The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Chowdhury, Basudev ^a,b   McGovern, Andrew ^c,d   Cui, Yi ^b,e   Choudhury, Samrat Roy ^b,e   Cho, Il Hoon ^b,e   Cooper, Bruce ^b   Chevassut, Timothy ^d   Lossie, Amy C ^b   Irudayaraj, Joseph ^b,e  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

^e Purdue University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; 5-CARBOXYLCYTOSINE; 5-FORMYLCYTOSINE; 5-HYDROXYMETHYLCYTOSINE; AZACITIDINE; CYTOSINE; DECITABINE; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA BINDING PROTEIN; MIXED FUNCTION OXIDASE; ONCOPROTEIN; PROTEIN BINDING; TET1 PROTEIN, HUMAN;

ACUTE MYELOID LEUKEMIA; ANALOGS AND DERIVATIVES; CHEMISTRY; CPG ISLAND; DNA METHYLATION; ENZYME ACTIVE SITE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HL-60 CELL LINE; HUMAN; IMMUNOHISTOCHEMISTRY; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; SPECTROFLUOROMETRY; TANDEM MASS SPECTROMETRY;

5-METHYLCYTOSINE; AZACITIDINE; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CPG ISLANDS; CYTOSINE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HL-60 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKEMIA, MYELOID, ACUTE; MCF-7 CELLS; MICROSCOPY, FLUORESCENCE; MIXED FUNCTION OXYGENASES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; SPECTROMETRY, FLUORESCENCE; TANDEM MASS SPECTROMETRY;

EID: 84928723198     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09281     Document Type: Article

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