Identification of selective inhibitors of the Plasmodium falciparum hexose transporter PfHT by screening focused libraries of anti-malarial compounds

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Ortiz, Diana ^a   Guiguemde, W Armand ^b   Johnson, Alex ^a,c   Elya, Carolyn ^a,d   Anderson, Johanna ^a   Clark, Julie ^b   Connelly, Michele ^b   Yang, Lei ^b   Min, Jaeki ^b   Sato, Yuko ^a,e   Guy, R Kiplin ^b   Landfear, Scott M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; GAMBOGIC ACID; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 1; HEXOSE TRANSPORTER INHIBITOR; MEFLOQUINE; UNCLASSIFIED DRUG; GLUCOSE; PROTOZOAL PROTEIN;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; FEMALE; FIBROBLAST; GROWTH INHIBITION; HETEROLOGOUS EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; INHIBITION KINETICS; LEISHMANIA MEXICANA; LIVER MICROSOME; MALE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PREPUCE; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; ERYTHROCYTE; KINETICS; METABOLISM; PARASITE; PARASITOLOGY; PROCEDURES;

LEISHMANIA MEXICANA; MAMMALIA; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; CELL PROLIFERATION; ERYTHROCYTES; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KINETICS; MALE; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; PARASITES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 84928494356     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123598     Document Type: Article

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