Diet-based strategies for cancer chemoprevention: The role of combination regimens using dietary bioactive components

Annual Review of Food Science and Technology

Volumn 6, Issue , 2015, Pages 505-526

  Dimarco Crook, Christina ^a   Xiao, Hang ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Breast cancer; Cancer chemoprevention; Colorectal cancer; Combination; Dietary bioactive components; Lung cancer; Prostate cancer; Synergy; Whole foods

Indexed keywords

PLANNING;

BIOACTIVE COMPONENTS; BREAST CANCER; CANCER CHEMOPREVENTION; COLORECTAL CANCER; COMBINATION; LUNG CANCER; PROSTATE CANCERS; SYNERGY;

DISEASES;

CHEMOPROPHYLAXIS; CLASSIFICATION; DIET THERAPY; FEMALE; HUMAN; MALE; NEOPLASMS;

CHEMOPREVENTION; FEMALE; HUMANS; MALE; NEOPLASMS;

EID: 84928472282     PISSN: 19411413     EISSN: 19411421     Source Type: Journal    
DOI: 10.1146/annurev-food-081114-110833     Document Type: Review

References (117)

1. Altenburg JD, Bieberich AA, Terry C, Harvey KA, VanHorn JF, et al. 2011. A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone. BMC Cancer 11:149
2. Amin AR, Wang D, Zhang H, Peng S, Shin HJ, et al. 2010. Enhanced anti-tumor activity by the combination of the natural compounds -epigallocatechin-3-gallate and luteolin: potential role of p53. J. Biol. Chem. 285(45):34557-65
3. Awad AB, Burr AT, Fink CS. 2005. Effect of resveratrol and beta-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells. Prostaglandins Leukot. Essent. Fatty Acids 72(3):219-26
4. Barrera LN, Johnson IT, Bao Y, Cassidy A, Belshaw NH. 2013. Colorectal cancer cells Caco-2 and HCT116
5. resist epigenetic effects of isothiocyanates and selenium in vitro. Eur. J. Nutr. 52(4):1327-41
6. Basu A, Imrhan V. 2007. Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials. Eur. J. Clin. Nutr. 61(3):295-303
7. Bird RP. 1995. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett. 93(1):55-71
8. Bonnesen C, Eggleston IM, Hayes JD. 2001. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection againstDNAdamage in human colon cell lines. Cancer Res. 61(16):6120-30
9. Bose M, Hao X, Husain A, Park S, Lambert JD, Yang. 2007. Inhibition of tumorigenesis in ApcMin/+ mice by a combination of epigallocatechin-3-gallate and fish oil. J. Agric. Food Chem. 55(19):7695-700
10. Boursi B, Arber N. 2007. Current and future clinical strategies in colon cancer prevention and the emerging role of chemoprevention. Curr. Pharm. Des. 13(22):2274-82
11. Brahmbhatt M, Gundala SR, Asif G, Shamsi SA, Aneja R. 2013. Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation. Nutr. Cancer 65(2):263-72
12. Butler LM,Wu AH, Wang R, Koh WP, Yuan JM, YuMC. 2010. A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal SingaporeChinese women. Am. J. Clin. Nutr. 91(4):1013-19
13. Canene-Adams K, Lindshield BL, Wang S, Jeffery EH, Clinton SK, Erdman JW Jr. 2007. Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas. Cancer Res. 67(2):836-43
14. Challa A, Rao DR, Reddy BS. 1997. Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea. Carcinogenesis 18(10):2023-26
15. Chen C, Kong AN. 2005. Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol. Sci. 26(6):318-26
16. ChengAL, HsuCH, Lin JK, HsuMM,HoYF, et al. 2001. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21(4B):2895-900
17. Chou TC. 2006. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol. Rev. 58(3):621-81
18. Chou TC, Talalay P. 1984. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul. 22:27-55
19. Constantinou AI, White BE, Tonetti D, Yang Y, LiangW, et al. 2005. The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours. Eur. J. Cancer 41(4):647-54
20. Crim KC, Sanders LM, Hong MW, Taddeo SS, Turner ND, et al. 2008. Upregulation of p21Waf1/Cip1
21. expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the diet. Carcinogenesis 29(7):1415-20
22. Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, et al. 2006. Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin. Gastroenterol. Hepatol. 4(8):1035-38
