메뉴 건너뛰기




Volumn 17, Issue 5, 2015, Pages

Next Generation of Weight Management Medications: Implications for Diabetes and CVD Risk

Author keywords

Cardiometabolic risks; Medications; Weight management

Indexed keywords

AMFEBUTAMONE PLUS NALTREXONE; AMFEBUTAMONE PLUS ZONISAMIDE; ANTIOBESITY AGENT; CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INSULIN; LIRAGLUTIDE; LORCASERIN; LOW DENSITY LIPOPROTEIN; METRELEPTIN PLUS PRAMLINTIDE; PHENTERMINE PLUS TOPIRAMATE; PLACEBO; TESOFENSINE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84928347829     PISSN: 15233782     EISSN: 15343170     Source Type: Journal    
DOI: 10.1007/s11886-015-0590-z     Document Type: Review
Times cited : (15)

References (65)
  • 1
    • 84928322159 scopus 로고    scopus 로고
    • WHO. Obes. Overweight fact sheet. 2013. Accessed 16 Oct 2014
    • WHO. Obes. Overweight fact sheet. 2013. Available at: http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed 16 Oct 2014.
  • 2
    • 84878696356 scopus 로고    scopus 로고
    • Cardiovascular disease in childhood: the role of obesity
    • Herouvi D, Karanasios E, Karayianni C, et al. Cardiovascular disease in childhood: the role of obesity. Eur J Pediatr. 2013;172:721–32.
    • (2013) Eur J Pediatr , vol.172 , pp. 721-732
    • Herouvi, D.1    Karanasios, E.2    Karayianni, C.3
  • 3
    • 84880922995 scopus 로고    scopus 로고
    • New pharmacological approaches for obesity management
    • COI: 1:CAS:528:DC%2BC3sXhtFGmsrzM
    • Rueda-Clausen CF, Padwal RS, Sharma AM. New pharmacological approaches for obesity management. Nat Rev Endocrinol. 2013;9:467–78.
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 467-478
    • Rueda-Clausen, C.F.1    Padwal, R.S.2    Sharma, A.M.3
  • 4
    • 84867903044 scopus 로고    scopus 로고
    • Recent advancements in drug treatment of obesity
    • Carter R, Mouralidarane A, Ray S, et al. Recent advancements in drug treatment of obesity. Clin Med. 2012;12:456–60.
    • (2012) Clin Med , vol.12 , pp. 456-460
    • Carter, R.1    Mouralidarane, A.2    Ray, S.3
  • 5
    • 29944438889 scopus 로고    scopus 로고
    • Pharmacotherapy for obesity
    • COI: 1:CAS:528:DC%2BD28XitFCrsg%3D%3D
    • Halford JCG. Pharmacotherapy for obesity. Appetite. 2006;46:6–10.
    • (2006) Appetite , vol.46 , pp. 6-10
    • Halford, J.C.G.1
  • 6
    • 84898987526 scopus 로고    scopus 로고
    • Pharmacotherapy for obesity: novel agents and paradigms
    • COI: 1:CAS:528:DC%2BC2cXhs1OntbvP
    • Manning S, Pucci A, Finer N. Pharmacotherapy for obesity: novel agents and paradigms. Ther Adv Chronic Dis. 2014;5:135–48.
    • (2014) Ther Adv Chronic Dis , vol.5 , pp. 135-148
    • Manning, S.1    Pucci, A.2    Finer, N.3
  • 7
    • 84876483004 scopus 로고    scopus 로고
    • Efficacy and safety of lorcaserin in obese adults: a meta-analysis of 1-year randomized controlled trials (RCTs) and narrative review on short-term RCTs
    • COI: 1:CAS:528:DC%2BC3sXmt1Ohu7s%3D
    • Chan EW, He Y, Chui CSL, et al. Efficacy and safety of lorcaserin in obese adults: a meta-analysis of 1-year randomized controlled trials (RCTs) and narrative review on short-term RCTs. Obes Rev. 2013;14:383–92.
    • (2013) Obes Rev , vol.14 , pp. 383-392
    • Chan, E.W.1    He, Y.2    Chui, C.S.L.3
  • 8
    • 84928349593 scopus 로고    scopus 로고
    • Orexigen Therapeutics Inc. Orexigen press release 2013—Contrave and Empatic. 2013. 1–5. Accessed 27 Oct 2014
    • Orexigen Therapeutics Inc. Orexigen press release 2013—Contrave and Empatic. 2013. 1–5. Available at: http://ir.orexigen.com/phoenix.zhtml?c=207034&p=irol-newsArticle&ID=1817249. Accessed 27 Oct 2014.
