NFATc1 links EGFR signaling to induction of sox9 transcription and acinar-ductal transdifferentiation in the pancreas

Gastroenterology

Volumn 148, Issue 5, 2015, Pages 1024-1034.e9

  Chen, Nai Ming ^a   Singh, Garima ^b   Koenig, Alexander ^a,c   Liou, Geou Yarh ^d   Storz, Peter ^d   Zhang, Jin San ^c,e   Regul, Lisanne ^b   Nagarajan, Sankari ^a   Kühnemuth, Benjamin ^b   Johnsen, Steven A ^a   Hebrok, Matthias ^f   Siveke, Jens ^g   Billadeau, Daniel D ^c   Ellenrieder, Volker ^a   Hessmann, Elisabeth ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c MAYO CLINIC   (United States)

^d MAYO CLINIC   (United States)

^e WENZHOU MEDICAL UNIVERSITY   (China)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

ChIP; Gene Regulation; Mouse Model; Signal Transduction

Indexed keywords

CYTOKERATIN 19; CYTOKERATIN 7; EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN C JUN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT C1; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG; UVOMORULIN; CERULETIDE; CYCLOSPORIN; EGFR PROTEIN, HUMAN; EGFR PROTEIN, MOUSE; KRAS2 PROTEIN, MOUSE; NFATC1 PROTEIN, HUMAN; NFATC1 PROTEIN, MOUSE; PROTEIN P21; SOX9 PROTEIN, HUMAN; SOX9 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARCINOGENESIS; CELL TRANSDIFFERENTIATION; CHROMATIN; CHRONIC PANCREATITIS; COMPLEX FORMATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE CONTROL; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; METAPLASIA; MOUSE; NONHUMAN; ONCOGENE C FOS; PANCREAS CANCER; PANCREAS INJURY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; ANIMAL; C57BL MOUSE; CELL LINE; CELL TRANSFORMATION; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; MUTATION; PANCREAS; PANCREAS CARCINOMA; PANCREAS DUCT; PANCREAS TUMOR; PANCREATITIS; PATHOLOGY; PRECANCER; TISSUE CULTURE TECHNIQUE;

ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE; CELL TRANSDIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; CERULETIDE; CYCLOSPORINE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; MALE; METAPLASIA; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; NFATC TRANSCRIPTION FACTORS; PANCREAS, EXOCRINE; PANCREATIC DUCTS; PANCREATIC NEOPLASMS; PANCREATITIS; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SOX9 TRANSCRIPTION FACTOR; TISSUE CULTURE TECHNIQUES; TRANSCRIPTIONAL ACTIVATION;

EID: 84928604113     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.01.033     Document Type: Article

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