Neferine inhibits cultured hepatic stellate cell activation and facilitates apoptosis: A possible molecular mechanism

European Journal of Pharmacology

Volumn 650, Issue 1, 2011, Pages 163-169

  Ding, Hui ^a,b   Shi, Jinghong ^b   Wang, Ying ^a   Guo, Jia ^a   Zhao, Juhui ^a   Dong, Lei ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b SHAANXI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Hepatic fibrosis; Hepatic stellate cell; Neferine

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CASPASE 3; COLLAGEN TYPE 1; FAS LIGAND; MESSENGER RNA; NEFERINE; PROTEIN BAX; PROTEIN BCL 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOASSAY; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; INCUBATION TIME; INHIBITION KINETICS; LIVER FIBROSIS; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; APOPTOSIS; BENZYLISOQUINOLINES; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; COLLAGEN TYPE I; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS; RATS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1;

EID: 78649729128     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.025     Document Type: Article

References (30)

1. R.T. Allen, W.J. Hunter, and D.K. Agrawal Morphological and biochemical characterization and analysis of apoptosis Pharmacol. Toxicol. Meth. 37 1997 215 228
2. A. Anan, E.S. Baskin-Bey, S.F. Bronk, N.W. Werneburg, V.H. Shah, and G.J. Gores Proteasome inhibition induces hepatic stellate cell apoptosis Hepatology 43 2006 335 344
3. R. Bataller, and D.A. Brenner Hepatic stellate cells as a target for the treatment of liver fibrosis Semin. Liver Dis. 21 2001 437 451
4. K. Breitkopf, S. Haas, E. Wiercinska, M.V. Singer, and S. Dooley Anti-TGF-beta strategies for the treatment of chronic liver disease Alcohol. Clin. Exp. Res. 29 11 Suppl. 2005 121S 131S
5. A.D. Burt Cellular and molecular aspects of hepatic fibrosis J. Pathol. 170 1993 105 114
6. V. Carloni, R.G. Romanelli, M. Pinzani, G. Laffi, and P. Gentilini Focal adhesion kinase and phyospholipase C gamma involvement in adhesion and migration of human hepatic stellate cells Gastroenterology 112 1997 522 531
7. S. Dooley, J. Hamzavi, K. Breitkopf, E. Wiercinska, H.M. Said, J. Lorenzen, P.T. Dijke, and A.M. Gressner Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats Gastroenterology 125 2003 178 191
8. P.J. Duriez, and G.M. Shah Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death Biochem. Cell Biol. 75 1997 337 349
9. S.L. Friedman Liver fibrosis-from bench to bedside J. Hepatol. 38 Suppl 1 2003 S38 S53
10. S.L. Friedman Stellate cells: a moving target in hepatic fibrogenesis Hepatology 40 2004 1041 1043
11. D.R. Green, and J.C. Reed Mitochondria and apoptosis Science 281 1998 1309 1312
12. A.M. Gressner, and R. Weiskirchen Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets J. Cell. Mol. Med. 10 2006 76 99
13. C.J. Huang, and M.C. Wu Differential effects of foods traditionally regarded as 'heating' and 'cooling' on prostaglandin E2 production by a macrophage cell line J. Biomed. Sci. 9 2002 596 606
14. K. Ikejima, H. Honda, M. Yoshikawa, M. Hirose, T. Kitamura, Y. Takei, and N. Sato Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals Hepatology 34 2001 288 297
15. J.P. Iredale, R.C. Benyon, J. Pickering, M. McCullen, M. Northrop, S. Pawley, C. Hovell, and M.J. Arthur Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors J. Clin. Invest. 102 1998 538 549
16. H.C. Kang, J.X. Nan, P.H. Park, J.Y. Kim, S.H. Lee, S.W. Woo, Y.Z. Zhao, E.J. Park, and D.H. Sohn Curcumin inhibits collagen synthesis and hepatic stellate cell activation in-vivo and in-vitro J. Pharm. Pharmacol. 54 2002 119 126
17. 9/core promoter-binding protein and Sp1: potential mechanisms for autocrine fibrogenesis in response to injury J. Biol. Chem. 273 1998 33750 33758
18. 2+ in guinea pig atria Acta Pharm. Sin. 23 1988 241 245
19. C.P. Liu, W.J. Tsai, Y.L. Lin, J.F. Liao, C.F. Chen, and Y.C. Kuo The extracts from Nelumbo Nucifera suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells Life Sci. 75 2004 699 716
20. P.K. Mukherjee, K. Saha, R. Balasubramanian, M. Pal, and B.P. Saha Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract J. Ethnopharmacol. 54 1996 63 67
21. S. Nagata, and P. Golstein The Fas death factor Science 267 1995 1449 1456
22. 4-induced hepatic injuries in rats: a histochemical, immunohistochemical and ultrastructural study Acta Histochem. 107 2006 421 434
23. T. Ogawa, M. Iizuka, Y. Sekiya, K. Yoshizato, K. Ikeda, and N. Kawada Suppression of type I collagen production by microRNA-29b in cultured human stellate cells Biochem. Biophys. Res. Commun. 391 2010 316 321
24. E. Ohkoshi, H. Miyazaki, K. Shindo, H. Watanabe, A. Yoshida, and H. Yajima Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice Planta Med. 73 2007 1255 1259
25. J.C. Reed, and K.J. Tomaselli Drug discovery opportunities from apoptosis research Curr. Opin. Biotechnol. 11 2000 586 592
26. F.W. Shek, and R.C. Benyon How can transforming growth factor beta be targeted usefully to combat liver fibrosis? Eur. J. Gastroenterol. Hepatol. 16 2004 123 126
27. T. Suda, T. Takahashi, P. Golstein, and S. Nagata Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family Cell 75 1993 1169 1178
28. H. Ueno, T. Sakamoto, T. Nakamura, Z. Qi, N. Astuchi, A. Takeshita, K. Shimizu, and H. Ohashi A soluble transforming growth factor beta receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats Hum. Gene Ther. 11 2000 33 42
29. M.C. Wright, R. Issa, D.E. Smart, N. Trim, G.I. Murray, J.N. Primrose, M.J. Arthur, J.P. Iredale, and D.A. Mann Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats Gastroenterology 121 2001 685 698
30. L.B. Zhao, X.M. Wang, Q. Chang, J.Y. Xu, Y. Huang, Q.Y. Guo, S.H. Zhang, W.Q. Wang, X.J. Chen, and J.L. Wang Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis Eur. J. Pharmacol. 627 2010 304 312