메뉴 건너뛰기




Volumn 31, Issue 5, 2015, Pages 232-238

Formation and activation of thermogenic fat

Author keywords

Adaptive thermogenesis; Beige fat; Brown fat; Obesity

Indexed keywords

ADIPONECTIN; CD24 ANTIGEN; CELL SURFACE MARKER; MYOGENIC FACTOR 5; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; UNCOUPLING PROTEIN 1; BIOLOGICAL MARKER; MEMBRANE ANTIGEN;

EID: 84928766717     PISSN: 01689525     EISSN: 13624555     Source Type: Journal    
DOI: 10.1016/j.tig.2015.03.003     Document Type: Review
Times cited : (31)

References (70)
  • 1
    • 84896690513 scopus 로고    scopus 로고
    • Prevalence of childhood and adult obesity in the United States, 2011-2012
    • Ogden C.L., et al. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014, 311:806-814.
    • (2014) JAMA , vol.311 , pp. 806-814
    • Ogden, C.L.1
  • 3
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess A.M., et al. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 2009, 360:1509-1517.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1509-1517
    • Cypess, A.M.1
  • 4
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen K.A., et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 2009, 360:1518-1525.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1
  • 5
    • 64349095231 scopus 로고    scopus 로고
    • Cold-activated brown adipose tissue in healthy men
    • van Marken Lichtenbelt W.D., et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 2009, 360:1500-1508.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1500-1508
    • van Marken Lichtenbelt, W.D.1
  • 6
    • 84892727198 scopus 로고    scopus 로고
    • What we talk about when we talk about fat
    • Rosen E.D., Spiegelman B.M. What we talk about when we talk about fat. Cell 2014, 156:20-44.
    • (2014) Cell , vol.156 , pp. 20-44
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 7
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: development, function and therapeutic potential
    • Harms M., Seale P. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 2013, 19:1252-1263.
    • (2013) Nat. Med. , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 8
    • 84897095375 scopus 로고    scopus 로고
    • Brown fat fuel utilization and thermogenesis
    • Townsend K.L., Tseng Y.H. Brown fat fuel utilization and thermogenesis. Trends Endocrinol. Metab. 2014, 25:168-177.
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 168-177
    • Townsend, K.L.1    Tseng, Y.H.2
  • 9
    • 84874657953 scopus 로고    scopus 로고
    • Characterization of the adipocyte cellular lineage in vivo
    • Berry R., Rodeheffer M.S. Characterization of the adipocyte cellular lineage in vivo. Nat. Cell Biol. 2013, 15:302-308.
    • (2013) Nat. Cell Biol. , vol.15 , pp. 302-308
    • Berry, R.1    Rodeheffer, M.S.2
  • 10
    • 84891867283 scopus 로고    scopus 로고
    • Weighing in on adipocyte precursors
    • Berry R., et al. Weighing in on adipocyte precursors. Cell Metab. 2014, 19:8-20.
    • (2014) Cell Metab. , vol.19 , pp. 8-20
    • Berry, R.1
  • 11
    • 84856954303 scopus 로고    scopus 로고
    • The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells
    • Tran K.V., et al. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 2012, 15:222-229.
    • (2012) Cell Metab. , vol.15 , pp. 222-229
    • Tran, K.V.1
  • 12
    • 33845299821 scopus 로고    scopus 로고
    • Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells
    • Crossno J.T., et al. Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells. J. Clin. Invest. 2006, 116:3220-3228.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3220-3228
    • Crossno, J.T.1
  • 13
    • 68549111150 scopus 로고    scopus 로고
    • Hematopoietic stem cell origin of adipocytes
    • Sera Y., et al. Hematopoietic stem cell origin of adipocytes. Exp. Hematol. 2009, 37:1108-1120.
    • (2009) Exp. Hematol. , vol.37 , pp. 1108-1120
    • Sera, Y.1
  • 14
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 2004, 84:277-359.
    • (2004) Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 15
    • 34347326271 scopus 로고    scopus 로고
    • Transcriptional control of brown fat determination by PRDM16
    • Seale P., et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007, 6:38-54.
