New drugs from ancient natural foods. Oleocanthal, the natural occurring spicy compound of olive oil: A brief history

Drug Discovery Today

Volumn 20, Issue 4, 2015, Pages 406-410

  Scotece, Morena ^a   Conde, Javier ^a   Abella, Vanessa ^a,b   Lopez, Veronica ^a   Pino, Jesús ^c   Lago, Francisca ^a   Smith, Amos B ^d,e   Gómez Reino, Juan J ^a,f   Gualillo, Oreste ^a  

^a Santiago University Clinical Hospital   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

^c Instituto de Salud Carlos III   (Spain)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e MONELL CHEMICAL SENSES CENTER   (United States)

^f UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; NOOTROPIC AGENT; OLEOCANTHAL; OLIVE OIL; PHENOL DERIVATIVE; UNCLASSIFIED DRUG; ALDEHYDE;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; CHEMOPROPHYLAXIS; DEGENERATIVE DISEASE; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; FOOD; HISTORY; HUMAN; NONHUMAN; REVIEW; SPICE; ANIMAL; CHEMISTRY; FRUIT; ISOLATION AND PURIFICATION; MEDICINAL PLANT; OLIVE TREE; PHYTOTHERAPY;

ALDEHYDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; FRUIT; HISTORY, 21ST CENTURY; HISTORY, ANCIENT; HUMANS; OLEA; OLIVE OIL; PHENOLS; PHYTOTHERAPY; PLANTS, MEDICINAL; SPICES;

EID: 84928786277     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.10.017     Document Type: Short Survey

References (34)

1. R. Colomer, and J.A. Menendez Mediterranean diet, olive oil and cancer Clin. Transl. Oncol. 8 2006 15 21
2. 2 J. Agric. Food Chem. 52 2004 2866 2874
3. M.C. Maiuri Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation Naunyn Schmiedebergs Arch. Pharmacol. 371 2005 457 465
4. A. Petroni Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil Thromb. Res. 78 1995 151 160
5. C. Ramassamy Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets Eur. J. Pharmacol. 545 2006 51 64
6. P. Andrewes Sensory properties of virgin olive oil polyphenols: identification of deacetoxy-ligstroside aglycon as a key contributor to pungency J. Agric. Food Chem. 51 2003 1415 1420
7. - (2011) EFSA J. 9, 2033
8. G. Montedoro Simple and hydrolyzable compounds in virgin olive oil, 3. Spectroscopic characterizations of the secoiridoid derivatives J. Agric. Food Chem. 41 1993 2228 2234
9. G.K. Beauchamp Phytochemistry: ibuprofen-like activity in extra-virgin olive oil Nature 437 2005 45 46
10. A.B. Smith III Synthesis and assignment of absolute configuration of (-)-oleocanthal: a potent, naturally occurring non-steroidal anti-inflammatory and anti-oxidant agent derived from extra virgin olive oils Org. Lett. 7 2005 5075 5078
11. A.B. Smith III Syntheses of (-)-oleocanthal, a natural NSAID found in extra virgin olive oil, the (-)-deacetoxy-oleuropein aglycone, and related analogues J. Org. Chem. 72 2007 6891 6900
12. A. Iacono Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line Arthritis Rheum. 62 2010 1675 1682
13. M. Scotece Further evidence for the anti-inflammatory activity of oleocanthal: inhibition of MIP-1alpha and IL-6 in J774 macrophages and in ATDC5 chondrocytes Life Sci. 91 2012 1229 1235
14. M. Scotece Oleocanthal inhibits proliferation and MIP-1alpha expression in human multiple myeloma cells Curr. Med. Chem. 20 2013 2467 2475
15. J. Pitt Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal Toxicol. Appl. Pharmacol. 240 2009 189 197
16. J.L. Busch Biosensor measurements of polar phenolics for the assessment of the bitterness and pungency of virgin olive oil J. Agric. Food Chem. 54 2006 4371 4377
17. A.Y. Elnagar (-)-Oleocanthal as a c-Met inhibitor for the control of metastatic breast and prostate cancers Planta Med. 77 2011 1013 1019
18. C. Peyrot des Gachons Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal J. Neurosci. 31 2011 999 1009
19. S.B. Abramson Nitric oxide in inflammation and pain associated with osteoarthritis Arthritis Res. Ther. 10 Suppl. 2 2008 S2
20. A.M. Hodge Foods, nutrients and prostate cancer Cancer Causes Control 15 2004 11 20
21. C. Fortes The protective effect of the Mediterranean diet on lung cancer Nutr. Cancer 46 2003 30 37
22. C. Bosetti Diet and environmental carcinogenesis in breast/gynaecological cancers Curr. Opin. Obstet. Gynecol. 14 2002 13 18
23. A. Trichopoulou Olive oil and breast cancer Cancer Causes Control 6 1995 475 476
24. M. Stoneham Olive oil, diet and colorectal cancer: an ecological study and a hypothesis J. Epidemiol. Community Health 54 2000 756 760
25. P. Khanal p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis Carcinogenesis 32 2011 545 553
26. L. Margarucci Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor Chem. Commun. 49 2013 5844 5846
27. M.R. Akl Olive phenolics as c-Met inhibitors: (-)-oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models PLOS ONE 9 2014 e97622
28. W. Li Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau J. Neurochem. 110 2009 1339 1351
29. M.C. Monti New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component Food Funct. 2 2011 423 428
30. M.C. Monti Modulation of tau protein fibrillization by oleocanthal J. Nat. Prod. 75 2012 1584 1588
31. D. Kuhnke MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer's amyloid-beta peptides: implications for the mechanisms of Abeta clearance at the blood-brain barrier Brain Pathol. 17 2007 347 353
32. J.R. Cirrito P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model J. Clin. Invest. 115 2005 3285 3290
33. A.H. Abuznait Olive-oil-derived oleocanthal enhances beta-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies ACS Chem. Neurosci. 4 2013 973 982
34. R. Estruch Primary prevention of cardiovascular disease with a Mediterranean diet N. Engl. J. Med. 368 2013 1279 1290