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Volumn 6, Issue 10, 2015, Pages 7504-7521

TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis

Author keywords

Angiogenesis; Mouse model; Pancreatic cancer; STAT3; TGF

Indexed keywords

HISTONE DEACETYLASE 9; JANUS KINASE 1; JANUS KINASE 2; RUXOLITINIB; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; VASCULAR ENDOTHELIAL CADHERIN;

EID: 84928396303     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3233     Document Type: Article
Times cited : (41)

References (75)
  • 2
    • 33745348878 scopus 로고    scopus 로고
    • Cytotoxic chemotherapy for pancreatic cancer: Advances to date and future directions
    • Xiong HQ, Carr K, Abbruzzese JL. Cytotoxic chemotherapy for pancreatic cancer: Advances to date and future directions. Drugs. 2006; 66:1059-1072.
    • (2006) Drugs , vol.66 , pp. 1059-1072
    • Xiong, H.Q.1    Carr, K.2    Abbruzzese, J.L.3
  • 3
    • 0037208652 scopus 로고    scopus 로고
    • Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients
    • Lim JE, Chien MW, Earle CC. Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients. Annals of surgery. 2003; 237:74-85.
    • (2003) Annals of surgery , vol.237 , pp. 74-85
    • Lim, J.E.1    Chien, M.W.2    Earle, C.C.3
  • 4
    • 0034094977 scopus 로고    scopus 로고
    • Molecular genetic alterations in ductal pancreatic adenocarcinomas
    • Kern SE. Molecular genetic alterations in ductal pancreatic adenocarcinomas. The Medical clinics of North America. 2000; 84:691-695xi.
    • (2000) The Medical clinics of North America , vol.84 , pp. 691-695+xi
    • Kern, S.E.1
  • 5
    • 34648852355 scopus 로고    scopus 로고
    • Pancreatic cancer-associated stroma production
    • Korc M. Pancreatic cancer-associated stroma production. American journal of surgery. 2007; 194:S84-86.
    • (2007) American journal of surgery , vol.194 , pp. S84-S86
    • Korc, M.1
  • 6
    • 0030754056 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression
    • Itakura J, Ishiwata T, Friess H, Fujii H, Matsumoto Y, Büchler MW, Korc M. Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clinical Cancer Research. 1997; 3:1309-1316.
    • (1997) Clinical Cancer Research , vol.3 , pp. 1309-1316
    • Itakura, J.1    Ishiwata, T.2    Friess, H.3    Fujii, H.4    Matsumoto, Y.5    Büchler, M.W.6    Korc, M.7
  • 7
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y, Baba H, Fukuda T, Takashima M, Sugimachi K. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer. 2000; 88:2239-2245.
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3    Takashima, M.4    Sugimachi, K.5
  • 10
    • 0035342593 scopus 로고    scopus 로고
    • Pancreatic cancer cell-derived vascular endothelial growth factor is biologically active in vitro and enhances tumorigenicity in vivo
    • Luo J, Guo P, Matsuda K, Truong N, Lee A, Chun C, Cheng S-Y, Korc M. Pancreatic cancer cell-derived vascular endothelial growth factor is biologically active in vitro and enhances tumorigenicity in vivo. International Journal of Cancer. 2001; 92:361-369.
    • (2001) International Journal of Cancer , vol.92 , pp. 361-369
    • Luo, J.1    Guo, P.2    Matsuda, K.3    Truong, N.4    Lee, A.5    Chun, C.6    Cheng, S.-Y.7    Korc, M.8
  • 12
    • 19044367102 scopus 로고    scopus 로고
    • Specific targeting of tumor vasculature by diphtheria toxin-vascular endothelial growth factor fusion protein reduces angiogenesis and growth of pancreatic cancer
    • Hotz H, Gill P, Masood R, Hotz B, Buhr H, Foitzik T, Hines OJ, Reber H. Specific targeting of tumor vasculature by diphtheria toxin-vascular endothelial growth factor fusion protein reduces angiogenesis and growth of pancreatic cancer. J Gastrointest Surg. 2002; 6:159-166.
    • (2002) J Gastrointest Surg , vol.6 , pp. 159-166
    • Hotz, H.1    Gill, P.2    Masood, R.3    Hotz, B.4    Buhr, H.5    Foitzik, T.6    Hines, O.J.7    Reber, H.8
  • 14
    • 0036021883 scopus 로고    scopus 로고
    • Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor
    • Ogawa T, Takayama K, Takakura N, Kitano S, Ueno H. Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor. Cancer Gene Ther. 2002; 9:633-640.
    • (2002) Cancer Gene Ther , vol.9 , pp. 633-640
    • Ogawa, T.1    Takayama, K.2    Takakura, N.3    Kitano, S.4    Ueno, H.5
  • 15
    • 0035217589 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, and inhibitor of the vascular endothelial growth factor receptor tyrosine kinases