    • (2007) Cell Metab. , vol.6 , pp. 38-54
    • Seale, P.1
  • 16
    • 50049122271 scopus 로고    scopus 로고
    • PRDM16 controls a brown fat/skeletal muscle switch
    • Seale P., et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008, 454:961-967.
    • (2008) Nature , vol.454 , pp. 961-967
    • Seale, P.1
  • 17
    • 84864287504 scopus 로고    scopus 로고
    • Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
    • Wu J., et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012, 150:366-376.
    • (2012) Cell , vol.150 , pp. 366-376
    • Wu, J.1
  • 18
    • 84900325394 scopus 로고    scopus 로고
    • A smooth muscle-like origin for beige adipocytes
    • Long J.Z., et al. A smooth muscle-like origin for beige adipocytes. Cell Metab. 2014, 19:810-820.
    • (2014) Cell Metab. , vol.19 , pp. 810-820
    • Long, J.Z.1
  • 19
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic N., et al. Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 2010, 285:7153-7164.
    • (2010) J. Biol. Chem. , vol.285 , pp. 7153-7164
    • Petrovic, N.1
  • 20
    • 0034085884 scopus 로고    scopus 로고
    • A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice
    • Fukui Y., et al. A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes 2000, 49:759-767.
    • (2000) Diabetes , vol.49 , pp. 759-767
    • Fukui, Y.1
  • 21
    • 0037312845 scopus 로고    scopus 로고
    • PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion
    • Laplante M., et al. PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. Diabetes 2003, 52:291-299.
    • (2003) Diabetes , vol.52 , pp. 291-299
    • Laplante, M.1
  • 22
    • 0037304599 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone
    • Wilson-Fritch L., et al. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol. Cell. Biol. 2003, 23:1085-1094.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1085-1094
    • Wilson-Fritch, L.1
  • 23
    • 85047689659 scopus 로고    scopus 로고
    • Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
    • Wilson-Fritch L., et al. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J. Clin. Invest. 2004, 114:1281-1289.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1281-1289
    • Wilson-Fritch, L.1
  • 24
    • 68849107400 scopus 로고    scopus 로고
    • C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists
    • Vernochet C., et al. C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists. Mol. Cell. Biol. 2009, 29:4714-4728.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 4714-4728
    • Vernochet, C.1
  • 25
    • 77954741222 scopus 로고    scopus 로고
    • Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells
    • Lepper C., Fan C.M. Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells. Genesis 2010, 48:424-436.
    • (2010) Genesis , vol.48 , pp. 424-436
    • Lepper, C.1    Fan, C.M.2
  • 26
    • 84903127498 scopus 로고    scopus 로고
    • Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed
    • Sanchez-Gurmaches J., Guertin D.A. Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed. Nat. Commun. 2014, 5:4099.
    • (2014) Nat. Commun. , vol.5 , pp. 4099
    • Sanchez-Gurmaches, J.1    Guertin, D.A.2
  • 27
    • 84897525104 scopus 로고    scopus 로고
    • Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice
    • Harms M.J., et al. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014, 19:593-604.
    • (2014) Cell Metab. , vol.19 , pp. 593-604
    • Harms, M.J.1
  • 28
    • 78650945931 scopus 로고    scopus 로고
    • Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
    • Seale P., et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J. Clin. Invest. 2011, 121:96-105.
    • (2011) J. Clin. Invest. , vol.121 , pp. 96-105
    • Seale, P.1
  • 29
    • 84892702771 scopus 로고    scopus 로고
    • Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
    • Cohen P., et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 2014, 156:304-316.
    • (2014) Cell , vol.156 , pp. 304-316
    • Cohen, P.1
  • 30
    • 79952155359 scopus 로고    scopus 로고
    • Transcriptional control of adipose lipid handling by IRF4
    • Eguchi J., et al. Transcriptional control of adipose lipid handling by IRF4. Cell Metab. 2011, 13:249-259.
