Pharmacokinetic characterization of a pig model of ciclosporin A nephrotoxicity following intravenous administration

Pharmacological Research

Volumn 56, Issue 4, 2007, Pages 311-317

  Cibulskyte, Donata ^a   Pedersen, Michael ^a   Jakobsen, Preben ^b   Hansen, Hans Erik ^a   Mortensen, Jens ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Anaesthesia; Ciclosporin A; Drug toxicity; Model; Pharmacokinetics; Pig

Indexed keywords

AMPICILLIN; AZAPERONE; CYCLOSPORIN A; ETOMIDATE; ISOFLURANE; KETAMINE; MIDAZOLAM; MIDAZOLAM MALEATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD SAMPLING; CHARACTER STATE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; GLOMERULUS FILTRATION RATE; HALF LIFE TIME; HEMOGLOBIN BLOOD LEVEL; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; NEPHROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SWINE;

ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CREATININE; CYCLOSPORINE; FEMALE; GLOMERULAR FILTRATION RATE; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; KIDNEY; MAGNETIC RESONANCE IMAGING; RANDOM ALLOCATION; RENAL CIRCULATION; SWINE;

EID: 34748827887     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2007.07.010     Document Type: Article

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