    • Solorzano CC, Baker CH, Bruns CJ, Killion JJ, Ellis LM, Wood J, Fidler IJ. Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, and inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Cancer Biotherapy and Radiopharmaceuticals. 2001; 16:359-370.
    • (2001) Cancer Biotherapy and Radiopharmaceuticals , vol.16 , pp. 359-370
    • Solorzano, C.C.1    Baker, C.H.2    Bruns, C.J.3    Killion, J.J.4    Ellis, L.M.5    Wood, J.6    Fidler, I.J.7
  • 21
    • 84902482580 scopus 로고    scopus 로고
    • Pancreatic cancer stroma: friend or foe?
    • Gore J, Korc M. Pancreatic cancer stroma: friend or foe? Cancer Cell. 2014; 25:711-712.
    • (2014) Cancer Cell , vol.25 , pp. 711-712
    • Gore, J.1    Korc, M.2
  • 23
    • 84879952361 scopus 로고    scopus 로고
    • Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer
    • Oxford, England :1990
    • Rougier P, Riess H, Manges R, Karasek P, Humblet Y, Barone C, Santoro A, Assadourian S, Hatteville L, Philip PA. Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer. European journal of cancer. Oxford, England: 19902013; 49:2633-2642.
    • (2013) European journal of cancer , vol.49 , pp. 2633-2642
    • Rougier, P.1    Riess, H.2    Manges, R.3    Karasek, P.4    Humblet, Y.5    Barone, C.6    Santoro, A.7    Assadourian, S.8    Hatteville, L.9    Philip, P.A.10
  • 25
    • 2542471865 scopus 로고    scopus 로고
    • Pathways for aberrant angiogenesis in pancreatic cancer
    • Korc M. Pathways for aberrant angiogenesis in pancreatic cancer. Molecular Cancer. 2003; 2:8.
    • (2003) Molecular Cancer , vol.2 , pp. 8
    • Korc, M.1
  • 27
    • 80052127297 scopus 로고    scopus 로고
    • Deletion of Rb Accelerates Pancreatic Carcinogenesis by Oncogenic Kras and Impairs Senescence in Premalignant Lesions
    • Carrière C, Gore AJ, Norris AM, Gunn JR, Young AL, Longnecker DS, Korc M. Deletion of Rb Accelerates Pancreatic Carcinogenesis by Oncogenic Kras and Impairs Senescence in Premalignant Lesions. Gastroenterology. 2011; 141:1091-1101.
    • (2011) Gastroenterology , vol.141 , pp. 1091-1101
    • Carrière, C.1    Gore, A.J.2    Norris, A.M.3    Gunn, J.R.4    Young, A.L.5    Longnecker, D.S.6    Korc, M.7
  • 30
    • 0027131252 scopus 로고
    • Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival
    • Friess H, Yamanaka Y, Buchler M, Ebert M, Beger HG, Gold LI, Korc M. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology. 1993; 105:1846-1856.
    • (1993) Gastroenterology , vol.105 , pp. 1846-1856
    • Friess, H.1    Yamanaka, Y.2    Buchler, M.3    Ebert, M.4    Beger, H.G.5    Gold, L.I.6    Korc, M.7
  • 35
    • 0025181577 scopus 로고
    • A mouse lymphoid endothelial cell line immortalized by simian virus 40 binds lymphocytes and retains functional characteristics of normal endothelial cells
    • O'Connell KA, Edidin M. A mouse lymphoid endothelial cell line immortalized by simian virus 40 binds lymphocytes and retains functional characteristics of normal endothelial cells. The Journal of Immunology. 1990; 144:521-525.
    • (1990) The Journal of Immunology , vol.144 , pp. 521-525
    • O'Connell, K.A.1    Edidin, M.2
  • 36
    • 47949128950 scopus 로고    scopus 로고
    • Angiogenesis: TGF[beta] makes a new friend
    • Danovi SA. Angiogenesis: TGF[beta] makes a new friend. Nat Rev Cancer. 2008; 8:572-572.
    • (2008) Nat Rev Cancer , vol.8 , pp. 572-572
    • Danovi, S.A.1
  • 37
    • 0034803035 scopus 로고    scopus 로고
    • Soluble Type II Transforming Growth Factor-β (TGF-β) Receptor Inhibits TGF-β Signaling in COLO-35 Pancreatic Cancer Cells in Vitro and Attenuates Tumor Formation
    • Rowland-Goldsmith MA, Maruyama H, Kusama T, Ralli S, Korc M. Soluble Type II Transforming Growth Factor-β (TGF-β) Receptor Inhibits TGF-β Signaling in COLO-35 Pancreatic Cancer Cells in Vitro and Attenuates Tumor Formation. Clinical Cancer Research. 2001; 7:2931-2940.
    • (2001) Clinical Cancer Research , vol.7 , pp. 2931-2940
    • Rowland-Goldsmith, M.A.1    Maruyama, H.2    Kusama, T.3    Ralli, S.4    Korc, M.5
  • 39
    • 79956364928 scopus 로고    scopus 로고
    • CCN1: a novel target for pancreatic cancer
    • Leask A. CCN1: a novel target for pancreatic cancer. J Cell Commun Signal. 2011; 5:123-124.
    • (2011) J Cell Commun Signal , vol.5 , pp. 123-124
    • Leask, A.1
  • 40
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg J, Darnell JE Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene. 2000; 19:2468-2473.