    • (2011) Cell Metab. , vol.13 , pp. 249-259
    • Eguchi, J.1
  • 31
    • 0034783580 scopus 로고    scopus 로고
    • Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance
    • Guerra C., et al. Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. J. Clin. Invest. 2001, 108:1205-1213.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1205-1213
    • Guerra, C.1
  • 32
    • 79251528231 scopus 로고    scopus 로고
    • Tamoxifen-inducible Cre-mediated recombination in adipocytes
    • Sassmann A., et al. Tamoxifen-inducible Cre-mediated recombination in adipocytes. Genesis 2010, 48:618-625.
    • (2010) Genesis , vol.48 , pp. 618-625
    • Sassmann, A.1
  • 33
    • 77950081353 scopus 로고    scopus 로고
    • Transcriptional control of preadipocyte determination by Zfp423
    • Gupta R.K., et al. Transcriptional control of preadipocyte determination by Zfp423. Nature 2010, 464:619-623.
    • (2010) Nature , vol.464 , pp. 619-623
    • Gupta, R.K.1
  • 34
    • 84856970831 scopus 로고    scopus 로고
    • Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells
    • Gupta R.K., et al. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 2012, 15:230-239.
    • (2012) Cell Metab. , vol.15 , pp. 230-239
    • Gupta, R.K.1
  • 35
    • 53549130485 scopus 로고    scopus 로고
    • White fat progenitor cells reside in the adipose vasculature
    • Tang W., et al. White fat progenitor cells reside in the adipose vasculature. Science 2008, 322:583-586.
    • (2008) Science , vol.322 , pp. 583-586
    • Tang, W.1
  • 36
    • 77954506508 scopus 로고    scopus 로고
    • Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression
    • Wang Z.V., et al. Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology 2010, 151:2933-2939.
    • (2010) Endocrinology , vol.151 , pp. 2933-2939
    • Wang, Z.V.1
  • 37
    • 84887502374 scopus 로고    scopus 로고
    • Tracking adipogenesis during white adipose tissue development, expansion and regeneration
    • Wang Q.A., et al. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. 2013, 19:1338-1344.
    • (2013) Nat. Med. , vol.19 , pp. 1338-1344
    • Wang, Q.A.1
  • 38
    • 84897413090 scopus 로고    scopus 로고
    • Improved methodologies for the study of adipose biology: insights gained and opportunities ahead
    • Wang Q.A., et al. Improved methodologies for the study of adipose biology: insights gained and opportunities ahead. J. Lipid Res. 2014, 55:605-624.
    • (2014) J. Lipid Res. , vol.55 , pp. 605-624
    • Wang, Q.A.1
  • 39
    • 84859046711 scopus 로고    scopus 로고
    • Tamoxifen-induced Cre-loxP recombination is prolonged in pancreatic islets of adult mice
    • Reinert R.B., et al. Tamoxifen-induced Cre-loxP recombination is prolonged in pancreatic islets of adult mice. PLoS ONE 2012, 7:e33529.
    • (2012) PLoS ONE , vol.7 , pp. e33529
    • Reinert, R.B.1
  • 40
    • 84878525220 scopus 로고    scopus 로고
    • Bi-directional interconversion of brite and white adipocytes
    • Rosenwald M., et al. Bi-directional interconversion of brite and white adipocytes. Nat. Cell Biol. 2013, 15:659-667.
    • (2013) Nat. Cell Biol. , vol.15 , pp. 659-667
    • Rosenwald, M.1
  • 41
    • 84926486610 scopus 로고    scopus 로고
    • ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes
    • Ussar S., et al. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci. Transl. Med. 2014, 6:247ra103.
    • (2014) Sci. Transl. Med. , vol.6 , pp. 103-247
    • Ussar, S.1
  • 42
    • 53549134683 scopus 로고    scopus 로고
    • Identification of white adipocyte progenitor cells in vivo
    • Rodeheffer M.S., et al. Identification of white adipocyte progenitor cells in vivo. Cell 2008, 135:240-249.
