Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics

British Journal of Pharmacology

Volumn 172, Issue 10, 2015, Pages 2557-2572

  Seebacher, N A ^a   Richardson, D R ^a   Jansson, P J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; HIF1A PROTEIN, HUMAN; NOX4 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

A549 CELL LINE; ARTICLE; CELL STRESS; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DMS 53 CELL LINE; DRUG TRANSPORT; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; GLUCOSE MODULATION; HUMAN; HUMAN CELL; INCUBATION TIME; KB31 CELL LINE; KBV1 CELL LINE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE DESTABILIZATION; MITOCHONDRIAL MEMBRANE HYPERPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MTT ASSAY; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; TUMOR MICROENVIRONMENT; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL COUNT; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; MITOCHONDRION;

CELL COUNT; CELL LINE, TUMOR; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GLUCOSE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NADPH OXIDASE; NF-KAPPA B; P-GLYCOPROTEIN; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING;

EID: 84928326099     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13079     Document Type: Article

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