    • (2000) Oncogene , vol.19 , pp. 2468-2473
    • Bromberg, J.1    Darnell, J.E.2
  • 41
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer-new molecular targets come of age
    • Yu H, Jove R. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer. 2004; 4:97-105.
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 43
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol. 2007; 7:41-51.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 45
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of Cancer: The Next Generation
    • Hanahan D, Weinberg Robert A. Hallmarks of Cancer: The Next Generation. Cell. 2011; 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg Robert, A.2
  • 47
    • 84902147062 scopus 로고    scopus 로고
    • Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
    • Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States. Cancer Research. 2014; 74:2913-2921.
    • (2014) Cancer Research , vol.74 , pp. 2913-2921
    • Rahib, L.1    Smith, B.D.2    Aizenberg, R.3    Rosenzweig, A.B.4    Fleshman, J.M.5    Matrisian, L.M.6
  • 49
    • 84861373535 scopus 로고    scopus 로고
    • A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis
    • Whipple CA, Young AL, Korc M. A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis. Oncogene. 2012; 31:2535-2544.
    • (2012) Oncogene , vol.31 , pp. 2535-2544
    • Whipple, C.A.1    Young, A.L.2    Korc, M.3
  • 50
    • 77950279550 scopus 로고    scopus 로고
    • Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models
    • Fukumura DAI, Duda DG, Munn LL, Jain RK. Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models. Microcirculation. 2010; 17:206-225.
    • (2010) Microcirculation , vol.17 , pp. 206-225
    • Fukumura, D.A.I.1    Duda, D.G.2    Munn, L.L.3    Jain, R.K.4
  • 51
    • 84901473312 scopus 로고    scopus 로고
    • Imaging hallmarks of cancer in living mice
    • Ellenbroek SIJ, van Rheenen J. Imaging hallmarks of cancer in living mice. Nat Rev Cancer. 2014; 14:406-418.
    • (2014) Nat Rev Cancer , vol.14 , pp. 406-418
    • Ellenbroek, S.I.J.1    van Rheenen, J.2
  • 53
    • 39549102220 scopus 로고    scopus 로고
    • STAT3: A critical transcription activator in angiogenesis
    • Chen Z, Han ZC. STAT3: A critical transcription activator in angiogenesis. Medicinal Research Reviews. 2008; 28:185-200.
    • (2008) Medicinal Research Reviews , vol.28 , pp. 185-200
    • Chen, Z.1    Han, Z.C.2
  • 54
    • 84908161000 scopus 로고    scopus 로고
    • Revisiting STAT3 signalling in cancer: new and unexpected biological functions
    • Yu H, Lee H, Herrmann A, Buettner R, Jove R. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer. 2014; 14:736-746.
    • (2014) Nat Rev Cancer , vol.14 , pp. 736-746
    • Yu, H.1    Lee, H.2    Herrmann, A.3    Buettner, R.4    Jove, R.5
  • 59
  • 65
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: a leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009; 9:798-809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 68
    • 0016793022 scopus 로고
    • Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas
    • Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. International Journal of Cancer. 1975; 15:741-747.
    • (1975) International Journal of Cancer , vol.15 , pp. 741-747
    • Lieber, M.1    Mazzetta, J.2    Nelson-Rees, W.3    Kaplan, M.4    Todaro, G.5
  • 72
    • 79961123152 scopus 로고    scopus 로고
    • RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
    • Li B, Dewey C. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics. 2011; 12:323.
    • (2011) BMC Bioinformatics , vol.12 , pp. 323
    • Li, B.1    Dewey, C.2
  • 73
    • 59449095125 scopus 로고    scopus 로고
    • 14-3-3s Modulates Pancreatic Cancer Cell Survival and Invasiveness
    • Neupane D, Korc M. 14-3-3s Modulates Pancreatic Cancer Cell Survival and Invasiveness. Clin Can Res. 2008; 14:7614-7623.
    • (2008) Clin Can Res , vol.14 , pp. 7614-7623
    • Neupane, D.1    Korc, M.2
  • 74
    • 84896921230 scopus 로고    scopus 로고
    • DUSP1 Is a Novel Target for Enhancing Pancreatic Cancer Cell Sensitivity to Gemcitabine
    • Liu F, Gore AJ, Wilson JL, Korc M. DUSP1 Is a Novel Target for Enhancing Pancreatic Cancer Cell Sensitivity to Gemcitabine. PLoS ONE. 2014; 9:e84982.
    • (2014) PLoS ONE , vol.9
    • Liu, F.1    Gore, A.J.2    Wilson, J.L.3    Korc, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.