    • (2008) Cell , vol.135 , pp. 240-249
    • Rodeheffer, M.S.1
  • 43
    • 75949096894 scopus 로고    scopus 로고
    • Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
    • Joe A.W., et al. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat. Cell Biol. 2010, 12:153-163.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 153-163
    • Joe, A.W.1
  • 44
    • 75949130333 scopus 로고    scopus 로고
    • Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle
    • Uezumi A., et al. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat. Cell Biol. 2010, 12:143-152.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 143-152
    • Uezumi, A.1
  • 45
    • 84859465056 scopus 로고    scopus 로고
    • In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding
    • Lee Y.H., et al. In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding. Cell Metab. 2012, 15:480-491.
    • (2012) Cell Metab. , vol.15 , pp. 480-491
    • Lee, Y.H.1
  • 46
    • 84875900015 scopus 로고    scopus 로고
    • EBF2 determines and maintains brown adipocyte identity
    • Rajakumari S., et al. EBF2 determines and maintains brown adipocyte identity. Cell Metab. 2013, 17:562-574.
    • (2013) Cell Metab. , vol.17 , pp. 562-574
    • Rajakumari, S.1
  • 47
    • 84907683854 scopus 로고    scopus 로고
    • Ebf2 is a selective marker of brown and beige adipogenic precursor cells
    • Wang W., et al. Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:14466-14471.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 14466-14471
    • Wang, W.1
  • 48
    • 77957220857 scopus 로고    scopus 로고
    • Comparative epigenomic analysis of murine and human adipogenesis
    • Mikkelsen T.S., et al. Comparative epigenomic analysis of murine and human adipogenesis. Cell 2010, 143:156-169.
    • (2010) Cell , vol.143 , pp. 156-169
    • Mikkelsen, T.S.1
  • 49
    • 64749111074 scopus 로고    scopus 로고
    • Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
    • Tateishi K., et al. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 2009, 458:757-761.
    • (2009) Nature , vol.458 , pp. 757-761
    • Tateishi, K.1
  • 50
    • 84889604511 scopus 로고    scopus 로고
    • EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
    • Ohno H., et al. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature 2013, 504:163-167.
    • (2013) Nature , vol.504 , pp. 163-167
    • Ohno, H.1
  • 51
    • 84900410413 scopus 로고    scopus 로고
    • Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
    • Kraus D., et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature 2014, 508:258-262.
    • (2014) Nature , vol.508 , pp. 258-262
    • Kraus, D.1
  • 52
    • 77956783846 scopus 로고    scopus 로고
    • Morphological and immunohistochemical features of brown adipocytes and preadipocytes in a case of human hibernoma
    • Manieri M., et al. Morphological and immunohistochemical features of brown adipocytes and preadipocytes in a case of human hibernoma. Nutr. Metab. Cardiovasc. Dis. 2010, 20:567-574.
    • (2010) Nutr. Metab. Cardiovasc. Dis. , vol.20 , pp. 567-574
    • Manieri, M.1
  • 53
    • 70349334680 scopus 로고    scopus 로고
    • The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    • Zingaretti M.C., et al. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 2009, 23:3113-3120.
    • (2009) FASEB J. , vol.23 , pp. 3113-3120
    • Zingaretti, M.C.1
  • 54
    • 84875858745 scopus 로고    scopus 로고
    • White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma
    • Frontini A., et al. White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma. Biochim. Biophys. Acta 2013, 1831:950-959.
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 950-959
    • Frontini, A.1
  • 55
    • 84869233588 scopus 로고    scopus 로고
    • Human BAT possesses molecular signatures that resemble beige/brite cells
    • Sharp L.Z., et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS ONE 2012, 7:e49452.
    • (2012) PLoS ONE , vol.7 , pp. e49452
    • Sharp, L.Z.1
  • 56
    • 84877340732 scopus 로고    scopus 로고
    • Evidence for two types of brown adipose tissue in humans
    • Lidell M.E., et al. Evidence for two types of brown adipose tissue in humans. Nat. Med. 2013, 19:631-634.