23. Dagne A, Melkamu T, Schutten MM, Qian X, Upadhyaya P, et al. 2011. Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice. Carcinogenesis 32(4):561-67
24. Davis CD, Emenaker NJ, Milner JA. 2010. Cellular proliferation, apoptosis and angiogenesis: molecular targets for nutritional preemption of cancer. Semin. Oncol. 37(3):243-57
25. Dong X, Xu W, Sikes RA, Wu C. 2013. Combination of low dose of genistein and daidzein has synergistic preventive effects on isogenic human prostate cancer cells when compared with individual soy isoflavone. Food Chem. 141(3):1923-33
26. Fan S, Meng Q, Auborn K, Carter T, Rosen EM. 2006. BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br. J. Cancer 94(3):407-26
27. Fresco P, Borges F, Diniz C, Marques MP. 2006. New insights on the anticancer properties of dietary polyphenols. Med. Res. Rev. 26(6):747-66
28. Garcea G, Berry DP, Jones DJ, Singh R, Dennison AR, et al. 2005. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol. Biomark. Prev. 14(1):120-25
29. George J, Singh M, Srivastava AK, Bhui K, Roy P, et al. 2011a. Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53. PLOS ONE 6(8):e23395
30. George J, Singh M, Srivastava AK, Bhui K, Shukla Y. 2011b. Synergistic growth inhibition of mouse skin tumors by pomegranate fruit extract and diallyl sulfide: evidence for inhibition of activated MAPKs/NFB and reduced cell proliferation. Food Chem. Toxicol. 49(7):1511-20
31. Greco WR, Bravo G, Parsons JC. 1995. The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev. 47(2):331-85
32. Greenwald P. 2002. Cancer chemoprevention. BMJ 324(7339):714-18
33. Gunasekera RS, Sewgobind K, Desai S, Dunn L, Black HS, McKeehan WL, Patil B. 2007. Lycopene and lutein inhibit proliferation in rat prostate carcinoma cells. Nutr. Cancer 58(2):171-77
34. Harper CE, Cook LM, Patel BB, Wang J, Eltoum IA, et al. 2009. Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats. Prostate 69(15):1668-82
35. Horie N, Hirabayashi N, Takahashi Y, Miyauchi Y, Taguchi H, Takeishi K. 2005. Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells. Biol. Pharm. Bull. 28(4):574-79
36. Hsieh TC, Wu JM. 2008. Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and gamma-tocotrienol in estrogen receptor-positiveMCF-7 breast cancer cells. Int. J. Oncol. 33(4):851-59
37. Hsieh TC, Wu JM. 2009. Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin. Anticancer Res. 29(10):4025-32
38. Hsu A, Bray TM, Helferich WG, Doerge DR, Ho E. 2010. Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. Exp. Biol. Med. (Maywood) 235(1):90-97
39. Hsu A, Bruno RS, Löhr CV, Taylor AW, Dashwood RH, et al. 2011. Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFB pathway in theNoble rat model. J. Nutr. Biochem. 22(5):502-10
40. Hsu EL, Chen N, Westbrook A, Wang F, Zhang R, et al. 2009. Modulation of CXCR4, CXCL12, and tumor cell invasion potential in vitro by phytochemicals. J. Oncol. 2009:491985
41. Hu Y, McIntosh GH, Le Leu RK, Nyskohus LS, Woodman RJ, et al. 2013. Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancermodel bymodulating genetic and epigenetic biomarkers. PLOS ONE 8(5):e64362
42. Hutzen B, Willis W, Jones S, Chen L, Deangelis S, et al. 2009. Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells. Cancer Cell Int. 9:24-27
43. Ip C, Ganther HE. 1991. Combination of blocking agents and suppressing agents in cancer prevention. Carcinogenesis 12(2):365-67
44. Iwuchukwu OF, Tallarida RJ, Nagar S. 2011. Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells. Life Sci. 88(23-24):1047-54
45. Jemal A, Siegal R, Xu J,Ward E. 2010. Cancer statistics, 2010. CA Cancer J. Clin. 60:277-300
46. JeuneMA, Kumi-Diaka J, Brown J. 2005. Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. J. Med. Food 8(4):469-75
47. Jiang H, Shang X, Wu H, Huang G, Wang Y, et al. 2010. Combination treatment with resveratrol and sulforaphane induces apoptosis in human U251 glioma cells. Neurochem. Res. 35(1):152-61
