Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of pseudoalteromonas SANK73390

Angewandte Chemie - International Edition

Volumn 50, Issue 14, 2011, Pages 3271-3274

  Murphy, Annabel C ^a   Fukuda, Daisuke ^b   Song, Zhongshu ^a   Hothersall, Joanne ^b   Cox, Russell J ^a   Willis, Christine L ^a   Thomas, Christopher M ^b   Simpson, Thomas J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

antibiotics; biosynthesis; methicillin resistance; mupirocin; thiomarinol

Indexed keywords

MARINE BACTERIUM; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MUPIROCIN; MUTAGENESIS EXPERIMENT; MUTANT STRAIN; MUTASYNTHESIS; POTENT ACTIVITY; PSEUDOALTEROMONAS; THIOMARINOL; WILD TYPES;

BACTERIA; BIOCHEMISTRY; BIOMATERIALS; BIOSYNTHESIS; CARBOXYLIC ACIDS; MARINE ENGINEERING; MUTAGENESIS;

ANTIBIOTICS;

ANTIINFECTIVE AGENT; DRUG DERIVATIVE; PSEUDOMONIC ACID; THIOMARINOL;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GENETICS; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGICAL EXAMINATION; PSEUDOALTEROMONAS;

ANTI-BACTERIAL AGENTS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MUPIROCIN; PSEUDOALTEROMONAS;

EID: 79952999917     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201007029     Document Type: Article

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