Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: Roles of rat strains used and physicochemical properties

Environmental Health Perspectives

Volumn 113, Issue 11, 2005, Pages 1561-1568

  Kodavanti, Urmila P ^a   Schladweiler, Mette C ^a   Ledbetter, Allen D ^a   McGee, John K ^a   Walsh, Leon ^a   Gilmour, Peter S ^b   Highfill, Jerry W ^a   Davies, David ^a   Pinkerton, Kent E ^c   Richards, Judy H ^a   Crissman, Kay ^a   Andrews, Debora ^a   Costa, Daniel L ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

glutamyltransferase; Concentrated ambient particles; Fibrinogen; Hypertensive rats; Lung inflammation; Macrophages; Neutrophils; Wistar Kyoto rats

Indexed keywords

ALUMINUM; COPPER; FIBRINOGEN; GAMMA GLUTAMYLTRANSFERASE; ORGANIC CARBON; SULFATE; ZINC;

AIRBORNE PARTICLE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; EXPIRATORY FLOW; FIBRINOGEN BLOOD LEVEL; FILTRATION; INHALATION; INSPIRATORY CAPACITY; LONG TERM EXPOSURE; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; LUNG FLUID; LUNG LAVAGE; LUNG TOXICITY; MALE; NEUTROPHIL; NONHUMAN; PARTICULATE MATTER; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; RAT STRAIN; SPONTANEOUSLY HYPERTENSIVE RAT; STATISTICAL SIGNIFICANCE; TOXICITY TESTING;

AIR POLLUTANTS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CARBON; DUST; FIBRINOGEN; GAMMA-GLUTAMYLTRANSFERASE; LUNG; MACROPHAGES; MALE; METALS; NEUTROPHILS; PARTICLE SIZE; PULMONARY VENTILATION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SPECIES SPECIFICITY; SULFATES;

ANIMALIA; RODENTIA;

EID: 27744573323     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.7868     Document Type: Article

References (27)