  • 9
    • 84928346207 scopus 로고    scopus 로고
    • FDA. Contrave (naltrexone sr/bupropion SR combination): Advisory Committee Briefing Document. 2010;1–278
    • FDA. Contrave (naltrexone sr/bupropion SR combination): Advisory Committee Briefing Document. 2010;1–278.
  • 10
    • 77957754436 scopus 로고    scopus 로고
    • New approaches to the pharmacological treatment of obesity: can they break through the efficacy barrier?
    • COI: 1:CAS:528:DC%2BC3cXht1Oms73L
    • Kennett GA, Clifton PG. New approaches to the pharmacological treatment of obesity: can they break through the efficacy barrier? Pharmacol Biochem Behav. 2010;97:63–83.
    • (2010) Pharmacol Biochem Behav , vol.97 , pp. 63-83
    • Kennett, G.A.1    Clifton, P.G.2
  • 12
    • 84928338985 scopus 로고    scopus 로고
    • FDA. Ephedrine alkaloid-containing dietary supplements. 2003. Accessed 2 Oct 2014
    • FDA. Ephedrine alkaloid-containing dietary supplements. 2003. Available at: http://www.fda.gov/newsevents/testimony/ucm115044.htm. Accessed 2 Oct 2014.
  • 13
    • 20744433854 scopus 로고    scopus 로고
    • Cardiovascular effects of ephedra alkaloids: a comprehensive review
    • COI: 1:CAS:528:DC%2BD2MXos1ams7k%3D
    • Andraws R, Chawla P, Brown DL. Cardiovascular effects of ephedra alkaloids: a comprehensive review. Prog Cardiovasc Dis. 2005;47:217–25.
    • (2005) Prog Cardiovasc Dis , vol.47 , pp. 217-225
    • Andraws, R.1    Chawla, P.2    Brown, D.L.3
  • 14
    • 84928342927 scopus 로고    scopus 로고
    • EMA. Press release: the European Medicines Agency recommends suspension of the marketing authorisation of Acomplia. 2008;4–5
    • EMA. Press release: the European Medicines Agency recommends suspension of the marketing authorisation of Acomplia. 2008;4–5.
  • 15
    • 33845874637 scopus 로고    scopus 로고
    • Drug treatments for obesity: orlistat, sibutramine, and rimonabant
    • COI: 1:CAS:528:DC%2BD2sXit12itQ%3D%3D
    • Padwal RS, Majumdar SR. Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet. 2007;369:71–7.
    • (2007) Lancet , vol.369 , pp. 71-77
    • Padwal, R.S.1    Majumdar, S.R.2
  • 16
    • 0030876952 scopus 로고    scopus 로고
    • Vaulvular heart disease associated with fenfluramine-phentermine
    • COI: 1:CAS:528:DyaK2sXmtVGntLc%3D
    • Connolly H, Crary J, McGoon M, et al. Vaulvular heart disease associated with fenfluramine-phentermine. N Engl J Med. 1997;337:581–8.
    • (1997) N Engl J Med , vol.337 , pp. 581-588
    • Connolly, H.1    Crary, J.2    McGoon, M.3
  • 17
    • 84894874002 scopus 로고    scopus 로고
    • Management of obesity and cardiometabolic risk—role of phentermine / extended release topiramate
    • Sweeting AN, Tabet E, Caterson ID, et al. Management of obesity and cardiometabolic risk—role of phentermine / extended release topiramate. Diabetes Metab Syndr Obes. 2014;12:35–44.
    • (2014) Diabetes Metab Syndr Obes , vol.12 , pp. 35-44
    • Sweeting, A.N.1    Tabet, E.2    Caterson, I.D.3
  • 20
    • 84891919414 scopus 로고    scopus 로고
    • Long-term drug treatment for obesity: a systematic and clinical review
    • COI: 1:CAS:528:DC%2BC2cXitF2nurY%3D
    • Yanovski S, Yanovski JA. Long-term drug treatment for obesity: a systematic and clinical review. JAMA. 2014;311:74–86.