48. Khafif A, Schantz SP, Chou TC, Edelstein D, Sacks PG. 1998. Quantitation of chemopreventive synergism between -epigallocatechin-3-gallate and curcumin in normal, premalignant andmalignant human oral epithelial cells. Carcinogenesis 19(3):419-24
49. Klein EA, Thompson IM, Tangen CM, Crowley JJ, Lucia MS, et al. 2011. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 306(14):1549-56
50. Kolar SS, Barhoumi R, Callaway ES, Fan Y-Y, Wang N, et al. 2007. Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis viamitochondrial Ca2+ accumulation in colonocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 293(5):G935-943
51. Kramer F, Johnson IT, Doleman JF, Lund EK. 2009. A comparison of the effects of soya isoflavonoids and fish oil on cell proliferation, apoptosis and the expression of oestrogen receptors alpha and beta in the mammary gland and colon of the rat. Br. J. Nutr. 102(1):29-36
52. Kronbak R, Duus F, Vang O. 2010. Effect of 4-methoxyindole-3-carbinol on the proliferation of colon cancer cells in vitro, when treated alone or in combination with indole-3-carbinol. J. Agric. Food Chem. 58(14):8453-59
53. Kumar R, Verma V, Jain A, Jain RK, Maikhuri JP, Gupta G. 2011. Synergistic chemoprotective mechanisms of dietary phytoestrogens in a select combination against prostate cancer. J. Nutr. Biochem. 22(8):723-31
54. Kumi-Diaka J,MerchantK,Haces A,Hormann V, JohnsonM2010. Genistein-selenium combination induces growth arrest in prostate cancer cells. J. Med. Food 13(4):842-50
55. Lansky EP, JiangW, Mo H, Bravo L, Froom P, et al. 2005. Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions. Investig. New Drugs 23(1):11-20
56. Lee JJ, Kong M, Ayers GD, Lotan R. 2007. Interaction index and different methods for determining drug interaction in combination therapy. J. Biopharm. Stat. 17(3):461-80
57. Legg RL, Tolman JR, Lovinger CT, Lephart ED, Setchell K, Christensen MJ. 2008. Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate. Reprod. Biol. Endocrinol. 6:57
58. Li W, Wu JX, Tu YY. 2010. Synergistic effects of tea polyphenols and ascorbic acid on human lung adenocarcinoma SPC-A-1 cells. J. Zhejiang Univ. Sci. B 11(6):458-64
59. Lindshield BL, Ford NA, Canene-Adams K, Diamond AM, Wallig MA, Erdman JW. 2010. Selenium, but not lycopene or vitamin E, decreases growth of transplantable dunning R3327-H rat prostate tumors. PLOS ONE 5(4):e10423
60. Lund E. 2003. Non-nutritive bioactive constituents of plants: dietary sources and health benefits of glucosinolates. Int. J. Vitam. Nutr. Res. 73(2):135-43
61. Majumdar AP, Banerjee S, Nautiyal J, Patel V, Du J, et al. 2009. Curcumin synergizes with resveratrol to inhibit colon cancer. Nutr. Cancer 61(4):544-53
62. Martin KR. 2006. Targeting apoptosis with dietary bioactive agents. Exp. Biol. Med. (Maywood) 231(2):117-29
63. Martinez-Montemayor MM, Otero-Franqui E, Martinez J, De La Mota-Peynado A, Cubano LA, Dharmawardhane S. 2010. Individual and combined soy isoflavones exert differential effects onmetastatic cancer progression. Clin. Exp. Metastasis 27(7):465-80
64. McGrath DR, Spigelman AD. 2008. Putative mechanisms of action for indole-3-carbinol in the prevention of colorectal cancer. Expert Opin. Ther. Targets 12(6):729-38
65. Mertens-Talcott SU, Percival SS. 2005. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lett. 218(2):141-51
66. Nakagawa H, Yamamoto D, Kiyozuka Y, Tsuta K, Uemura Y, et al. 2000. Effects of genistein and synergistic action in combination with eicosapentaenoic acid on the growth of breast cancer cell lines. J. Cancer Res. Clin. Oncol. 126(8):448-54
67. Nakamura Y, Yogosawa S, Izutani Y, Watanabe H, Otsuji E, Sakai T. 2009. A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol. Cancer 8:100
68. Neergheen VS, Bahorun T, Taylor EW, Jen LS, Aruoma OI. 2010. Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention. Toxicology 278(2):229-41
69. Nho CW, Jeffery E. 2004. Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol. Toxicol. Appl. Pharmacol. 198(1):40-48
70. Osaki M, OshimuraM, Ito H. 2004. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9(6):667-76