1. Andrews E, Saxena P, Musarra S, Hildemann LM, Koutrakis P, McMurry PH, et al. 2000. Concentration and composition of atmospheric aerosols from the 1995 SEAVS experiment and a review of the closure between chemical and gravimetric measurements. J Air Waste Manage Assoc 50:648-664.
2. Bianchi G, Ferrari P, Cusi D, Salardi S, Guidi E, Niutta E, et al. 1986. Genetic and experimental hypertension in the animal model-similarities and dissimilarities to the development of human hypertension. J Cardiovasc Pharmacol 8:S64-S70.
3. Carvalho-Oliveira R, Pozo RM, Lobo DJ, Lichtenfels AJ, Martins-Junior HA, Bustilho JO, et al. 2005. Diesel emissions significantly influence composition and mutagenicity of ambient particles: a case study in Sao Paulo, Brazil. Environ Res 98:1-7.
4. Clarke RW, Catalano PJ, Koutrakis P, Krishna Murthy GG, Sioutas C, Paulauskis SJ, et al. 1999. Urban air particulate inhalation alters pulmonary function and induces pulmonary inflammation in a rat model of chronic bronchitis. Inhal Toxicol 11:637-656.
5. Clarke RW, Coull B, Reinisch U, Catalano P, Killingsworth CR, Koutrakis P, et al. 2000. Inhaled concentrated ambient particles are associated with hematological and bronchoalveolar lavage changes in canines. Environ Health Perspect 108: 1179-1187.
6. Dye JA, Adler KB, Richards JH, Dreher KL. 1999. Role of soluble metals in oil fly ash-induced airway epithelial injury and cytokine gene expression. Am J Physiol 277:L498-L510.
7. 2, carbon black, and coal dust and the influence of poly-2-vinylpyridine-N-oxide (PVNO). Exp Toxicol Pathol 54:109-126.
8. Gardner SY, Lehmann JR, Costa DL. 2000. Oil fly ash-induced elevation of plasma fibrinogen levels in rats. Toxicol Sci 56:175-180.
9. Ghio AJ, Hall A, Bassett MA, Cascio WE, Devlin RB. 2003. Exposure to concentrated ambient air particles alter hematologic indices in humans. Inhal Toxicol 15:1465-1478.
10. Ghio AJ, Kim C, Devlin RB. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Respir Crit Care Med 162:981-988.
11. Gilmour PS, Schladweiler MC, Richards JH, Ledbetter AD, Kodavanti UP. 2004. Hypertensive rats are susceptible to TLR4-mediated signaling following exposure to combustion source particulate matter. Inhal Toxicol 16(suppl 1):5-18.
12. Gordon T, Gerber H, Fang CP, Chen LC. 1999. A centrifugal particle concentrator for use in inhalation toxicology. Inhal Toxicol 11:71-87.
13. Gordon T, Nadziejko C, Chen LC, Schlesinger R. 2000. Effects of concentrated ambient particles in rats and hamsters: an exploratory study. Res Rep Health Eff Inst 93:5-34.
14. Harrison RM, Yin J. 2000. Particulate matter in the atmosphere: which particle properties are important for its effects on health? Sci Total Environ 249:85-101.
15. Huang YC, Ghio AJ, Stonehuerner J, McGee J, Carter JD, Grambow SC, et al. 2003. The role of soluble components in ambient fine particles-induced changes in human lungs and blood. Inhal Toxicol 15:327-342.
16. Kodavanti UP, Hauser R, Christiani DC, Meng ZH, McGee J, Ledbetter A, et al. 1998. Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicol Sci 43:204-212.
17. Kodavanti UP, Mebane R, Ledbetter A, Krantz T, McGee J, Jackson MC, et al. 2000a. Variable pulmonary responses from exposure to concentrated ambient air particles in a rat model of bronchitis. Toxicol Sci 54:441-451.
18. Kodavanti UP, Schladweiler MC, Ledbetter AD, Hauser R, Christiani DC, McGee J, et al. 2002. Temporal association between pulmonary and systemic effects of particulate matter in healthy and cardiovascular compromised rats. J Toxicol Environ Health A 65:1545-1569.
19. Kodavanti UP, Schladweiler MC, Ledbetter AD, Watkinson WP, Campen MJ, Winsett DW, et al. 2000b. The spontaneously hypertensive rat as a model of human cardiovascular disease: evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matter. Toxicol Appl Pharmacol 164:250-263.
20. McGee JK, Chen LC, Cohen MD, Chee GR, Prophete CM, Haykal-Coates N, et al. 2003. Chemical analysis of World Trade Center fine particulate matter for use in toxicologic assessment. Environ Health Perspect 111:972-980.
21. NOAH. 2004. Air Resources Laboratory. Washington,DC:National Oceanic and Atmospheric Administration. Available: http://www.arl.noaa.gov/ready/ [accessed 1 October 2004].
22. Saldiva PH, Clarke RW, Coull BA, Stearns RC, Lawrence J, Murthy GG, et al. 2002. Lung inflammation induced by concentrated ambient particles is related to particle composition. Am J Respir Crit Care Med 165:1610-1617.
23. Sioutas C, Koutrakis P, Burton RM. 1995. A technique to expose animals to concentrated fine ambient aerosols. Environ Health Perspect 103:172-177.
24. Smith KR, Kim S, Recendez JJ, Teague SV, Menache MG, Grubbs DE, et al. 2003. Airborne particles of the California central valley alter the lungs of healthy adult rats. Environ Health Perspect 111:902-908.
25. Tankersley CG, Fitzgerald RS, Levitt RC, Mitzner WA, Ewart SL, Kleebergeer SR. 1997. Genetic control of differential baseline breathingb pattern. J Appl Physiol 82:874-881.
26. Turpine BJ, Saxena P, Andrews E. 2000. Measuring and simulating particulate organics in the atmosphere: problems and prospects. Atmos Environ 34:2983-3013.
27. 2.5 chemical constituents to acute arterial vasoconstriction in humans. Inhal Toxicol 16:345-352.