    • (2014) JAMA , vol.311 , pp. 74-86
    • Yanovski, S.1    Yanovski, J.A.2
  • 21
    • 84906318432 scopus 로고    scopus 로고
    • Benefit-risk assessment of orlistat in the treatment of obesity
    • COI: 1:CAS:528:DC%2BC2cXht1Gks7bE
    • Sumithran P, Proietto J. Benefit-risk assessment of orlistat in the treatment of obesity. Drug Saf. 2014;37:597–608.
    • (2014) Drug Saf , vol.37 , pp. 597-608
    • Sumithran, P.1    Proietto, J.2
  • 22
    • 1042303480 scopus 로고    scopus 로고
    • XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients
    • COI: 1:CAS:528:DC%2BD2cXmvV2jug%3D%3D
    • Torgerson J, Hauptman J, Boldrin M, et al. XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients. Diabetes Care. 2004;27:155–61.
    • (2004) Diabetes Care , vol.27 , pp. 155-161
    • Torgerson, J.1    Hauptman, J.2    Boldrin, M.3
  • 23
    • 2942519185 scopus 로고    scopus 로고
    • Cholesterol lowering effect of dietary weight loss and orlistat treatment—efficacy and limitations
    • COI: 1:CAS:528:DC%2BD2cXlsFyiurg%3D
    • Erdmann J, Lippl F, Klose G, et al. Cholesterol lowering effect of dietary weight loss and orlistat treatment—efficacy and limitations. Aliment Pharmacol Ther. 2004;19:1173–9.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 1173-1179
    • Erdmann, J.1    Lippl, F.2    Klose, G.3
  • 24
    • 84876056876 scopus 로고    scopus 로고
    • Reducing the risk of developing diabetes
    • Ransom T, Goldenberg R, Mikalachki A, et al. Reducing the risk of developing diabetes. Can J diabetes. 2013;37 Suppl 1:S16–9.
    • (2013) Can J diabetes , vol.37 , pp. 16-19
    • Ransom, T.1    Goldenberg, R.2    Mikalachki, A.3
  • 25
    • 84903133961 scopus 로고    scopus 로고
    • 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society
    • Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation. 2014;129:S102–38.
    • (2014) Circulation , vol.129 , pp. 102-138
    • Jensen, M.D.1    Ryan, D.H.2    Apovian, C.M.3
  • 26
    • 84922570654 scopus 로고    scopus 로고
    • Pharmacological management of obesity: an endocrine society clinical practice guideline
    • Apovian CM, Aronne LJ, Bessesen DH, et al. Pharmacological management of obesity: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2015.
    • (2015) J Clin Endocrinol Metab
    • Apovian, C.M.1    Aronne, L.J.2    Bessesen, D.H.3
  • 27
    • 84856246606 scopus 로고    scopus 로고
    • Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)
    • COI: 1:CAS:528:DC%2BC38XhsFCmsbo%3D
    • Allison DB, Gadde KM, Garvey WT, et al. Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP). Obesity (Silver Spring). 2012;20:330–42.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 330-342
    • Allison, D.B.1    Gadde, K.M.2    Garvey, W.T.3
  • 28
    • 84928335193 scopus 로고    scopus 로고
    • FDA. New Drug Application 22580- VI-0521 QNEXA (phentermine/topiramate). 2012;1–200. This report summarized MACE data and it was determined that there was no significant difference in the risk of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke between phentermine-topiramate and placebo
    • FDA. New Drug Application 22580- VI-0521 QNEXA (phentermine/topiramate). 2012;1–200. This report summarized MACE data and it was determined that there was no significant difference in the risk of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke between phentermine-topiramate and placebo.
  • 29
    • 84898490591 scopus 로고    scopus 로고
    • The new weight-loss drugs, lorcaserin and phentermine-topiramate: slim pickings?
    • Woloshin S, Schwartz L. The new weight-loss drugs, lorcaserin and phentermine-topiramate: slim pickings? JAMA Intern Med. 2014;174:615–9.
    • (2014) JAMA Intern Med , vol.174 , pp. 615-619
    • Woloshin, S.1    Schwartz, L.2
  • 30
    • 79954561234 scopus 로고    scopus 로고
    • Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial
    • COI: 1:CAS:528:DC%2BC3MXkvVSqtL4%3D
    • Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet. 2011;377:1341–52.
