Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice

American Journal of Chinese Medicine

Volumn 43, Issue 2, 2015, Pages 231-240

  Chen, Mo Si ^a   Zhang, Jia Hua ^a   Wang, Jia Ling ^a,b   Gao, Lu ^a   Chen, Xiao Xu ^a   Xiao, Jun Hua ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province   (China)

Author keywords

Carbon Tetrachloride; Colchicine; Hepatic Fibrosis; Neferine; TGF 1

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COLCHICINE; HYDROXYPROLINE; NEFERINE; OLIVE OIL; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA1; BENZYLISOQUINOLINE DERIVATIVE; CARBON TETRACHLORIDE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CARBON TETRACHLORIDE-INDUCED LIVER FIBROSIS; CONTROLLED STUDY; HEPATOMEGALY; HISTOLOGY; MALE; MOUSE; NELUMBO NUCIFERA; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; INBRED MOUSE STRAIN; INTRAPERITONEAL DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; LIVER; LIVER CIRRHOSIS; METABOLISM; NELUMBO; PHYTOTHERAPY;

ANIMALS; BENZYLISOQUINOLINES; CARBON TETRACHLORIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAPERITONEAL; LIVER; LIVER CIRRHOSIS; MALE; MICE, INBRED STRAINS; NELUMBO; PHYTOTHERAPY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84928383923     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X15500159     Document Type: Article

References (17)

1. Chen, H., Y. Zhou, K. Chen, G. An, S. Ji and Q. Chen. Anti-fibrotic effects via regulation of transcription factor Sp1 on hepatic stellate cells. Cell. Physiol. Biochem. 29: 51-60, 2012.
2. Constandinou, C., N. Henderson and J. Iredale. Modeling liver fibrosis in rodents. Methods. Mol. Med. 117: 237-250, 2005.
3. Ding, H., J. Shi, Y. Wang, J. Guo, J. Zhao and L. Dong. Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: A possible molecular mechanism. Eur. J. Pharmacol. 650: 163-169, 2011.
4. Dooley, S., J. Hamzavi, K. Breitkopf, E. Wiercinska, H. Said, J. Lorenzen, D. Ten and A. Gressner. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology 125: 178-191, 2003.
5. Dooley, S. and D. Ten. TGF-beta in progression of liver disease. Cell Tissue Res. 347: 245-256, 2012.
6. Iwakiri, Y., V. Shah and D. Rockey. Vascular pathobiology in chronic liver disease and cirrhosis - Current status and future directions. J. Hepatol. 61: 912-924, 2014.
7. Kamato, D., M. Burch, T. Piva, H. Rezaei, M. Rostam, S. Xu, W. Zheng, P. Little and N. Osman. Transforming growth factor-beta signaling: Role and consequences of Smad linker region phosphorylation. Cell Signal. 25: 2017-2024, 2013.
8. Lee, S., Y. Kim, K. Kang, C. Kim and S. Kim. Effects of colchicine on liver functions of cirrhotic rats: Beneficial effects result from stellate cell inactivation and inhibition of TGF beta1 expression. Chem. Biol. Interact. 147: 9-21, 2004.
9. Lee, W., K. Kim, H. An, J. Kim, S. Lee, S. Han, S. Pak and K. Park. Apamin inhibits hepatic fibrosis through suppression of transforming growth factor beta1-induced hepatocyte epithelial-mesenchymal transition. Biochem. Biophys. Res. Commun. 450: 195-201, 2014.
10. Matsuzaki, K. Smad phosphoisoform signals in acute and chronic liver injury: Similarities and differences between epithelial and mesenchymal cells. Cell Tissue Res. 347: 225-243, 2012.
11. Niu, C., Y. Wang, J. Liu, J. Wang and J. Xiao. Protective effects of neferine on amiodarone-induced pulmonary fibrosis in mice. Eur. J. Pharmacol. 714: 112-119, 2013.
12. Peng, J., X. Li, Q. Feng, L. Chen, L. Xu and Y. Hu. Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-beta1/Smad signalling, MMPs and TIMPs. Exp. Biol. Med. (Maywood) 238: 668-677, 2013.
13. Shi, Y. and J. Massague. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700, 2003.
14. Uemura, M., E. Swenson, M. Gaca, F. Giordano, M. Reiss and R. Wells. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol. Biol. Cell 16: 4214-4224, 2005.
15. Yoshida, K. and K. Matsuzaki. Differential regulation of TGF-beta/Smad signaling in hepatic stellate cells between acute and chronic liver injuries. Front. Physiol. 3: 53, 2012.
16. Zhao, L., X. Wang, Q. Chang, J. Xu, Y. Huang, Q. Guo, S. Zhang, W. Wang, X. Chen and J. Wang. Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis. Eur. J. Pharmacol. 627: 304-312, 2010.
17. Zhou, J., D. Zhong, Q. Wang, X. Miao and X. Xu. Paclitaxel ameliorates fibrosis in hepatic stellate cells via inhibition of TGF-beta/Smad activity. World J. Gastroenterol. 16: 3330-3334, 2010.