71. Pappa G, Strathmann J, Lowinger M, Bartsch H, Gerhauser C. 2007. Quantitative combination effects between sulforaphane and 3,3-diindolylmethane on proliferation of human colon cancer cells in vitro. Carcinogenesis 28(7):1471-77
72. Pesakhov S, Khanin M, StudzinskiGP, DanilenkoM. 2010. Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells. Nutr. Cancer 62(6):811-24
73. Powell SM, Zilz N, Beazer-Barclay Y, BryanTM, Hamilton SR, et al. 1992. APCmutations occur early during colorectal tumorigenesis. Nature 359(6392):235-37
74. Power KA, Chen JM, Saarinen NM, Thompson LU. 2008. Changes in biomarkers of estrogen receptor and growth factor signaling pathways in MCF-7 tumors after short-and long-term treatment with soy and flaxseed. J. Steroid Biochem. Mol. Biol. 112(1-3):13-19
75. Power KA, Thompson LU. 2007. Can the combination of flaxseed and its lignans with soy and its isoflavones reduce the growth stimulatory effect of soy and its isoflavones on established breast cancer? Mol. Nutr. Food Res. 51(7):845-56
76. Pradhan SJ, Mishra R, Sharma P, Kundu GC. 2010. Quercetin and sulforaphane in combination suppress the progression of melanoma through the down-regulation of matrix metalloproteinase-9. Exp. Ther. Med. 1(6):915-20
77. Radhakrishnan S, Reddivari L, Sciafani R, Das UN, Vanamala J. 2011. Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. Front. Biosci. (Elite Ed.) 3:1509-23
78. Raj MH, Abd Elmageed ZY, Zhou J, Gaur RL, Nguyen L, et al. 2008. Synergistic action of dietary phytoantioxidants on survival and proliferation of ovarian cancer cells. Gynecol. Oncol. 110(3):432-38
79. Ramos S. 2008. Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol. Nutr. Food Res. 52(5):507-26
80. Rao CV, Reddy BS. 2004. NSAIDs and chemoprevention. Curr. Cancer Drug Targets 4(1):29-42
81. Reagan-Shaw S, Nihal M, Ahsan H, Mukhtar H, Ahmad N. 2008. Combination of vitamin E and selenium causes an induction of apoptosis of human prostate cancer cells by enhancing Bax/Bcl-2 ratio. Prostate 68(15):1624-34
82. RoyMJ, Dionne S, Marx G, Qureshi I, Sarma D, et al. 2009. In vitro studies on the inhibition of colon cancer by butyrate and carnitine. Nutrition 25(11-12):1193-201
83. Saarinen NM, Power K, Chen J, Thompson LU. 2006. Flaxseed attenuates the tumor growth stimulating effect of soy protein in ovariectomized athymic mice with MCF-7 human breast cancer xenografts. Int. J. Cancer 119(4):925-31
84. Saha A, Kuzuhara T, Echigo N, Suganuma M, Fujiki H. 2010. New role of -epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin. Cancer Prev. Res. (Phila.) 3(8):953-62
85. Sakamoto K. 2000. Synergistic effects of thearubigin and genistein on human prostate tumor cell (PC-3) growth via cell cycle arrest. Cancer Lett. 151(1):103-9
86. Saw CL, Cintron M, Wu TY, Guo Y, Huang Y, et al. 2011. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm. Drug Dispos. 32(5):289-300
87. Schwartz B, Birk Y, Raz A, Madar Z. 2004. Nutritional-pharmacological combinations-a novel approach to reducing colon cancer incidence. Eur. J. Nutr. 43(4):221-29
88. Seeram NP, Adams LS, Hardy ML, Heber D. 2004. Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J. Agric. Food Chem. 52(9):2512-17
89. Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, et al. 2005. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J. Nutr. Biochem. 16(6):360-67
90. Sengupta A, Ghosh S, Das S. 2003. Tomato and garlic can modulate azoxymethane-induced colon carcinogenesis in rats. Eur. J. Cancer Prev. 12(3):195-200
91. Sengupta A, Ghosh S, Das S. 2004. Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane induced colon carcinogenesis in rat. Cancer Lett. 208(2):127-36
92. ShenG,KhorTO,HuR, Yu S, Nair S, et al. 2007. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in Apc Min/+mouse. Cancer Res. 67(20):9937-44
93. Siler U, Barella L, Spitzer V, Schnow Lein M, et al. 2004. Lycopene and vitamin E interfere with autocrine/ paracrine loops in the Dunning prostate cancer model. FASEB J. 18(9):1019-21