    • (2011) Lancet , vol.377 , pp. 1341-1352
    • Gadde, K.M.1    Allison, D.B.2    Ryan, D.H.3
  • 32
    • 84928340642 scopus 로고    scopus 로고
    • VIVUS. VIVUS Updates European Filing Strategy for Qsiva. 2013. 1–2. Accessed 2 Oct 2014
    • VIVUS. VIVUS Updates European Filing Strategy for Qsiva. 2013. 1–2. Available at: http://ir.vivus.com/releasedetail.cfm?ReleaseID=791927. Accessed 2 Oct 2014.
  • 33
    • 84862869642 scopus 로고    scopus 로고
    • Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study
    • O’Neil PM, Smith SR, Weissman NJ, et al. Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study. Obesity. 2012;20:1426–36.
    • (2012) Obesity , vol.20 , pp. 1426-1436
    • O’Neil, P.M.1    Smith, S.R.2    Weissman, N.J.3
  • 34
    • 77954635020 scopus 로고    scopus 로고
    • Multicenter, placebo-controlled trial of lorcaserin for weight management
    • COI: 1:CAS:528:DC%2BC3cXptVOgs74%3D
    • Smith SR, Weissman NJ, Anderson CM, et al. Multicenter, placebo-controlled trial of lorcaserin for weight management. N Engl J Med. 2010;363:245–56.
    • (2010) N Engl J Med , vol.363 , pp. 245-256
    • Smith, S.R.1    Weissman, N.J.2    Anderson, C.M.3
  • 36
    • 80053539943 scopus 로고    scopus 로고
    • A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial
    • COI: 1:CAS:528:DC%2BC3MXhtlyitbnO
    • Fidler MC, Sanchez M, Raether B, et al. A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab. 2011;96:3067–77.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 3067-3077
    • Fidler, M.C.1    Sanchez, M.2    Raether, B.3
  • 37
    • 84928329834 scopus 로고    scopus 로고
    • Eisai. Eisai Begins CAMELLIA-TIMI 61 LT outcomes study to assess cardiometa effects of lorcaserin HCI CIV in OW and OB pts. 2014;1–5. Accessed 28 Nov 2014
    • Eisai. Eisai Begins CAMELLIA-TIMI 61 LT outcomes study to assess cardiometa effects of lorcaserin HCI CIV in OW and OB pts. 2014;1–5. Available at: http://eisai.mediaroom.com/2014-02-24-Eisai-Begins-CAMELLIA-TIMI-61-Long-term-Outcomes-Study-to-Assess-Cardiovascular-and-Metabolic-Effects-of-Lorcaserin-HCI-CIV-in-Overweight-Obese-Patients. Accessed 28 Nov 2014.
  • 38
    • 84928336666 scopus 로고    scopus 로고
    • FDA. FDA approves weight-management drug Contrave. 2014;1–4. Accessed 31 Oct 2014. This webpage provided some of the latest breaking news on Contrave FDA Approval. It also provided useful, publically available, information on study results and medication contraindications
    • FDA. FDA approves weight-management drug Contrave. 2014;1–4. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm413896.htm. Accessed 31 Oct 2014. This webpage provided some of the latest breaking news on Contrave FDA Approval. It also provided useful, publically available, information on study results and medication contraindications.
  • 39
    • 84879324574 scopus 로고    scopus 로고
    • A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II)
    • COI: 1:CAS:528:DC%2BC3sXpvFaksL0%3D
    • Apovian CM, Aronne L, Rubino D, et al. A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity. 2013;21:935–43.
    • (2013) Obesity , vol.21 , pp. 935-943
    • Apovian, C.M.1    Aronne, L.2    Rubino, D.3
  • 40
    • 77956057548 scopus 로고    scopus 로고
    • Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
    • COI: 1:CAS:528:DC%2BC3cXhtVGmtbbK
    • Greenway FL, Fujioka K, Plodkowski RA, et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2010;376:595–605.
    • (2010) Lancet , vol.376 , pp. 595-605
    • Greenway, F.L.1    Fujioka, K.2    Plodkowski, R.A.3
  • 41
    • 84891869792 scopus 로고    scopus 로고
    • Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXhvFaksLvM
    • Hollander P, Gupta A, Plodkowski R, et al. Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes. Diabetes Care. 2013;36:4022–9.
    • (2013) Diabetes Care , vol.36 , pp. 4022-4029
    • Hollander, P.1    Gupta, A.2    Plodkowski, R.3
  • 42
    • 77956904326 scopus 로고    scopus 로고
    • Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial
    • COI: 1:CAS:528:DC%2BC3cXhs1Wkt7zF
    • Wadden TA, Foreyt JP, Foster GD, et al. Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial. Obesity. 2011;19:110–20.