    • (2013) Nat. Med. , vol.19 , pp. 631-634
    • Lidell, M.E.1
  • 57
    • 84877331455 scopus 로고    scopus 로고
    • Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    • Cypess A.M., et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat. Med. 2013, 19:635-639.
    • (2013) Nat. Med. , vol.19 , pp. 635-639
    • Cypess, A.M.1
  • 58
    • 84877263632 scopus 로고    scopus 로고
    • A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans
    • Jespersen N.Z., et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab. 2013, 17:798-805.
    • (2013) Cell Metab. , vol.17 , pp. 798-805
    • Jespersen, N.Z.1
  • 59
    • 84936771989 scopus 로고    scopus 로고
    • Genetic and functional characterization of clonally-derived adult human brown adipocytes
    • Published online March 16, 2015
    • Shinoda K., et al. Genetic and functional characterization of clonally-derived adult human brown adipocytes. Nat. Med. 2015, Published online March 16, 2015. 10.1038/nm.3819.
    • (2015) Nat. Med.
    • Shinoda, K.1
  • 60
    • 67650242165 scopus 로고    scopus 로고
    • High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity
    • Saito M., et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009, 58:1526-1531.
    • (2009) Diabetes , vol.58 , pp. 1526-1531
    • Saito, M.1
  • 62
    • 84881260642 scopus 로고    scopus 로고
    • Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
    • van der Lans A.A., et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J. Clin. Invest. 2013, 123:3395-3403.
    • (2013) J. Clin. Invest. , vol.123 , pp. 3395-3403
    • van der Lans, A.A.1
  • 63
    • 77950221998 scopus 로고    scopus 로고
    • Human brown adipose tissue
    • Enerback S. Human brown adipose tissue. Cell Metab. 2010, 11:248-252.
    • (2010) Cell Metab. , vol.11 , pp. 248-252
    • Enerback, S.1
  • 64
    • 0022536596 scopus 로고
    • Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo
    • Ma S.W., Foster D.O. Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo. Can. J. Physiol. Pharmacol. 1986, 64:609-614.
    • (1986) Can. J. Physiol. Pharmacol. , vol.64 , pp. 609-614
    • Ma, S.W.1    Foster, D.O.2
  • 65
    • 84911896533 scopus 로고    scopus 로고
    • Brown adipose tissue improves whole body glucose homeostasis and insulin sensitivity in humans
    • Chondronikola M., et al. Brown adipose tissue improves whole body glucose homeostasis and insulin sensitivity in humans. Diabetes 2014, 63:4089-4099.
    • (2014) Diabetes , vol.63 , pp. 4089-4099
    • Chondronikola, M.1
  • 66
    • 84907973405 scopus 로고    scopus 로고
    • Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans
    • Lee P., et al. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans. Diabetes 2014, 63:3686-3698.
    • (2014) Diabetes , vol.63 , pp. 3686-3698
    • Lee, P.1
  • 67
    • 84881221754 scopus 로고    scopus 로고
    • Recruited brown adipose tissue as an antiobesity agent in humans
    • Yoneshiro T., et al. Recruited brown adipose tissue as an antiobesity agent in humans. J. Clin. Invest. 2013, 123:3404-3408.
    • (2013) J. Clin. Invest. , vol.123 , pp. 3404-3408
    • Yoneshiro, T.1
  • 68
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: mechanisms of differentiation and function
    • Josefowicz S.Z., et al. Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 2012, 30:531-564.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1
  • 69
    • 36249024247 scopus 로고    scopus 로고
    • Regulatory T cells - a brief history and perspective
    • Sakaguchi S., et al. Regulatory T cells - a brief history and perspective. Eur. J. Immunol. 2007, 37(Suppl. 1):S116-S123.
    • (2007) Eur. J. Immunol. , vol.37 , pp. S116-S123
    • Sakaguchi, S.1
  • 70
    • 79953748708 scopus 로고    scopus 로고
    • TLE3 is a dual-function transcriptional coregulator of adipogenesis
    • Villanueva C.J., et al. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 2011, 13:413-427.
    • (2011) Cell Metab. , vol.13 , pp. 413-427
    • Villanueva, C.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.