Establishing a clinically relevant large animal model platform for TBI therapy development: Using cyclosporin a as a case study

Brain Pathology

Volumn 25, Issue 3, 2015, Pages 289-303

  Margulies, Susan S ^a   Kilbaugh, Todd ^b   Sullivan, Sarah ^a   Smith, Colin ^c   Propert, Kathleen ^a   Byro, Melissa ^a   Saliga, Kristen ^d   Costine, Beth A ^d   Duhaime, Ann Christine ^d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d HARVARD UNIVERSITY   (United States)

Author keywords

Brain injury; Pediatric; Preclinical trials; TBI; Treatment

Indexed keywords

CYCLOSPORIN A; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; CYCLOSPORIN; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AXONAL INJURY; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; FUNCTIONAL ASSESSMENT; MITOCHONDRIAL RESPIRATION; MITOCHONDRION SWELLING; NEUROPROTECTION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PORCINE MODEL; STUDY DESIGN; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN INJURIES; DISEASE MODEL; DRUG EFFECTS; FEMALE; MITOCHONDRION; NEUROLOGIC EXAMINATION; PATHOLOGY; PIG; TIME FACTOR; TRANSLATIONAL RESEARCH; TREATMENT OUTCOME;

ANIMALS; BRAIN INJURIES; CYCLOSPORINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MITOCHONDRIA; NEUROLOGIC EXAMINATION; NEUROPROTECTIVE AGENTS; SWINE; TIME FACTORS; TRANSLATIONAL MEDICAL RESEARCH; TREATMENT OUTCOME;

EID: 84928342892     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12247     Document Type: Conference Paper

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