    • (2011) Obesity , vol.19 , pp. 110-120
    • Wadden, T.A.1    Foreyt, J.P.2    Foster, G.D.3
  • 43
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
    • COI: 1:CAS:528:DC%2BD1MXkvVGqur8%3D
    • Marre M, Shaw J, Brändle M, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med. 2009;26:268–78.
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3
  • 44
    • 84928309128 scopus 로고    scopus 로고
    • Novo Nordisk. Phase 3a liraglutide 3 mg trial demonstrated significant weight loss and improved cardiovascular risk factors in adults with obesity and type 2 diabetes compared with placebo. 2014;1–4
    • Novo Nordisk. Phase 3a liraglutide 3 mg trial demonstrated significant weight loss and improved cardiovascular risk factors in adults with obesity and type 2 diabetes compared with placebo. 2014;1–4.
  • 45
    • 84928349793 scopus 로고    scopus 로고
    • FDA. Highlight of prescribing information Victoza. 2010;1–23
    • FDA. Highlight of prescribing information Victoza. 2010;1–23.
  • 46
    • 84928324997 scopus 로고    scopus 로고
    • FDA. Approved diabetes medicines. 2014;1–4. Accessed 29 Oct 2014
    • FDA. Approved diabetes medicines. 2014;1–4. Available at: http://www.fda.gov/forpatients/illness/diabetes/ucm408682.htm#collapse3. Accessed 29 Oct 2014.
  • 47
    • 84928330233 scopus 로고    scopus 로고
    • FDA. FDA approves weight-management drug Saxenda. 2014. Accessed 16 Mar 2015. This report concisely outlined the FDA approval of Saxenda
    • FDA. FDA approves weight-management drug Saxenda. 2014. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427913.htm. Accessed 16 Mar 2015. This report concisely outlined the FDA approval of Saxenda.
  • 48
    • 84928331785 scopus 로고    scopus 로고
    • Novo Nordisk. Novo Nordisk receives Health Canada approval for Saxenda® (liraglutide) for the treatment of chronic weight management. Accessed 13 Mar 2015
    • Novo Nordisk. Novo Nordisk receives Health Canada approval for Saxenda® (liraglutide) for the treatment of chronic weight management. Available at: http://www.newswire.ca/en/story/1494067/novo-nordisk-receives-health-canada-approval-for-saxenda-liraglutide-for-the-treatment-of-chronic-weight-management#. Accessed 13 Mar 2015.
  • 49
    • 84928324914 scopus 로고    scopus 로고
    • Novo Nordisk. Novo Nordisk reports 8 % weight loss in phase 3a obesity trial with liraglutide 3 mg. 2013;24–26
    • Novo Nordisk. Novo Nordisk reports 8 % weight loss in phase 3a obesity trial with liraglutide 3 mg. 2013;24–26.
  • 50
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study
    • COI: 1:CAS:528:DC%2BD1MXhtlyjtLrL
    • Astrup A, Rössner S, Van Gaal L, et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet. 2009;374:1606–16.
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1    Rössner, S.2    Van Gaal, L.3
  • 51
    • 84887840117 scopus 로고    scopus 로고
    • Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study
    • COI: 1:CAS:528:DC%2BC3sXhslynsr3I, This SCALE trial found numerous positive cardiometabolic effects of liraglutide 3.0 mg and is one of the defining studies used to assess the safety of liraglutide for weight management
    • Wadden T, Hollander P, Klein S, et al. Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study. Int J Obes (Lond). 2013;37:1443–51. This SCALE trial found numerous positive cardiometabolic effects of liraglutide 3.0 mg and is one of the defining studies used to assess the safety of liraglutide for weight management.
    • (2013) Int J Obes (Lond) , vol.37 , pp. 1443-1451
    • Wadden, T.1    Hollander, P.2    Klein, S.3
  • 52
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study
    • COI: 1:CAS:528:DC%2BD1MXhs1Ggu7g%3D
    • Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care. 2009;32:84–90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 53
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • COI: 1:CAS:528:DC%2BD1MXhsFKgur0%3D
    • Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet. 2009;373:473–81.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 54
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • COI: 1:CAS:528:DC%2BD1MXps1KqsLs%3D
    • Zinman B, Gerich J, Buse J, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care. 2009;32:1224–30.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.3
  • 55
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial
    • COI: 1:CAS:528:DC%2BD1MXhtVygtLnE
    • Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia. 2009;52:2046–55.