94. SvehlikováV,Wang S, Jakubikova J, WilliamsonG,MithenR, Bao Y. 2004. Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells. Carcinogenesis 25(9):1629-37
95. Tanaka T, Makita H, Kawabata K, Mori H, Kakumoto M, et al. 1997. Chemoprevention of azoxymethaneinduced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin. Carcinogenesis 18(5):957-65
96. Tang FY, Cho HJ, Pai MH, Chen YH. 2009. Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells. J. Nutr. Biochem. 20(6):426-34
97. Tang SN, Singh C, Nall D, Meeker D, Shankar S, Srivastava RK. 2010. The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J. Mol. Signal. 5:14
98. Tolman JR, Lephart ED, Setchell KD, Eggett DL, Christensen MJ. 2008. Timing of supplementation of selenium and isoflavones determines prostate cancer risk factor reduction in rats. Nutr. Metab. (Lond.) 5:31
99. Tsuda H, Ohshima Y,NomotoH, FujitaKI, Matsuda E, et al. 2004. Cancer prevention by natural compounds. Drug Metab. Pharmacokinet. 19(4):245-63
100. Vaishampayan U, Hussain M, Banerjee M, Seren S, Sarkar FH, et al. 2007. Lycopene and soy isoflavones in the treatment of prostate cancer. Nutr. Cancer 59(1):1-7
101. Velmurugan B, Mani A, Nagini S. 2005. Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis. Eur. J. Cancer Prev. 14(4):387-93
102. Venkateswaran V, Fleshner NE, Klotz LH. 2004. Synergistic effect of vitamin E and selenium in human prostate cancer cell lines. Prostate Cancer Prostatic Dis. 7(1):54-56
103. Venkateswaran V, Klotz LH, Ramani M, Sugar LM, Jacob LE, et al. 2009. A combination of micronutrients is beneficial in reducing the incidence of prostate cancer and increasing survival in the Lady transgenic model. Cancer Prev. Res. (Phila.) 2(5):473-83
104. Verma SP, Salamone E, Goldin B. 1997. Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. Biochem. Biophys. Res. Commun. 233(3):692-96
105. Vicinanza R, Zhang Y,Henning SM,Heber D. 2013. Pomegranate juice metabolites, ellagic acid and urolithin A, synergistically inhibit androgen-independent prostate cancer cell growth via distinct effects on cell cycle control and apoptosis. Evid. Based Complement. Altern. Med. 2013:247504
106. Vieira A, Heidor R, Cardozo MT, Scolastici C, Purgatto E, et al. 2011. Efficacy of geraniol but not of betaionone or their combination for the chemoprevention of rat colon carcinogenesis. Braz. J. Med. Biol Res. 44(6):538-45
107. Wang P, Heber D, Henning SM. 2012. Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo. Food Funct. 3(6):635-42
108. Wang Z, Desmoulin S, Banerjee S, Kong D, Li Y, et al. 2008. Synergistic effects of multiple natural products in pancreatic cancer cells. Life Sci. 83(7-8):293-300
109. Willard ST, FrawleyLS. 1998. Phytoestrogens have agonistic and combinatorial effects on estrogen-responsive gene expression in MCF-7 human breast cancer cells. Endocrine 8(2):117-21
110. Xiao H, Yang CS. 2008. Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention. Int. J. Cancer 123(5):983-90
111. Xu G, Ren G, Yuan H, Wang Z, Kang L, et al. 2010. Combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis. Food Chem. Toxicol. 48(1):390-95
112. Yang J, Liu RH. 2009. Synergistic effect of apple extracts and quercetin 3-D-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells in vitro. J. Agric. Food Chem. 57(18):8581-86
113. Yi W, Wetzstein HY. 2011. Anti-tumorigenic activity of five culinary and medicinal herbs grown under greenhouse conditions and their combination effects. J. Sci. Food Agric. 91(10):1849-54
114. Zhou JR, Li L, Pan W. 2007. Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting metabolic syndrome elements in mice. Am. J. Clin. Nutr. 86(3):s882-88
115. Zhou JR, Yu L, Mai Z, Blackburn GL. 2004. Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice. Int. J. Cancer 108(1):8-14
116. Zhou JR, Yu L, Zhong Y, Blackburn GL. 2003. Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice. J. Nutr. 133(2):516-21
117. Zuniga KE, Clinton SK, Erdman JW. 2013. The interactions of dietary tomato powder and soy germ on prostate carcinogenesis in the TRAMP model. Cancer Prev. Res. (Phila.) 6(6):548-57