Enhanced therapeutic siRNA to tumor cells by a pH-sensitive agmatine-chitosan bioconjugate

ACS Applied Materials and Interfaces

Volumn 7, Issue 15, 2015, Pages 8114-8124

  Li, Yongmao ^a,b   Yang, Jianhai ^a   Xu, Bing ^a   Gao, Fei ^a   Wang, Wei ^a,c   Liu, Wenguang ^a,b  

^a TIANJIN UNIVERSITY   (China)

^b SynBio Research Platform   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

agmatine; cancer therapy; charge conversion; chitosan; gene silencing

Indexed keywords

BIOMOLECULES; BODY FLUIDS; CHITIN; CHITOSAN; DISEASES; GENES; GENETIC ENGINEERING; ONCOLOGY; TUMORS;

AGMATINE; BIOCONJUGATES; CANCER THERAPY; GENE SILENCING; NANOCOMPLEXES; NATURALLY OCCURRING; NUCLEOPHILIC REACTION; PRIMARY AMINES;

GENE THERAPY;

DELAYED RELEASE FORMULATION; NANOCAPSULE; NANOCONJUGATE; SMALL INTERFERING RNA; VASCULOTROPIN A;

ADMINISTRATION AND DOSAGE; ANIMAL; BAGG ALBINO MOUSE; CELL SURVIVAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG EFFECTS; GENE THERAPY; GENETICS; HELA CELL LINE; HUMAN; MATERIALS TESTING; MOUSE; PH; PROCEDURES; ULTRASTRUCTURE;

ANIMALS; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; GENETIC THERAPY; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MATERIALS TESTING; MICE; MICE, INBRED BALB C; NANOCAPSULES; NANOCONJUGATES; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84928474123     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b00851     Document Type: Article

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