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 56
    • 80052039077 scopus 로고    scopus 로고
    • Cardiovascular safety of liraglutide assessed in a patient-level pooled analysis of phase 2: 3 liraglutide clinical development studies
    • Marso SP, Lindsey JB, Stolker JM, et al. Cardiovascular safety of liraglutide assessed in a patient-level pooled analysis of phase 2: 3 liraglutide clinical development studies. Diab Vasc Dis Res. 2011;8:237–40.
    • (2011) Diab Vasc Dis Res , vol.8 , pp. 237-240
    • Marso, S.P.1    Lindsey, J.B.2    Stolker, J.M.3
  • 57
    • 84890912362 scopus 로고    scopus 로고
    • New and emerging drug molecules against obesity
    • COI: 1:CAS:528:DC%2BC2cXjt1antrk%3D
    • George M, Rajaram M, Shanmugam E. New and emerging drug molecules against obesity. J Cardiovasc Pharmacol Ther. 2014;19:65–76.
    • (2014) J Cardiovasc Pharmacol Ther , vol.19 , pp. 65-76
    • George, M.1    Rajaram, M.2    Shanmugam, E.3
  • 58
    • 56649112848 scopus 로고    scopus 로고
    • Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD1cXhsVelurfO
    • Astrup A, Madsbad S, Breum L, et al. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;372:1906–13.
    • (2008) Lancet , vol.372 , pp. 1906-1913
    • Astrup, A.1    Madsbad, S.2    Breum, L.3
  • 59
    • 84928319607 scopus 로고    scopus 로고
    • Orexigen Therapeutics Inc. Orexigen receives three month extension of FDA NB32. 2014:1–2. Accessed 15 Oct 2014
    • Orexigen Therapeutics Inc. Orexigen receives three month extension of FDA NB32. 2014:1–2. Available at: http://ir.orexigen.com/phoenix.zhtml?c=207034&p=irol-newsArticle&ID=1938944. Accessed 15 Oct 2014.
  • 60
    • 84904313098 scopus 로고    scopus 로고
    • Investigational drugs in phase II clinical trials for the treatment of obesity: implications for future development of novel therapies
    • COI: 1:CAS:528:DC%2BC2cXhtFeltb%2FK
    • Jackson VM, Price DA, Carpino PA. Investigational drugs in phase II clinical trials for the treatment of obesity: implications for future development of novel therapies. Expert Opin Investig Drugs. 2014;23:1055–66.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 1055-1066
    • Jackson, V.M.1    Price, D.A.2    Carpino, P.A.3
  • 62
    • 84928333908 scopus 로고    scopus 로고
    • Orexigen Therapeutics Inc. Emaptic. 2014. Accessed 26 Nov 2014. This web page outlined some of the only available data on the effectiveness of Empatic (bupropion-zonisamide slow-release compound) a promising weight management medication undergoing phase III clinical testing
    • Orexigen Therapeutics Inc. Emaptic. 2014. Available at: http://www.orexigen.com/programs/empatic.html. Accessed 26 Nov 2014. This web page outlined some of the only available data on the effectiveness of Empatic (bupropion-zonisamide slow-release compound) a promising weight management medication undergoing phase III clinical testing.
  • 64
    • 80555135931 scopus 로고    scopus 로고
    • Novel strategy for the use of leptin for obesity therapy
    • COI: 1:CAS:528:DC%2BC3MXhsVags77K
    • Tam CS, Lecoultre V, Ravussin E. Novel strategy for the use of leptin for obesity therapy. Expert Opin Biol Ther. 2011;11:1677–85.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1677-1685
    • Tam, C.S.1    Lecoultre, V.2    Ravussin, E.3
  • 65
    • 84928310557 scopus 로고    scopus 로고
    • PR Newswire, source Amylin Pharmaceuticals Inc. Amylin Pharmaceuticals Announces Positive Results from Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment for Obesity. 2009. Accessed 16 Mar 2014
    • PR Newswire, source Amylin Pharmaceuticals Inc. Amylin Pharmaceuticals Announces Positive Results from Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment for Obesity. 2009. Available at: http://www.prnewswire.com/news-releases/amylin-pharmaceuticals-announces-positive-results-from-dose-ranging-clinical-study-of-pramlintidemetreleptin-combination-treatment-for-obesity-62158697.html. Accessed 16 Mar 2014.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.