicol 22(7):580-592.
6. Garg BD, Cadle SH, Mulawa PA, Groblicki PJ, Laroo C, Parr GA. 2000. Brake wear particulate matter emissions. Environ Sci Technol 34:4463-4469.
7. Gurgueira SA, Lawrence J, Coull B, Murthy GG, Gonzalez-Flecha B. 2002. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ Health Perspect 110:749-755.
8. Harkema JR, Wagner JG, Kaminski NE, Morishita M, Keeler GJ, McDonald JD, et al. 2009. Effects of concentrated ambient particles and diesel engine exhaust on allergic airway disease in Brown Norway rats. Res Rep Health Eff Inst (145):5-55.
9. Keeler GJ, Morishita M, Young LH. 2005. Characterization of complex mixtures in urban atmospheres for inhalation exposure studies. Exp Toxicol Pathol 57:19-29.
10. Kidwell CB, Ondov JM. 2001. Development and evaluation of a prototype system for collecting sub-hourly ambient aerosol for chemical analysis. Aerosol Sci Technol 35:596-601.
11. Kidwell CB, Ondov JM. 2004. Elemental analysis of sub-hourly ambient aerosol collections. Aerosol Sci Technol 38:205-218.
12. Kodavanti UP, Schladweiler MC, Ledbetter AD, McGee JK, Walsh L, Gilmour PS, et al. 2005. Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: roles of rat strains used and physicochemical properties. Environ Health Perspect 113:1561-1568.
13. Lanki T, de Hartog JJ, Heinrich J, Hoek G, Janssen NA, Peters A, et al. 2006. Can we identify sources of fine particles responsible for exercise-induced ischemia on days with elevated air pollution? The ULTRA study. Environ Health Perspect 114:655-660.
14. Lippmann M, Hwang JS, Maciejczyk P, Chen LC. 2005. PM source apportionment for short-term cardiac function changes in ApoE-/-mice. Environ Health Perspect 113:1575-1579.
15. Lippmann M, Ito K, Hwang JS, Macieiczyk P, Chen LC. 2006. Cardiovascular effects of nickel in ambient air. Environ Health Perspect 114:1662-1669.
16. 2.5 sources and analysis of pollution episodes in Detroit, Michigan using highly time-resolved measurements. Atmos Environ 45:1627-1637.
17. 2.5 during summer inhalation exposure studies in Detroit, MI. Atmos Environ 40:3823-3834.
18. NIOSH (National Institute for Occupational Safety and Health). 1999. Method 5040: Elemental Carbon (Diesel Particulate). Available: http://www.cdc.gov/niosh/docs/2003-154/pdfs/5040f3.pdf [accessed 1 March 2011].
19. Paatero P, Tapper U. 1994. Positive matrix factorization: a non-negative factor model with optimal utilization of error estimates of data values. Environmetrics 5:111-126.
20. 2.5 in the Pittsburgh region. In: Proceedings of the Air Quality III: Conference. Mercury, Trace Elements, and Particulate Matter, Arlington, VA, 9-12 September 2002. Available: http://www.netl.doe.gov/publications/proceedings/02/air_q3/CMU.pdf [accessed 1 March 2011].
21. Rohr AC, Wagner JG, Morishita M, Kamal A, Keeler GJ, Harkema JR. 2010. Cardiopulmonary responses in spontaneously hypertensive and Wistar-Kyoto rats exposed to concentrated ambient particles from Detroit, Michigan. Inhal Toxicol 22:522-523.
22. Rowan WH III, Campen MJ, Wichers LB, Watkinson WP. 2007. Heart rate variability in rodents: uses and caveats in toxicological studies. Cardiovasc Toxicol 7:28-51.
23. Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GG, et al. 2002. Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am J Respir Crit Care Med 165:1610-1617.
24. Sarnat JA, Marmur A, Klein M, Kim E, Russell AG, Sarnat SE, et al. 2008. Fine particle sources and cardiorespiratory morbidity: an application of chemical mass balance and factor analytical source apportionment methods. Environ Health Perspect 116:459-466.
25. Schauer JJ, Lough GC, Shafer MM, Christensen WF, Arndt MF, DeMinter JT, et al. 2006. Characterization of Metals Emitted from Motor Vehicles. Research Rep. 133. Boston:Health Effects Institute.
26. Schwartz J, Litonjua A, Suh H, Verrier M, Zanobetti A, Syring M, et al. 2006. Traffic related pollution and heart rate variability in a panel of elderly subjects. Thorax 60:455-461.
27. Sioutas C, Koutrakis P, Ferguson ST, Burton RM. 1997. Development and evaluation of a prototype ambient particle concentrator for inhalation exposure studies. Inhal Toxicol 7:633-644.
28. U.S. EPA (U.S. Environmental Protection Agency). 2010. EPA Positive Matrix Factorization (PMF) 3.0 Model. Available: http://www.epa.gov/heasd/products/pmf/pmf.html [accessed 23 February 2011].