Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-β1/Smad signalling, MMPs and TIMPs

Experimental Biology and Medicine

Volumn 238, Issue 6, 2013, Pages 668-677

  Peng, Jinghua ^a,b,c   Li, Xuemei ^d   Feng, Qin ^a,b,c   Chen, Liang ^a,b,c   Xu, Lili ^a,b,c   Hu, Yiyang ^a,b,c,e  

^a SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai Key Laboratory of Traditional Chinese Clinical Medicine   (China)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^e Shanghai Municipal Education Commission   (China)

Author keywords

Cordyceps sinensis polysaccharide; hepatic stellate cell (HSC); liver fibrosis; matrix metalloproteinase (MMP); tissue inhibitor of metalloproteinase (TIMP); transforming growth factor 1 (TGF 1)

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; COLCHICINE; COLLAGEN; FUNGAL POLYSACCHARIDE; GELATINASE A; GELATINASE B; HYDROXYPROLINE; SMAD2 PROTEIN; SMAD3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL ACTIVATION; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; MALE; MASS FRAGMENTOGRAPHY; NONHUMAN; OPHIOCORDYCEPS; ORGAN WEIGHT; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL; ULTRAVIOLET SPECTROPHOTOMETRY; WESTERN BLOTTING; ZYMOGRAPHY;

CORDYCEPS SINENSIS POLYSACCHARIDE; HEPATIC STELLATE CELL (HSC); LIVER FIBROSIS; MATRIX METALLOPROTEINASE (MMP); TISSUE INHIBITOR OF METALLOPROTEINASE (TIMP); TRANSFORMING GROWTH FACTOR-Β1 (TGF-Β1);

ANIMALS; CARBON TETRACHLORIDE; CORDYCEPS; DOWN-REGULATION; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS; MALE; MATRIX METALLOPROTEINASES; MEDICINE, CHINESE TRADITIONAL; PROTEASE INHIBITORS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84883788965     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370213480741     Document Type: Article

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